DegronMD - Q86YC2(PALB2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A712V	TCGA-06-5416	GBM	TCGA	LLYTPLNT	DEG_SCF_FBW7_1	703:710	Mutation rewiring degron network	0.2778
p.A712V	TCGA-XK-AAIW	PRAD	TCGA	LLYTPLNT	DEG_SCF_FBW7_1	703:710	Mutation rewiring degron network	0.2778
p.A712V	DO10880	GBM	ICGC	LLYTPLNT	DEG_SCF_FBW7_1	703:710	Mutation rewiring degron network	0.2778
p.A712V	DO51407	PRAD	ICGC	LLYTPLNT	DEG_SCF_FBW7_1	703:710	Mutation rewiring degron network	0.2778
p.A712V	SIDM01247	Burkitt's Lymphoma	GDSC	LLYTPLNT	DEG_SCF_FBW7_1	703:710	Mutation rewiring degron network	0.2778
p.E820Q	TCGA-43-A56V	LUSC	TCGA	FKENQ	DEG_APCC_KENBOX_2	818:822	Mutation altering degron motif	0.6744
p.E820Q	DO45535	LUSC	ICGC	FKENQ	DEG_APCC_KENBOX_2	818:822	Mutation altering degron motif	0.6744
p.E384K	TCGA-BA-A4IG	HNSC	TCGA	EKHSCTVPEGL	DEG_COP1_1	392:402	Mutation rewiring degron network	0.1111
p.E384K	DO52028	HNSC	ICGC	EKHSCTVPEGL	DEG_COP1_1	392:402	Mutation rewiring degron network	0.1111
p.P707S	TCGA-DA-A1HY	SKCM	TCGA	LLYTPLNT	DEG_SCF_FBW7_1	703:710	Mutation altering degron motif	0.6752
p.P707S	DO37409	SKCM	ICGC	LLYTPLNT	DEG_SCF_FBW7_1	703:710	Mutation altering degron motif	0.6752
p.P405T	TCGA-DD-A4NQ	LIHC	TCGA	EKHSCTVPEGL	DEG_COP1_1	392:402	Mutation rewiring degron network	0.25
p.P405T	DO44887	LIHC	ICGC	EKHSCTVPEGL	DEG_COP1_1	392:402	Mutation rewiring degron network	0.25
p.V410A	TCGA-DF-A2KN	UCEC	TCGA	EKHSCTVPEGL	DEG_COP1_1	392:402	Mutation rewiring degron network	0.1111
p.V410A	DO223282	UCEC	ICGC	EKHSCTVPEGL	DEG_COP1_1	392:402	Mutation rewiring degron network	0.1111
p.A406V	TCGA-DF-A2KN	UCEC	TCGA	EKHSCTVPEGL	DEG_COP1_1	392:402	Mutation rewiring degron network	0.2222
p.A406V	DO223282	UCEC	ICGC	EKHSCTVPEGL	DEG_COP1_1	392:402	Mutation rewiring degron network	0.2222
p.P812S	TCGA-EB-A41A	SKCM	TCGA	FKENQ	DEG_APCC_KENBOX_2	818:822	Mutation rewiring degron network	0.1667
p.P812S	DO37429	SKCM	ICGC	FKENQ	DEG_APCC_KENBOX_2	818:822	Mutation rewiring degron network	0.1667
p.G103W	TCGA-EE-A29P	SKCM	TCGA	DEETGE	DEG_Kelch_Keap1_1	89:94	Mutation rewiring degron network	0.0833
p.G103W	DO37916	SKCM	ICGC	DEETGE	DEG_Kelch_Keap1_1	89:94	Mutation rewiring degron network	0.0833
p.T710M	TCGA-EO-A22R	UCEC	TCGA	LLYTPLNT	DEG_SCF_FBW7_1	703:710	Mutation altering degron motif	0.7423
p.T710M	TCGA-WS-AB45	COAD	TCGA	LLYTPLNT	DEG_SCF_FBW7_1	703:710	Mutation altering degron motif	0.7423
p.T710M	DO51734	COAD	ICGC	LLYTPLNT	DEG_SCF_FBW7_1	703:710	Mutation altering degron motif	0.7423
p.T710M	DO42713	UCEC	ICGC	LLYTPLNT	DEG_SCF_FBW7_1	703:710	Mutation altering degron motif	0.7423
p.E91D	TCGA-EO-A3B0	UCEC	TCGA	DEETGE	DEG_Kelch_Keap1_1	89:94	Mutation altering degron motif	0.5647
p.E91D	DO219773	UCEC	ICGC	DEETGE	DEG_Kelch_Keap1_1	89:94	Mutation altering degron motif	0.5647
p.C828F	TCGA-F7-7848	HNSC	TCGA	FKENQ	DEG_APCC_KENBOX_2	818:822	Mutation rewiring degron network	0.1667
p.C828F	DO14198	HNSC	ICGC	FKENQ	DEG_APCC_KENBOX_2	818:822	Mutation rewiring degron network	0.1667
p.D714N	TCGA-XF-A9SP	BLCA	TCGA	LLYTPLNT	DEG_SCF_FBW7_1	703:710	Mutation rewiring degron network	0.2222
p.D714N	DO223598	BLCA	ICGC	LLYTPLNT	DEG_SCF_FBW7_1	703:710	Mutation rewiring degron network	0.2222
p.E392K	DO225392	BRCA	ICGC	EKHSCTVPEGL	DEG_COP1_1	392:402	Mutation altering degron motif	0.7022
p.Y409H	DO227987	COCA	ICGC	EKHSCTVPEGL	DEG_COP1_1	392:402	Mutation rewiring degron network	0.1389
p.S395T	DO222555	ESCA	ICGC	EKHSCTVPEGL	DEG_COP1_1	392:402	Mutation altering degron motif	0.6005
p.T696M	DO233885	GACA	ICGC	LLYTPLNT	DEG_SCF_FBW7_1	703:710	Mutation rewiring degron network	0.1389
p.A406E	DO229022	LICA	ICGC	EKHSCTVPEGL	DEG_COP1_1	392:402	Mutation rewiring degron network	0.2222
p.T96I	DO231871	LINC	ICGC	DEETGE	DEG_Kelch_Keap1_1	89:94	Mutation rewiring degron network	0.2778
p.P812L	DO222572	MELA	ICGC	FKENQ	DEG_APCC_KENBOX_2	818:822	Mutation rewiring degron network	0.1667
p.L703V	DO229137	NKTL	ICGC	LLYTPLNT	DEG_SCF_FBW7_1	703:710	Mutation altering degron motif	0.5654
p.L403V	DO221544	PACA	ICGC	EKHSCTVPEGL	DEG_COP1_1	392:402	Mutation rewiring degron network	0.3056
p.P388S	DO229465	SKCA	ICGC	EKHSCTVPEGL	DEG_COP1_1	392:402	Mutation rewiring degron network	0.2222
p.L100F	SIDM00459	B-Cell Non-Hodgkin's Lymphoma	GDSC	DEETGE	DEG_Kelch_Keap1_1	89:94	Mutation rewiring degron network	0.1667
p.L100F	OCI-LY7	haematopoietic and lymphoid tissue	COSMIC	DEETGE	DEG_Kelch_Keap1_1	89:94	Mutation rewiring degron network	0.1667
p.T720A	SIDM01064	Hodgkin's Lymphoma	GDSC	LLYTPLNT	DEG_SCF_FBW7_1	703:710	Mutation rewiring degron network	0.0556
p.T720A	ACH-000267	Lymphoma	CCLE	LLYTPLNT	DEG_SCF_FBW7_1	703:710	Mutation rewiring degron network	0.0556
p.T720A	HDLM-2	haematopoietic and lymphoid tissue	COSMIC	LLYTPLNT	DEG_SCF_FBW7_1	703:710	Mutation rewiring degron network	0.0556
p.L88V	SIDM01471	Chronic Myelogenous Leukemia	GDSC	DEETGE	DEG_Kelch_Keap1_1	89:94	Mutation rewiring degron network	0.3056
p.L88V	ACH-000604	Leukemia	CCLE	DEETGE	DEG_Kelch_Keap1_1	89:94	Mutation rewiring degron network	0.3056
p.S382I	ACH-001301	Neuroblastoma	CCLE	EKHSCTVPEGL	DEG_COP1_1	392:402	Mutation blocking phosphorylation signal	0.5
p.E695K	C-33-A	cervix	COSMIC	LLYTPLNT	DEG_SCF_FBW7_1	703:710	Mutation substituting flanking lysine	0.2222
p.V828M	22RV1	prostate	COSMIC	FKENQ	DEG_APCC_KENBOX_2	818:822	Mutation rewiring degron network	0.1667
p.P713L	NCI-H1770	lung	COSMIC	LLYTPLNT	DEG_SCF_FBW7_1	703:710	Mutation rewiring degron network	0.25

Kaplan plot for PALB2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PALB2

UniProt ID: Q86YC2

Entrez ID: 79728

Protein name: Partner and localizer of BRCA2

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PALB2 in