DegronMD

Uniprot ID: Q86YC2

Source protein: Partner and localizer of BRCA2

Source gene: PALB2

Class: DEG_COP1_1

Location: 392:402

E3 ligase: COP1

DEGRON score: 0.9597

ASA_SCORE: 87.7182

COIL: 0.8374

CONS_SCORE: 0.671

DSS_SCORE: 0.2905

HELIX: 0.0714

FCONS_SCORE: 1.0587

RIG_SCORE: 0.7379

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E384K	TCGA-BA-A4IG	HNSC	TCGA	EKHSCTVPEGL	DEG_COP1_1	0.1111
p.E384K	DO52028	HNSC	ICGC	EKHSCTVPEGL	DEG_COP1_1	0.1111
p.P405T	TCGA-DD-A4NQ	LIHC	TCGA	EKHSCTVPEGL	DEG_COP1_1	0.25
p.P405T	DO44887	LIHC	ICGC	EKHSCTVPEGL	DEG_COP1_1	0.25
p.V410A	TCGA-DF-A2KN	UCEC	TCGA	EKHSCTVPEGL	DEG_COP1_1	0.1111
p.V410A	DO223282	UCEC	ICGC	EKHSCTVPEGL	DEG_COP1_1	0.1111
p.A406V	TCGA-DF-A2KN	UCEC	TCGA	EKHSCTVPEGL	DEG_COP1_1	0.2222
p.A406V	DO223282	UCEC	ICGC	EKHSCTVPEGL	DEG_COP1_1	0.2222
p.E392K	DO225392	BRCA	ICGC	EKHSCTVPEGL	DEG_COP1_1	0.7022
p.Y409H	DO227987	COCA	ICGC	EKHSCTVPEGL	DEG_COP1_1	0.1389
p.S395T	DO222555	ESCA	ICGC	EKHSCTVPEGL	DEG_COP1_1	0.6005
p.A406E	DO229022	LICA	ICGC	EKHSCTVPEGL	DEG_COP1_1	0.2222
p.L403V	DO221544	PACA	ICGC	EKHSCTVPEGL	DEG_COP1_1	0.3056
p.P388S	DO229465	SKCA	ICGC	EKHSCTVPEGL	DEG_COP1_1	0.2222
p.S382I	ACH-001301	Neuroblastoma	CCLE	EKHSCTVPEGL	DEG_COP1_1	0.5

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86YC2	Partner and localizer of BRCA2	DEG_COP1_1	392:402	EKHSCTVPEGL	COP1	0.9597	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons