DegronMD

Uniprot ID: Q86YC2

Source protein: Partner and localizer of BRCA2

Source gene: PALB2

Class: DEG_SCF_FBW7_1

Location: 703:710

E3 ligase: FBXW7

DEGRON score: 0.589

ASA_SCORE: 94.25

COIL: 0.8565

CONS_SCORE: 0.5465

DSS_SCORE: 0.5027

HELIX: 0.0314

FCONS_SCORE: 1.2573

RIG_SCORE: 0.7573

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A712V	TCGA-06-5416	GBM	TCGA	LLYTPLNT	DEG_SCF_FBW7_1	0.2778
p.A712V	TCGA-XK-AAIW	PRAD	TCGA	LLYTPLNT	DEG_SCF_FBW7_1	0.2778
p.A712V	DO10880	GBM	ICGC	LLYTPLNT	DEG_SCF_FBW7_1	0.2778
p.A712V	DO51407	PRAD	ICGC	LLYTPLNT	DEG_SCF_FBW7_1	0.2778
p.A712V	SIDM01247	Burkitt's Lymphoma	GDSC	LLYTPLNT	DEG_SCF_FBW7_1	0.2778
p.P707S	TCGA-DA-A1HY	SKCM	TCGA	LLYTPLNT	DEG_SCF_FBW7_1	0.6752
p.P707S	DO37409	SKCM	ICGC	LLYTPLNT	DEG_SCF_FBW7_1	0.6752
p.T710M	TCGA-EO-A22R	UCEC	TCGA	LLYTPLNT	DEG_SCF_FBW7_1	0.7423
p.T710M	TCGA-WS-AB45	COAD	TCGA	LLYTPLNT	DEG_SCF_FBW7_1	0.7423
p.T710M	DO51734	COAD	ICGC	LLYTPLNT	DEG_SCF_FBW7_1	0.7423
p.T710M	DO42713	UCEC	ICGC	LLYTPLNT	DEG_SCF_FBW7_1	0.7423
p.D714N	TCGA-XF-A9SP	BLCA	TCGA	LLYTPLNT	DEG_SCF_FBW7_1	0.2222
p.D714N	DO223598	BLCA	ICGC	LLYTPLNT	DEG_SCF_FBW7_1	0.2222
p.T696M	DO233885	GACA	ICGC	LLYTPLNT	DEG_SCF_FBW7_1	0.1389
p.L703V	DO229137	NKTL	ICGC	LLYTPLNT	DEG_SCF_FBW7_1	0.5654
p.T720A	SIDM01064	Hodgkin's Lymphoma	GDSC	LLYTPLNT	DEG_SCF_FBW7_1	0.0556
p.T720A	ACH-000267	Lymphoma	CCLE	LLYTPLNT	DEG_SCF_FBW7_1	0.0556
p.T720A	HDLM-2	haematopoietic_and_lymphoid_tissue	COSMIC	LLYTPLNT	DEG_SCF_FBW7_1	0.0556
p.E695K	C-33-A	cervix	COSMIC	LLYTPLNT	DEG_SCF_FBW7_1	0.2222
p.P713L	NCI-H1770	lung	COSMIC	LLYTPLNT	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86YC2	Partner and localizer of BRCA2	DEG_SCF_FBW7_1	703:710	LLYTPLNT	FBXW7	0.589	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons