DegronMD

Uniprot ID: Q86YC2

Source protein: Partner and localizer of BRCA2

Source gene: PALB2

Class: DEG_Kelch_Keap1_1

Location: 89:94

E3 ligase: KEAP1

DEGRON score: 0.9881

ASA_SCORE: 103.6333

COIL: 0.7675

CONS_SCORE: 0.4962

DSS_SCORE: 0.4793

HELIX: 0.2145

FCONS_SCORE: 1.1437

RIG_SCORE: 0.7187

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G103W	TCGA-EE-A29P	SKCM	TCGA	DEETGE	DEG_Kelch_Keap1_1	0.0833
p.G103W	DO37916	SKCM	ICGC	DEETGE	DEG_Kelch_Keap1_1	0.0833
p.E91D	TCGA-EO-A3B0	UCEC	TCGA	DEETGE	DEG_Kelch_Keap1_1	0.5647
p.E91D	DO219773	UCEC	ICGC	DEETGE	DEG_Kelch_Keap1_1	0.5647
p.T96I	DO231871	LINC	ICGC	DEETGE	DEG_Kelch_Keap1_1	0.2778
p.L100F	SIDM00459	B-Cell Non-Hodgkin's Lymphoma	GDSC	DEETGE	DEG_Kelch_Keap1_1	0.1667
p.L100F	OCI-LY7	haematopoietic_and_lymphoid_tissue	COSMIC	DEETGE	DEG_Kelch_Keap1_1	0.1667
p.L88V	SIDM01471	Chronic Myelogenous Leukemia	GDSC	DEETGE	DEG_Kelch_Keap1_1	0.3056
p.L88V	ACH-000604	Leukemia	CCLE	DEETGE	DEG_Kelch_Keap1_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q16236	Nuclear factor erythroid 2-related factor 2	DEG_Kelch_Keap1_1	77:82	DEETGE	KEAP1	0.9862	More...
Q86YC2	Partner and localizer of BRCA2	DEG_Kelch_Keap1_1	89:94	DEETGE	KEAP1	0.9881	More...
Q96SB3	Neurabin-2	DEG_Kelch_Keap1_1	620:625	DEETGE	KEAP1	0.9966	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons