DegronMD - Q96SB3(PPP1R9B)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D618G	TCGA-43-A474	LUSC	TCGA	DEETGE	DEG_Kelch_Keap1_1	620:625	Mutation rewiring degron network	0.2778
p.D618G	DO45490	LUSC	ICGC	DEETGE	DEG_Kelch_Keap1_1	620:625	Mutation rewiring degron network	0.2778
p.E619K	TCGA-95-7948	LUAD	TCGA	DEETGE	DEG_Kelch_Keap1_1	620:625	Mutation rewiring degron network	0.3056
p.E619K	DO25133	LUAD	ICGC	DEETGE	DEG_Kelch_Keap1_1	620:625	Mutation rewiring degron network	0.3056
p.R486H	TCGA-AP-A0LD	UCEC	TCGA	ERLELFPVE	DEG_APCC_DBOX_1	490:498	Mutation rewiring degron network	0.2222
p.R486H	DO224731	COCA	ICGC	ERLELFPVE	DEG_APCC_DBOX_1	490:498	Mutation rewiring degron network	0.2222
p.R486H	DO41578	UCEC	ICGC	ERLELFPVE	DEG_APCC_DBOX_1	490:498	Mutation rewiring degron network	0.2222
p.R486H	ACH-000980	Lung Cancer	CCLE	ERLELFPVE	DEG_APCC_DBOX_1	490:498	Mutation rewiring degron network	0.2222
p.L497Q	TCGA-DA-A1HV	SKCM	TCGA	ERLELFPVE	DEG_APCC_DBOX_1	490:498	Mutation altering degron motif	0.7765
p.L497Q	DO37659	SKCM	ICGC	ERLELFPVE	DEG_APCC_DBOX_1	490:498	Mutation altering degron motif	0.7765
p.E616D	TCGA-EE-A2ML	SKCM	TCGA	DEETGE	DEG_Kelch_Keap1_1	620:625	Mutation rewiring degron network	0.2222
p.E616D	DO37408	SKCM	ICGC	DEETGE	DEG_Kelch_Keap1_1	620:625	Mutation rewiring degron network	0.2222
p.G622R	TCGA-EY-A5W2	UCEC	TCGA	DEETGE	DEG_Kelch_Keap1_1	620:625	Mutation altering degron motif	0.7568
p.G622R	DO48177	UCEC	ICGC	DEETGE	DEG_Kelch_Keap1_1	620:625	Mutation altering degron motif	0.7568
p.T621M	DO222700	BTCA	ICGC	DEETGE	DEG_Kelch_Keap1_1	620:625	Mutation altering degron motif	0.7423
p.E482K	DO233270	GACA	ICGC	ERLELFPVE	DEG_APCC_DBOX_1	490:498	Mutation rewiring degron network	0.1111
p.A612D	DO229029	LICA	ICGC	DEETGE	DEG_Kelch_Keap1_1	620:625	Mutation rewiring degron network	0.1111
p.T635K	DO229026	LICA	ICGC	DEETGE	DEG_Kelch_Keap1_1	620:625	Mutation rewiring degron network	0.0556
p.G615E	DO50970	LICA	ICGC	DEETGE	DEG_Kelch_Keap1_1	620:625	Mutation rewiring degron network	0.1944
p.A614T	SIDM00845	Burkitt's Lymphoma	GDSC	DEETGE	DEG_Kelch_Keap1_1	620:625	Mutation rewiring degron network	0.1667
p.R488H	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	ERLELFPVE	DEG_APCC_DBOX_1	490:498	Mutation rewiring degron network	0.2778
p.E493K	SIDM01503	Small Cell Lung Carcinoma	GDSC	ERLELFPVE	DEG_APCC_DBOX_1	490:498	Mutation altering degron motif	0.591
p.E500V	SIDM01617	Endometrial Carcinoma	GDSC	ERLELFPVE	DEG_APCC_DBOX_1	490:498	Mutation rewiring degron network	0.2778
p.A612T	ACH-000786	Lymphoma	CCLE	DEETGE	DEG_Kelch_Keap1_1	620:625	Mutation rewiring degron network	0.1111
p.E491K	ACH-000844	Lung Cancer	CCLE	ERLELFPVE	DEG_APCC_DBOX_1	490:498	Mutation altering degron motif	0.7022
p.D618E	ACH-000870	Lung Cancer	CCLE	DEETGE	DEG_Kelch_Keap1_1	620:625	Mutation rewiring degron network	0.2778
p.E498V	ACH-000994	Endometrial/Uterine Cancer	CCLE	ERLELFPVE	DEG_APCC_DBOX_1	490:498	Mutation altering degron motif	0.6582

Kaplan plot for PPP1R9B in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PPP1R9B

UniProt ID: Q96SB3

Entrez ID: 84687

Protein name: Neurabin-2 (Neurabin-II) (Protein phosphatase 1 regulatory subunit 9B) (Spinophilin)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for PPP1R9B in