DegronMD

Uniprot ID: Q96SB3

Source protein: Neurabin-2

Source gene: PPP1R9B

Class: DEG_APCC_DBOX_1

Location: 490:498

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.544

ASA_SCORE: 66.1556

COIL: 0.2032

CONS_SCORE: 0.7809

DSS_SCORE: 0.2842

HELIX: 0.0659

FCONS_SCORE: 0.9697

RIG_SCORE: 0.8617

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R486H	TCGA-AP-A0LD	UCEC	TCGA	ERLELFPVE	DEG_APCC_DBOX_1	0.2222
p.R486H	DO224731	COCA	ICGC	ERLELFPVE	DEG_APCC_DBOX_1	0.2222
p.R486H	DO41578	UCEC	ICGC	ERLELFPVE	DEG_APCC_DBOX_1	0.2222
p.R486H	ACH-000980	Lung Cancer	CCLE	ERLELFPVE	DEG_APCC_DBOX_1	0.2222
p.L497Q	TCGA-DA-A1HV	SKCM	TCGA	ERLELFPVE	DEG_APCC_DBOX_1	0.7765
p.L497Q	DO37659	SKCM	ICGC	ERLELFPVE	DEG_APCC_DBOX_1	0.7765
p.E482K	DO233270	GACA	ICGC	ERLELFPVE	DEG_APCC_DBOX_1	0.1111
p.R488H	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	ERLELFPVE	DEG_APCC_DBOX_1	0.2778
p.E493K	SIDM01503	Small Cell Lung Carcinoma	GDSC	ERLELFPVE	DEG_APCC_DBOX_1	0.591
p.E500V	SIDM01617	Endometrial Carcinoma	GDSC	ERLELFPVE	DEG_APCC_DBOX_1	0.2778
p.E491K	ACH-000844	Lung Cancer	CCLE	ERLELFPVE	DEG_APCC_DBOX_1	0.7022
p.E498V	ACH-000994	Endometrial/Uterine Cancer	CCLE	ERLELFPVE	DEG_APCC_DBOX_1	0.6582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96SB3	Neurabin-2	DEG_APCC_DBOX_1	490:498	ERLELFPVE	APC,CDC20,FZR1	0.544	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons