DegronMD

Uniprot ID: Q96SB3

Source protein: Neurabin-2

Source gene: PPP1R9B

Class: DEG_Kelch_Keap1_1

Location: 620:625

E3 ligase: KEAP1

DEGRON score: 0.9966

ASA_SCORE: 107.1333

COIL: 0.8185

CONS_SCORE: 0.4763

DSS_SCORE: 0.7843

HELIX: 0.1643

FCONS_SCORE: 1.1197

RIG_SCORE: 0.6664

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D618G	TCGA-43-A474	LUSC	TCGA	DEETGE	DEG_Kelch_Keap1_1	0.2778
p.D618G	DO45490	LUSC	ICGC	DEETGE	DEG_Kelch_Keap1_1	0.2778
p.E619K	TCGA-95-7948	LUAD	TCGA	DEETGE	DEG_Kelch_Keap1_1	0.3056
p.E619K	DO25133	LUAD	ICGC	DEETGE	DEG_Kelch_Keap1_1	0.3056
p.E616D	TCGA-EE-A2ML	SKCM	TCGA	DEETGE	DEG_Kelch_Keap1_1	0.2222
p.E616D	DO37408	SKCM	ICGC	DEETGE	DEG_Kelch_Keap1_1	0.2222
p.G622R	TCGA-EY-A5W2	UCEC	TCGA	DEETGE	DEG_Kelch_Keap1_1	0.7568
p.G622R	DO48177	UCEC	ICGC	DEETGE	DEG_Kelch_Keap1_1	0.7568
p.T621M	DO222700	BTCA	ICGC	DEETGE	DEG_Kelch_Keap1_1	0.7423
p.A612D	DO229029	LICA	ICGC	DEETGE	DEG_Kelch_Keap1_1	0.1111
p.T635K	DO229026	LICA	ICGC	DEETGE	DEG_Kelch_Keap1_1	0.0556
p.G615E	DO50970	LICA	ICGC	DEETGE	DEG_Kelch_Keap1_1	0.1944
p.A614T	SIDM00845	Burkitt's Lymphoma	GDSC	DEETGE	DEG_Kelch_Keap1_1	0.1667
p.A612T	ACH-000786	Lymphoma	CCLE	DEETGE	DEG_Kelch_Keap1_1	0.1111
p.D618E	ACH-000870	Lung Cancer	CCLE	DEETGE	DEG_Kelch_Keap1_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q16236	Nuclear factor erythroid 2-related factor 2	DEG_Kelch_Keap1_1	77:82	DEETGE	KEAP1	0.9862	More...
Q86YC2	Partner and localizer of BRCA2	DEG_Kelch_Keap1_1	89:94	DEETGE	KEAP1	0.9881	More...
Q96SB3	Neurabin-2	DEG_Kelch_Keap1_1	620:625	DEETGE	KEAP1	0.9966	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons