DegronMD

Uniprot ID: Q86YC2

Source protein: Partner and localizer of BRCA2

Source gene: PALB2

Class: DEG_APCC_KENBOX_2

Location: 818:822

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7398

ASA_SCORE: 107.68

COIL: 0.5038

CONS_SCORE: 0.4715

DSS_SCORE: 0.4213

HELIX: 0.4768

FCONS_SCORE: 1.0229

RIG_SCORE: 0.791

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E820Q	TCGA-43-A56V	LUSC	TCGA	FKENQ	DEG_APCC_KENBOX_2	0.6744
p.E820Q	DO45535	LUSC	ICGC	FKENQ	DEG_APCC_KENBOX_2	0.6744
p.P812S	TCGA-EB-A41A	SKCM	TCGA	FKENQ	DEG_APCC_KENBOX_2	0.1667
p.P812S	DO37429	SKCM	ICGC	FKENQ	DEG_APCC_KENBOX_2	0.1667
p.C828F	TCGA-F7-7848	HNSC	TCGA	FKENQ	DEG_APCC_KENBOX_2	0.1667
p.C828F	DO14198	HNSC	ICGC	FKENQ	DEG_APCC_KENBOX_2	0.1667
p.P812L	DO222572	MELA	ICGC	FKENQ	DEG_APCC_KENBOX_2	0.1667
p.V828M	22RV1	prostate	COSMIC	FKENQ	DEG_APCC_KENBOX_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5TB80	Centrosomal protein of 162 kDa	DEG_APCC_KENBOX_2	746:750	FKENQ	APC,CDC20,FZR1	0.6036	More...
Q86YC2	Partner and localizer of BRCA2	DEG_APCC_KENBOX_2	818:822	FKENQ	APC,CDC20,FZR1	0.7398	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons