DegronMD

Uniprot ID: Q5TB80

Source protein: Centrosomal protein of 162 kDa

Source gene: CEP162

Class: DEG_APCC_KENBOX_2

Location: 746:750

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6036

ASA_SCORE: 112.96

COIL: 0.0634

CONS_SCORE: 0.8558

DSS_SCORE: 0.4691

HELIX: 0.9384

FCONS_SCORE: 1.1446

RIG_SCORE: 0.7537

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F753L	SIDM00534	Colorectal Carcinoma	GDSC	FKENQ	DEG_APCC_KENBOX_2	0.25
p.F753L	HT-115	large_intestine	COSMIC	FKENQ	DEG_APCC_KENBOX_2	0.25
p.V756I	SIDM01763	Rhabdomyosarcoma	GDSC	FKENQ	DEG_APCC_KENBOX_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5TB80	Centrosomal protein of 162 kDa	DEG_APCC_KENBOX_2	746:750	FKENQ	APC,CDC20,FZR1	0.6036	More...
Q86YC2	Partner and localizer of BRCA2	DEG_APCC_KENBOX_2	818:822	FKENQ	APC,CDC20,FZR1	0.7398	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons