DegronMD - Q5TB80(CEP162)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P214L	SIDM00545	Melanoma	GDSC	SKENS	DEG_APCC_KENBOX_2	215:219	Mutation rewiring degron network	0.3056
p.P214L	Mewo	skin	COSMIC	SKENS	DEG_APCC_KENBOX_2	215:219	Mutation rewiring degron network	0.3056
p.N446D	SIDM00660	Colorectal Carcinoma	GDSC	VNSSS	DEG_SPOP_SBC_1	454:458	Mutation rewiring degron network	0.1111
p.N446D	LS-411N	large intestine	COSMIC	VNSSS	DEG_SPOP_SBC_1	454:458	Mutation rewiring degron network	0.1111
p.E217K	SIDM00797	Melanoma	GDSC	SKENS	DEG_APCC_KENBOX_2	215:219	Mutation altering degron motif	0.7022
p.E217K	A2058	skin	COSMIC	SKENS	DEG_APCC_KENBOX_2	215:219	Mutation altering degron motif	0.7022
p.F753L	SIDM00534	Colorectal Carcinoma	GDSC	FKENQ	DEG_APCC_KENBOX_2	746:750	Mutation rewiring degron network	0.25
p.F753L	HT-115	large intestine	COSMIC	FKENQ	DEG_APCC_KENBOX_2	746:750	Mutation rewiring degron network	0.25
p.Q461L	SIDM01387	Small Cell Lung Carcinoma	GDSC	VNSSS	DEG_SPOP_SBC_1	454:458	Mutation rewiring degron network	0.25
p.P205L	SIDM01424	B-Lymphoblastic Leukemia	GDSC	SKENS	DEG_APCC_KENBOX_2	215:219	Mutation rewiring degron network	0.0556
p.V756I	SIDM01763	Rhabdomyosarcoma	GDSC	FKENQ	DEG_APCC_KENBOX_2	746:750	Mutation rewiring degron network	0.1667
p.E453Q	NCI-H1417	lung	COSMIC	VNSSS	DEG_SPOP_SBC_1	454:458	Mutation rewiring degron network	0.3056
p.S468L	HT-115	large intestine	COSMIC	VNSSS	DEG_SPOP_SBC_1	454:458	Mutation rewiring degron network	0.0556

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons