DegronMD

Uniprot ID: Q5TB80

Source protein: Centrosomal protein of 162 kDa

Source gene: CEP162

Class: DEG_APCC_KENBOX_2

Location: 215:219

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.996

ASA_SCORE: 94.96

COIL: 0.5526

CONS_SCORE: 0.4514

DSS_SCORE: 0.6401

HELIX: 0.4266

FCONS_SCORE: 1.3886

RIG_SCORE: 0.6247

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P214L	SIDM00545	Melanoma	GDSC	SKENS	DEG_APCC_KENBOX_2	0.3056
p.P214L	Mewo	skin	COSMIC	SKENS	DEG_APCC_KENBOX_2	0.3056
p.E217K	SIDM00797	Melanoma	GDSC	SKENS	DEG_APCC_KENBOX_2	0.7022
p.E217K	A2058	skin	COSMIC	SKENS	DEG_APCC_KENBOX_2	0.7022
p.P205L	SIDM01424	B-Lymphoblastic Leukemia	GDSC	SKENS	DEG_APCC_KENBOX_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75592	E3 ubiquitin-protein ligase MYCBP2	DEG_APCC_KENBOX_2	3619:3623	SKENS	APC,CDC20,FZR1	0.9101	More...
O94966	Ubiquitin carboxyl-terminal hydrolase 19	DEG_APCC_KENBOX_2	704:708	SKENS	APC,CDC20,FZR1	0.6409	More...
Q5FWF5	N-acetyltransferase ESCO1	DEG_APCC_KENBOX_2	8:12	SKENS	APC,CDC20,FZR1	0.9682	More...
Q5TB80	Centrosomal protein of 162 kDa	DEG_APCC_KENBOX_2	215:219	SKENS	APC,CDC20,FZR1	0.996	More...
Q5BJE1	Coiled-coil domain-containing protein 178	DEG_APCC_KENBOX_2	53:57	SKENS	APC,CDC20,FZR1	0.8419	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons