DegronMD

Uniprot ID: O94966

Source protein: Ubiquitin carboxyl-terminal hydrolase 19

Source gene: USP19

Class: DEG_APCC_KENBOX_2

Location: 704:708

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6409

ASA_SCORE: 76.88

COIL: 0.8502

CONS_SCORE: 0.3528

DSS_SCORE: 0.1952

HELIX: 0.0418

FCONS_SCORE: 0.8414

RIG_SCORE: 0.7009

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R707H	TCGA-5M-AAT6	COAD	TCGA	SKENS	DEG_APCC_KENBOX_2	0.8244
p.R707H	TCGA-AA-A01R	COAD	TCGA	SKENS	DEG_APCC_KENBOX_2	0.8244
p.R707H	TCGA-AP-A1DV	UCEC	TCGA	SKENS	DEG_APCC_KENBOX_2	0.8244
p.R707H	SIDM00217	Colorectal Carcinoma	GDSC	SKENS	DEG_APCC_KENBOX_2	0.8244
p.R707H	ACH-000999	Colon/Colorectal Cancer	CCLE	SKENS	DEG_APCC_KENBOX_2	0.8244
p.R707H	SNU-1040	large_intestine	COSMIC	SKENS	DEG_APCC_KENBOX_2	0.8244
p.L697M	TCGA-CV-7415	HNSC	TCGA	SKENS	DEG_APCC_KENBOX_2	0.1389
p.G700W	TCGA-EE-A2MD	SKCM	TCGA	SKENS	DEG_APCC_KENBOX_2	0.2222
p.D704A	TCGA-EE-A3AB	SKCM	TCGA	SKENS	DEG_APCC_KENBOX_2	0.7793
p.G700E	TCGA-EO-A22U	UCEC	TCGA	SKENS	DEG_APCC_KENBOX_2	0.2222
p.K711T	TCGA-VQ-A8E3	STAD	TCGA	SKENS	DEG_APCC_KENBOX_2	0.25
p.L710I	DO8264	COAD	ICGC	SKENS	DEG_APCC_KENBOX_2	0.2778
p.L710I	DO41133	UCEC	ICGC	SKENS	DEG_APCC_KENBOX_2	0.2778
p.P708A	DO22938	LIHC	ICGC	SKENS	DEG_APCC_KENBOX_2	0.7503
p.L716F	DO32904	PACA	ICGC	SKENS	DEG_APCC_KENBOX_2	0.1111
p.L710F	DO218849	SKCA	ICGC	SKENS	DEG_APCC_KENBOX_2	0.2778
p.P708L	DO219764	UCEC	ICGC	SKENS	DEG_APCC_KENBOX_2	0.7582
p.T716I	SIDM01175	Other Sarcomas	GDSC	SKENS	DEG_APCC_KENBOX_2	0.1111
p.T716I	ACH-002309	Sarcoma	CCLE	SKENS	DEG_APCC_KENBOX_2	0.1111
p.T716I	SW684	soft_tissue	COSMIC	SKENS	DEG_APCC_KENBOX_2	0.1111
p.N710K	SIDM00795	Melanoma	GDSC	SKENS	DEG_APCC_KENBOX_2	0.2778
p.N710K	ACH-000219	Skin Cancer	CCLE	SKENS	DEG_APCC_KENBOX_2	0.2778
p.N710K	ACH-002001	Skin Cancer	CCLE	SKENS	DEG_APCC_KENBOX_2	0.2778
p.N710K	ACH-002002	Skin Cancer	CCLE	SKENS	DEG_APCC_KENBOX_2	0.2778
p.N710K	ACH-002003	Skin Cancer	CCLE	SKENS	DEG_APCC_KENBOX_2	0.2778
p.N710K	A375	skin	COSMIC	SKENS	DEG_APCC_KENBOX_2	0.2778
p.T706I	SW684	soft_tissue	COSMIC	SKENS	DEG_APCC_KENBOX_2	0.7078
p.A710V	KP-2	pancreas	COSMIC	SKENS	DEG_APCC_KENBOX_2	0.2778
p.N700K	A375	skin	COSMIC	SKENS	DEG_APCC_KENBOX_2	0.2222
p.R697H	SNU-1040	large_intestine	COSMIC	SKENS	DEG_APCC_KENBOX_2	0.1389
p.D707Y	42-MG-BA	central_nervous_system	COSMIC	SKENS	DEG_APCC_KENBOX_2	0.7325
p.T718I	SW684	soft_tissue	COSMIC	SKENS	DEG_APCC_KENBOX_2	0.0556
p.R709H	SNU-1040	large_intestine	COSMIC	SKENS	DEG_APCC_KENBOX_2	0.3056
p.N712K	A375	skin	COSMIC	SKENS	DEG_APCC_KENBOX_2	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75592	E3 ubiquitin-protein ligase MYCBP2	DEG_APCC_KENBOX_2	3619:3623	SKENS	APC,CDC20,FZR1	0.9101	More...
O94966	Ubiquitin carboxyl-terminal hydrolase 19	DEG_APCC_KENBOX_2	704:708	SKENS	APC,CDC20,FZR1	0.6409	More...
Q5FWF5	N-acetyltransferase ESCO1	DEG_APCC_KENBOX_2	8:12	SKENS	APC,CDC20,FZR1	0.9682	More...
Q5TB80	Centrosomal protein of 162 kDa	DEG_APCC_KENBOX_2	215:219	SKENS	APC,CDC20,FZR1	0.996	More...
Q5BJE1	Coiled-coil domain-containing protein 178	DEG_APCC_KENBOX_2	53:57	SKENS	APC,CDC20,FZR1	0.8419	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SKENS

Degron related mutations and impact score

Drug responses associated with USP19 mutations

All proteins holding degron of SKENS