DegronMD

Uniprot ID: Q9H158

Source protein: Protocadherin alpha-C1

Source gene: PCDHAC1

Class: DEG_SPOP_SBC_1

Location: 500:504

E3 ligase: SPOP

DEGRON score: 0.5524

ASA_SCORE: 50.06

COIL: 0.6306

CONS_SCORE: 0.5487

DSS_SCORE: 0.276

HELIX: 0.0134

FCONS_SCORE: 0.9789

RIG_SCORE: 0.7234

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G491W	TCGA-AP-A0LM	UCEC	TCGA	VESSS	DEG_SPOP_SBC_1	0.0833
p.G491W	DO43306	UCEC	ICGC	VESSS	DEG_SPOP_SBC_1	0.0833
p.T508A	TCGA-BR-8059	STAD	TCGA	VESSS	DEG_SPOP_SBC_1	0.2222
p.T508A	DO38443	STAD	ICGC	VESSS	DEG_SPOP_SBC_1	0.2222
p.S493L	TCGA-C4-A0EZ	BLCA	TCGA	VESSS	DEG_SPOP_SBC_1	0.1389
p.S493L	DO476	BLCA	ICGC	VESSS	DEG_SPOP_SBC_1	0.1389
p.A506V	TCGA-CV-A461	HNSC	TCGA	VESSS	DEG_SPOP_SBC_1	0.2778
p.A506V	DO49058	HNSC	ICGC	VESSS	DEG_SPOP_SBC_1	0.2778
p.S512F	TCGA-EE-A2GC	SKCM	TCGA	VESSS	DEG_SPOP_SBC_1	0.1111
p.S512F	TCGA-EE-A3AG	SKCM	TCGA	VESSS	DEG_SPOP_SBC_1	0.1111
p.S512F	DO37839	SKCM	ICGC	VESSS	DEG_SPOP_SBC_1	0.1111
p.S512F	DO37471	SKCM	ICGC	VESSS	DEG_SPOP_SBC_1	0.1111
p.L498V	DO222990	BTCA	ICGC	VESSS	DEG_SPOP_SBC_1	0.2778
p.L498V	DO229010	COCA	ICGC	VESSS	DEG_SPOP_SBC_1	0.2778
p.L498V	DO229016	COCA	ICGC	VESSS	DEG_SPOP_SBC_1	0.2778
p.L498V	DO229003	COCA	ICGC	VESSS	DEG_SPOP_SBC_1	0.2778
p.L498V	DO229005	COCA	ICGC	VESSS	DEG_SPOP_SBC_1	0.2778
p.L498V	DO230659	LAML	ICGC	VESSS	DEG_SPOP_SBC_1	0.2778
p.L498V	DO225404	LAML	ICGC	VESSS	DEG_SPOP_SBC_1	0.2778
p.L498V	DO231140	LAML	ICGC	VESSS	DEG_SPOP_SBC_1	0.2778
p.L498V	DO230990	LUSC	ICGC	VESSS	DEG_SPOP_SBC_1	0.2778
p.S496I	DO233296	NACA	ICGC	VESSS	DEG_SPOP_SBC_1	0.2222
p.S496N	SIDM01126	Small Cell Lung Carcinoma	GDSC	VESSS	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P38398	Breast cancer type 1 susceptibility protein	DEG_SPOP_SBC_1	764:768	VESSS	SPOP	0.9922	More...
P46100	Transcriptional regulator ATRX	DEG_SPOP_SBC_1	556:560	VESSS	SPOP	0.9969	More...
Q16236	Nuclear factor erythroid 2-related factor 2	DEG_SPOP_SBC_1	361:365	VESSS	SPOP	0.9641	More...
Q58EX7	Puratrophin-1	DEG_SPOP_SBC_1	87:91	VESSS	SPOP	0.97	More...
Q6ZW76	Ankyrin repeat and SAM domain-containing protein 3	DEG_SPOP_SBC_1	327:331	VESSS	SPOP	0.9989	More...
Q86XP1	Diacylglycerol kinase eta	DEG_SPOP_SBC_1	584:588	VESSS	SPOP	0.7501	More...
Q8N108	Mesoderm induction early response protein 1	DEG_SPOP_SBC_1	6:10	VESSS	SPOP	0.7443	More...
Q8N5B7	Ceramide synthase 5	DEG_SPOP_SBC_1	352:356	VESSS	SPOP	0.6322	More...
Q8NEM8	Cytosolic carboxypeptidase 3	DEG_SPOP_SBC_1	611:615	VESSS	SPOP	0.7484	More...
Q8NFG4	Folliculin	DEG_SPOP_SBC_1	69:73	VESSS	SPOP	0.5048	More...
Q9H4Z2	Zinc finger protein 335	DEG_SPOP_SBC_1	6:10	VESSS	SPOP	0.5869	More...
Q9P272	Probable tRNA methyltransferase 9B	DEG_SPOP_SBC_1	313:317	VESSS	SPOP	0.7748	More...
Q9UHY1	Nuclear receptor-binding protein	DEG_SPOP_SBC_1	18:22	VESSS	SPOP	0.9939	More...
Q8NCQ7	Protein PROCA1	DEG_SPOP_SBC_1	323:327	VESSS	SPOP	0.5806	More...
Q9H158	Protocadherin alpha-C1	DEG_SPOP_SBC_1	500:504	VESSS	SPOP	0.5524	More...
Q5TG30	Rho GTPase-activating protein 40	DEG_SPOP_SBC_1	24:28	VESSS	SPOP	0.9601	More...
Q8NDA8	Maestro heat-like repeat-containing protein family member 1	DEG_SPOP_SBC_1	321:325	VESSS	SPOP	0.5715	More...
A8MU93	Uncharacterized protein C17orf100	DEG_SPOP_SBC_1	71:75	VESSS	SPOP	0.9225	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VESSS

Degron related mutations and impact score

Drug responses associated with PCDHAC1 mutations

All proteins holding degron of VESSS