DegronMD - Q8N108(MIER1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P429S	TCGA-AJ-A3BH	UCEC	TCGA	KKPLHAD	LIG_APCC_ABBAyCdc20_2	434:440	Mutation rewiring degron network	0.1944
p.G15D	TCGA-AP-A1DK	UCEC	TCGA	VESSS	DEG_SPOP_SBC_1	6:10	Mutation rewiring degron network	0.1944
p.G15D	DO42033	UCEC	ICGC	VESSS	DEG_SPOP_SBC_1	6:10	Mutation rewiring degron network	0.1944
p.D447N	TCGA-AX-A1CE	UCEC	TCGA	KKPLHAD	LIG_APCC_ABBAyCdc20_2	434:440	Mutation rewiring degron network	0.1389
p.P431T	TCGA-BQ-7044	KIRP	TCGA	KKPLHAD	LIG_APCC_ABBAyCdc20_2	434:440	Mutation rewiring degron network	0.25
p.R427L	TCGA-D3-A3CE	SKCM	TCGA	KKPLHAD	LIG_APCC_ABBAyCdc20_2	434:440	Mutation rewiring degron network	0.1389
p.G3R	TCGA-EO-A22R	UCEC	TCGA	VESSS	DEG_SPOP_SBC_1	6:10	Mutation rewiring degron network	0.25
p.G3R	DO42713	UCEC	ICGC	VESSS	DEG_SPOP_SBC_1	6:10	Mutation rewiring degron network	0.25
p.G12V	DO558	BLCA	ICGC	VESSS	DEG_SPOP_SBC_1	6:10	Mutation rewiring degron network	0.2778
p.G12V	DO51512	PACA	ICGC	VESSS	DEG_SPOP_SBC_1	6:10	Mutation rewiring degron network	0.2778
p.N450D	DO10140	COAD	ICGC	KKPLHAD	LIG_APCC_ABBAyCdc20_2	434:440	Mutation rewiring degron network	0.0556
p.S10C	DO48320	ESCA	ICGC	VESSS	DEG_SPOP_SBC_1	6:10	Mutation altering degron motif	0.8652
p.N433K	DO228536	GACA	ICGC	KKPLHAD	LIG_APCC_ABBAyCdc20_2	434:440	Mutation rewiring degron network	0.3056
p.H438L	DO233735	GACA	ICGC	KKPLHAD	LIG_APCC_ABBAyCdc20_2	434:440	Mutation altering degron motif	0.7313
p.I426S	DO17303	KIRC	ICGC	KKPLHAD	LIG_APCC_ABBAyCdc20_2	434:440	Mutation rewiring degron network	0.1111
p.Y446S	DO45139	LIRI	ICGC	KKPLHAD	LIG_APCC_ABBAyCdc20_2	434:440	Mutation rewiring degron network	0.1667
p.S5F	DO51482	PACA	ICGC	VESSS	DEG_SPOP_SBC_1	6:10	Mutation rewiring degron network	0.3056
p.S17L	DO37567	SKCM	ICGC	VESSS	DEG_SPOP_SBC_1	6:10	Mutation rewiring degron network	0.1389
p.K435N	DO38495	STAD	ICGC	KKPLHAD	LIG_APCC_ABBAyCdc20_2	434:440	Mutation altering degron motif	0.5806
p.N5K	DO229232	THCA	ICGC	VESSS	DEG_SPOP_SBC_1	6:10	Mutation rewiring degron network	0.3056
p.Q20H	DO41999	UCEC	ICGC	VESSS	DEG_SPOP_SBC_1	6:10	Mutation rewiring degron network	0.0556
p.T13I	SIDM00845	Burkitt's Lymphoma	GDSC	VESSS	DEG_SPOP_SBC_1	6:10	Mutation rewiring degron network	0.25
p.T13I	SIDM00461	Acute Myeloid Leukemia	GDSC	VESSS	DEG_SPOP_SBC_1	6:10	Mutation rewiring degron network	0.25
p.T13I	SIDM00946	T-Lymphoblastic Leukemia	GDSC	VESSS	DEG_SPOP_SBC_1	6:10	Mutation rewiring degron network	0.25
p.T13I	Daudi	haematopoietic and lymphoid tissue	COSMIC	VESSS	DEG_SPOP_SBC_1	6:10	Mutation rewiring degron network	0.25
p.Q20K	SIDM00845	Burkitt's Lymphoma	GDSC	VESSS	DEG_SPOP_SBC_1	6:10	Mutation rewiring degron network	0.0556
p.Q20K	SIDM00461	Acute Myeloid Leukemia	GDSC	VESSS	DEG_SPOP_SBC_1	6:10	Mutation rewiring degron network	0.0556
p.Q20K	Daudi	haematopoietic and lymphoid tissue	COSMIC	VESSS	DEG_SPOP_SBC_1	6:10	Mutation rewiring degron network	0.0556
p.H438P	ACH-000856	Breast Cancer	CCLE	KKPLHAD	LIG_APCC_ABBAyCdc20_2	434:440	Mutation altering degron motif	0.7694
p.H438P	CAL-51	breast	COSMIC	KKPLHAD	LIG_APCC_ABBAyCdc20_2	434:440	Mutation altering degron motif	0.7694
p.D449N	ACH-000992	Head and Neck Cancer	CCLE	KKPLHAD	LIG_APCC_ABBAyCdc20_2	434:440	Mutation rewiring degron network	0.0833
p.T16A	P30-OHK	haematopoietic and lymphoid tissue	COSMIC	VESSS	DEG_SPOP_SBC_1	6:10	Mutation rewiring degron network	0.1667
p.S439I	CMK	haematopoietic and lymphoid tissue	COSMIC	KKPLHAD	LIG_APCC_ABBAyCdc20_2	434:440	Mutation altering degron motif	0.7341

Kaplan plot for MIER1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MIER1

UniProt ID: Q8N108

Entrez ID: 57708

Protein name: Mesoderm induction early response protein 1 (Early response 1) (Er1) (Mi-er1) (hMi-er1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MIER1 in