DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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CGC
Degron:
KKPLHAD
Uniprot ID:
Q8N108
Source protein:
Mesoderm induction early response protein 1
Source gene:
MIER1
Class:
LIG_APCC_ABBAyCdc20_2
Location:
434:440
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.8474
ASA_SCORE:
102.6286
COIL:
0.8353
CONS_SCORE:
0.3368
DSS_SCORE:
0.6253
HELIX:
0.1263
FCONS_SCORE:
0.9329
RIG_SCORE:
0.687
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P429S
TCGA-AJ-A3BH
UCEC
TCGA
KKPLHAD
LIG_APCC_ABBAyCdc20_2
0.1944
p.D447N
TCGA-AX-A1CE
UCEC
TCGA
KKPLHAD
LIG_APCC_ABBAyCdc20_2
0.1389
p.P431T
TCGA-BQ-7044
KIRP
TCGA
KKPLHAD
LIG_APCC_ABBAyCdc20_2
0.25
p.R427L
TCGA-D3-A3CE
SKCM
TCGA
KKPLHAD
LIG_APCC_ABBAyCdc20_2
0.1389
p.N450D
DO10140
COAD
ICGC
KKPLHAD
LIG_APCC_ABBAyCdc20_2
0.0556
p.N433K
DO228536
GACA
ICGC
KKPLHAD
LIG_APCC_ABBAyCdc20_2
0.3056
p.H438L
DO233735
GACA
ICGC
KKPLHAD
LIG_APCC_ABBAyCdc20_2
0.7313
p.I426S
DO17303
KIRC
ICGC
KKPLHAD
LIG_APCC_ABBAyCdc20_2
0.1111
p.Y446S
DO45139
LIRI
ICGC
KKPLHAD
LIG_APCC_ABBAyCdc20_2
0.1667
p.K435N
DO38495
STAD
ICGC
KKPLHAD
LIG_APCC_ABBAyCdc20_2
0.5806
p.H438P
ACH-000856
Breast Cancer
CCLE
KKPLHAD
LIG_APCC_ABBAyCdc20_2
0.7694
p.H438P
CAL-51
breast
COSMIC
KKPLHAD
LIG_APCC_ABBAyCdc20_2
0.7694
p.D449N
ACH-000992
Head and Neck Cancer
CCLE
KKPLHAD
LIG_APCC_ABBAyCdc20_2
0.0833
p.S439I
CMK
haematopoietic_and_lymphoid_tissue
COSMIC
KKPLHAD
LIG_APCC_ABBAyCdc20_2
0.7341
Drug responses associated with MIER1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of KKPLHAD
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8N108
Mesoderm induction early response protein 1
LIG_APCC_ABBAyCdc20_2
434:440
KKPLHAD
APC,CDC20,FZR1
0.8474
More...