DegronMD - Q86XP1(DGKH)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q905K	TCGA-43-3394	LUSC	TCGA	KITIFGD	LIG_APCC_ABBAyCdc20_2	910:916	Mutation rewiring degron network	0.1944
p.A583D	TCGA-AA-A02R	COAD	TCGA	VESSS	DEG_SPOP_SBC_1	584:588	Mutation rewiring degron network	0.3056
p.I913V	TCGA-CV-6952	HNSC	TCGA	KITIFGD	LIG_APCC_ABBAyCdc20_2	910:916	Mutation altering degron motif	0.5965
p.Q905H	TCGA-EE-A2MQ	SKCM	TCGA	KITIFGD	LIG_APCC_ABBAyCdc20_2	910:916	Mutation rewiring degron network	0.1944
p.E581K	TCGA-EE-A3JD	SKCM	TCGA	VESSS	DEG_SPOP_SBC_1	584:588	Mutation rewiring degron network	0.25
p.E917K	TCGA-EO-A22X	UCEC	TCGA	KITIFGD	LIG_APCC_ABBAyCdc20_2	910:916	Mutation rewiring degron network	0.3056
p.E926K	TCGA-SY-A9G5	BLCA	TCGA	KITIFGD	LIG_APCC_ABBAyCdc20_2	910:916	Mutation rewiring degron network	0.0556
p.T912S	DO48378	BLCA	ICGC	KITIFGD	LIG_APCC_ABBAyCdc20_2	910:916	Mutation altering degron motif	0.6005
p.A597T	DO912	BOCA	ICGC	VESSS	DEG_SPOP_SBC_1	584:588	Mutation rewiring degron network	0.0833
p.A920V	DO225346	BRCA	ICGC	KITIFGD	LIG_APCC_ABBAyCdc20_2	910:916	Mutation rewiring degron network	0.2222
p.A920V	DO234350	ESAD	ICGC	KITIFGD	LIG_APCC_ABBAyCdc20_2	910:916	Mutation rewiring degron network	0.2222
p.A920V	DO41331	UCEC	ICGC	KITIFGD	LIG_APCC_ABBAyCdc20_2	910:916	Mutation rewiring degron network	0.2222
p.L592P	DO224654	BRCA	ICGC	VESSS	DEG_SPOP_SBC_1	584:588	Mutation rewiring degron network	0.2222
p.R582I	DO8690	COAD	ICGC	VESSS	DEG_SPOP_SBC_1	584:588	Mutation rewiring degron network	0.2778
p.E908K	DO8264	COAD	ICGC	KITIFGD	LIG_APCC_ABBAyCdc20_2	910:916	Mutation rewiring degron network	0.2778
p.E908K	DO222875	MELA	ICGC	KITIFGD	LIG_APCC_ABBAyCdc20_2	910:916	Mutation rewiring degron network	0.2778
p.E908K	DO41020	UCEC	ICGC	KITIFGD	LIG_APCC_ABBAyCdc20_2	910:916	Mutation rewiring degron network	0.2778
p.E908K	DO41903	UCEC	ICGC	KITIFGD	LIG_APCC_ABBAyCdc20_2	910:916	Mutation rewiring degron network	0.2778
p.C912R	DO233782	GACA	ICGC	KITIFGD	LIG_APCC_ABBAyCdc20_2	910:916	Mutation altering degron motif	0.8301
p.P577H	DO14226	HNSC	ICGC	VESSS	DEG_SPOP_SBC_1	584:588	Mutation rewiring degron network	0.1389
p.A593S	DO228971	LICA	ICGC	VESSS	DEG_SPOP_SBC_1	584:588	Mutation rewiring degron network	0.1944
p.C902F	DO229036	LICA	ICGC	KITIFGD	LIG_APCC_ABBAyCdc20_2	910:916	Mutation rewiring degron network	0.1111
p.P903L	DO224566	LUSC	ICGC	KITIFGD	LIG_APCC_ABBAyCdc20_2	910:916	Mutation rewiring degron network	0.1389
p.P903L	DO231007	LUSC	ICGC	KITIFGD	LIG_APCC_ABBAyCdc20_2	910:916	Mutation rewiring degron network	0.1389
p.A915V	DO222880	MELA	ICGC	KITIFGD	LIG_APCC_ABBAyCdc20_2	910:916	Mutation altering degron motif	0.6936
p.T907K	DO46354	OV	ICGC	KITIFGD	LIG_APCC_ABBAyCdc20_2	910:916	Mutation rewiring degron network	0.25
p.G598A	DO30570	OV	ICGC	VESSS	DEG_SPOP_SBC_1	584:588	Mutation rewiring degron network	0.0556
p.D916G	SIDM00217	Colorectal Carcinoma	GDSC	KITIFGD	LIG_APCC_ABBAyCdc20_2	910:916	Mutation altering degron motif	0.7198
p.D916G	ACH-000999	Colon/Colorectal Cancer	CCLE	KITIFGD	LIG_APCC_ABBAyCdc20_2	910:916	Mutation altering degron motif	0.7198
p.D916G	SNU-1040	large intestine	COSMIC	KITIFGD	LIG_APCC_ABBAyCdc20_2	910:916	Mutation altering degron motif	0.7198

Kaplan plot for DGKH in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DGKH

UniProt ID: Q86XP1

Entrez ID: 160851

Protein name: Diacylglycerol kinase eta (DAG kinase eta) (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DGKH in