DegronMD

Uniprot ID: Q86XP1

Source protein: Diacylglycerol kinase eta

Source gene: DGKH

Class: LIG_APCC_ABBAyCdc20_2

Location: 910:916

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6496

ASA_SCORE: 50.8429

COIL: 0.3819

CONS_SCORE: 0.5206

DSS_SCORE: 0.132

HELIX: 0.0091

FCONS_SCORE: 0.8719

RIG_SCORE: 0.8632

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q905K	TCGA-43-3394	LUSC	TCGA	KITIFGD	LIG_APCC_ABBAyCdc20_2	0.1944
p.I913V	TCGA-CV-6952	HNSC	TCGA	KITIFGD	LIG_APCC_ABBAyCdc20_2	0.5965
p.Q905H	TCGA-EE-A2MQ	SKCM	TCGA	KITIFGD	LIG_APCC_ABBAyCdc20_2	0.1944
p.E917K	TCGA-EO-A22X	UCEC	TCGA	KITIFGD	LIG_APCC_ABBAyCdc20_2	0.3056
p.E926K	TCGA-SY-A9G5	BLCA	TCGA	KITIFGD	LIG_APCC_ABBAyCdc20_2	0.0556
p.T912S	DO48378	BLCA	ICGC	KITIFGD	LIG_APCC_ABBAyCdc20_2	0.6005
p.A920V	DO225346	BRCA	ICGC	KITIFGD	LIG_APCC_ABBAyCdc20_2	0.2222
p.A920V	DO234350	ESAD	ICGC	KITIFGD	LIG_APCC_ABBAyCdc20_2	0.2222
p.A920V	DO41331	UCEC	ICGC	KITIFGD	LIG_APCC_ABBAyCdc20_2	0.2222
p.E908K	DO8264	COAD	ICGC	KITIFGD	LIG_APCC_ABBAyCdc20_2	0.2778
p.E908K	DO222875	MELA	ICGC	KITIFGD	LIG_APCC_ABBAyCdc20_2	0.2778
p.E908K	DO41020	UCEC	ICGC	KITIFGD	LIG_APCC_ABBAyCdc20_2	0.2778
p.E908K	DO41903	UCEC	ICGC	KITIFGD	LIG_APCC_ABBAyCdc20_2	0.2778
p.C912R	DO233782	GACA	ICGC	KITIFGD	LIG_APCC_ABBAyCdc20_2	0.8301
p.C902F	DO229036	LICA	ICGC	KITIFGD	LIG_APCC_ABBAyCdc20_2	0.1111
p.P903L	DO224566	LUSC	ICGC	KITIFGD	LIG_APCC_ABBAyCdc20_2	0.1389
p.P903L	DO231007	LUSC	ICGC	KITIFGD	LIG_APCC_ABBAyCdc20_2	0.1389
p.A915V	DO222880	MELA	ICGC	KITIFGD	LIG_APCC_ABBAyCdc20_2	0.6936
p.T907K	DO46354	OV	ICGC	KITIFGD	LIG_APCC_ABBAyCdc20_2	0.25
p.D916G	SIDM00217	Colorectal Carcinoma	GDSC	KITIFGD	LIG_APCC_ABBAyCdc20_2	0.7198
p.D916G	ACH-000999	Colon/Colorectal Cancer	CCLE	KITIFGD	LIG_APCC_ABBAyCdc20_2	0.7198
p.D916G	SNU-1040	large_intestine	COSMIC	KITIFGD	LIG_APCC_ABBAyCdc20_2	0.7198

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86XP1	Diacylglycerol kinase eta	LIG_APCC_ABBAyCdc20_2	910:916	KITIFGD	APC,CDC20,FZR1	0.6496	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons