DegronMD - Q9H158(PCDHAC1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S162I	TCGA-85-8584	LUSC	TCGA	NGILSYSLSP	CBL_PTK	156:165	Mutation altering degron motif	0.7341
p.S162I	DO45438	LUSC	ICGC	NGILSYSLSP	CBL_PTK	156:165	Mutation altering degron motif	0.7341
p.D172N	TCGA-AN-A046	BRCA	TCGA	NGILSYSLSP	CBL_PTK	156:165	Mutation rewiring degron network	0.1389
p.D172N	DO1285	BRCA	ICGC	NGILSYSLSP	CBL_PTK	156:165	Mutation rewiring degron network	0.1389
p.G491W	TCGA-AP-A0LM	UCEC	TCGA	VESSS	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.0833
p.G491W	DO43306	UCEC	ICGC	VESSS	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.0833
p.T508A	TCGA-BR-8059	STAD	TCGA	VESSS	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.2222
p.T508A	DO38443	STAD	ICGC	VESSS	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.2222
p.S493L	TCGA-C4-A0EZ	BLCA	TCGA	VESSS	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.1389
p.S493L	DO476	BLCA	ICGC	VESSS	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.1389
p.A506V	TCGA-CV-A461	HNSC	TCGA	VESSS	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.2778
p.A506V	DO49058	HNSC	ICGC	VESSS	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.2778
p.S512F	TCGA-EE-A2GC	SKCM	TCGA	VESSS	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.1111
p.S512F	TCGA-EE-A3AG	SKCM	TCGA	VESSS	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.1111
p.S512F	DO37839	SKCM	ICGC	VESSS	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.1111
p.S512F	DO37471	SKCM	ICGC	VESSS	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.1111
p.S160I	TCGA-EO-A22X	UCEC	TCGA	NGILSYSLSP	CBL_PTK	156:165	Mutation altering degron motif	0.623
p.S160I	DO43907	UCEC	ICGC	NGILSYSLSP	CBL_PTK	156:165	Mutation altering degron motif	0.623
p.F169Y	TCGA-Z2-A8RT	SKCM	TCGA	NGILSYSLSP	CBL_PTK	156:165	Mutation rewiring degron network	0.2222
p.F169Y	DO51301	SKCM	ICGC	NGILSYSLSP	CBL_PTK	156:165	Mutation rewiring degron network	0.2222
p.L498V	DO222990	BTCA	ICGC	VESSS	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.2778
p.L498V	DO229010	COCA	ICGC	VESSS	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.2778
p.L498V	DO229016	COCA	ICGC	VESSS	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.2778
p.L498V	DO229003	COCA	ICGC	VESSS	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.2778
p.L498V	DO229005	COCA	ICGC	VESSS	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.2778
p.L498V	DO230659	LAML	ICGC	VESSS	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.2778
p.L498V	DO225404	LAML	ICGC	VESSS	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.2778
p.L498V	DO231140	LAML	ICGC	VESSS	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.2778
p.L498V	DO230990	LUSC	ICGC	VESSS	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.2778
p.D151Y	DO223007	ESCA	ICGC	NGILSYSLSP	CBL_PTK	156:165	Mutation rewiring degron network	0.1944
p.A148T	DO50807	LIRI	ICGC	NGILSYSLSP	CBL_PTK	156:165	Mutation rewiring degron network	0.1111
p.A148T	SIDM01007	T-Lymphoblastic Leukemia	GDSC	NGILSYSLSP	CBL_PTK	156:165	Mutation rewiring degron network	0.1111
p.A148T	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	NGILSYSLSP	CBL_PTK	156:165	Mutation rewiring degron network	0.1111
p.S175L	DO222578	MELA	ICGC	NGILSYSLSP	CBL_PTK	156:165	Mutation rewiring degron network	0.0556
p.S496I	DO233296	NACA	ICGC	VESSS	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.2222
p.R170C	DO227569	PBCA	ICGC	NGILSYSLSP	CBL_PTK	156:165	Mutation rewiring degron network	0.1944
p.G157R	DO218874	SKCA	ICGC	NGILSYSLSP	CBL_PTK	156:165	Mutation altering degron motif	0.6457
p.S496N	SIDM01126	Small Cell Lung Carcinoma	GDSC	VESSS	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.2222
p.L159P	SIDM00449	B-Lymphoblastic Leukemia	GDSC	NGILSYSLSP	CBL_PTK	156:165	Mutation altering degron motif	0.6471
p.H168R	SIDM00217	Colorectal Carcinoma	GDSC	NGILSYSLSP	CBL_PTK	156:165	Mutation rewiring degron network	0.25
p.H168R	ACH-000999	Colon/Colorectal Cancer	CCLE	NGILSYSLSP	CBL_PTK	156:165	Mutation rewiring degron network	0.25
p.H168R	SNU-1040	large intestine	COSMIC	NGILSYSLSP	CBL_PTK	156:165	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PCDHAC1

UniProt ID: Q9H158

Entrez ID: 56135

Protein name: Protocadherin alpha-C1 (PCDH-alpha-C1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PCDHAC1 in