DegronMD

Uniprot ID: Q9H158

Source protein: Protocadherin alpha-C1

Source gene: PCDHAC1

Class: CBL_PTK

Location: 156:165

E3 ligase: CBL

DEGRON score: 0.5532

ASA_SCORE: 54.29

COIL: 0.5254

CONS_SCORE: 0.5512

DSS_SCORE: 0.5076

HELIX: 0.0369

FCONS_SCORE: 0.9017

RIG_SCORE: 0.6951

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S162I	TCGA-85-8584	LUSC	TCGA	NGILSYSLSP	CBL_PTK	0.7341
p.S162I	DO45438	LUSC	ICGC	NGILSYSLSP	CBL_PTK	0.7341
p.D172N	TCGA-AN-A046	BRCA	TCGA	NGILSYSLSP	CBL_PTK	0.1389
p.D172N	DO1285	BRCA	ICGC	NGILSYSLSP	CBL_PTK	0.1389
p.S160I	TCGA-EO-A22X	UCEC	TCGA	NGILSYSLSP	CBL_PTK	0.623
p.S160I	DO43907	UCEC	ICGC	NGILSYSLSP	CBL_PTK	0.623
p.F169Y	TCGA-Z2-A8RT	SKCM	TCGA	NGILSYSLSP	CBL_PTK	0.2222
p.F169Y	DO51301	SKCM	ICGC	NGILSYSLSP	CBL_PTK	0.2222
p.D151Y	DO223007	ESCA	ICGC	NGILSYSLSP	CBL_PTK	0.1944
p.A148T	DO50807	LIRI	ICGC	NGILSYSLSP	CBL_PTK	0.1111
p.A148T	SIDM01007	T-Lymphoblastic Leukemia	GDSC	NGILSYSLSP	CBL_PTK	0.1111
p.A148T	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	NGILSYSLSP	CBL_PTK	0.1111
p.S175L	DO222578	MELA	ICGC	NGILSYSLSP	CBL_PTK	0.0556
p.R170C	DO227569	PBCA	ICGC	NGILSYSLSP	CBL_PTK	0.1944
p.G157R	DO218874	SKCA	ICGC	NGILSYSLSP	CBL_PTK	0.6457
p.L159P	SIDM00449	B-Lymphoblastic Leukemia	GDSC	NGILSYSLSP	CBL_PTK	0.6471
p.H168R	SIDM00217	Colorectal Carcinoma	GDSC	NGILSYSLSP	CBL_PTK	0.25
p.H168R	ACH-000999	Colon/Colorectal Cancer	CCLE	NGILSYSLSP	CBL_PTK	0.25
p.H168R	SNU-1040	large_intestine	COSMIC	NGILSYSLSP	CBL_PTK	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H158	Protocadherin alpha-C1	CBL_PTK	156:165	NGILSYSLSP	CBL	0.5532	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons