DegronMD - A8MU93(C17orf100)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E28D	TCGA-AP-A1E0	UCEC	TCGA	VETSS	DEG_SPOP_SBC_1	27:31	Mutation altering degron motif	0.5647
p.E28D	DO43154	UCEC	ICGC	VETSS	DEG_SPOP_SBC_1	27:31	Mutation altering degron motif	0.5647
p.E72D	DO227593	BRCA	ICGC	VESSS	DEG_SPOP_SBC_1	71:75	Mutation altering degron motif	0.5647
p.I63T	DO8264	COAD	ICGC	VESSS	DEG_SPOP_SBC_1	71:75	Mutation rewiring degron network	0.1111
p.S48R	DO233267	GACA	ICGC	VETSS	DEG_SPOP_SBC_1	34:38	Mutation blocking phosphorylation signal	0.5
p.R62H	DO228952	LICA	ICGC	VESSS	DEG_SPOP_SBC_1	71:75	Mutation rewiring degron network	0.0833
p.S31F	DO222423	MELA	ICGC	VETSS	DEG_SPOP_SBC_1	27:31	Mutation altering degron motif	0.7982
p.S31F	DO37425	SKCM	ICGC	VETSS	DEG_SPOP_SBC_1	27:31	Mutation altering degron motif	0.7982
p.R40Q	SIDM00447	B-Lymphoblastic Leukemia	GDSC	VETSS	DEG_SPOP_SBC_1	27:31	Mutation rewiring degron network	0.0833
p.R40Q	SIDM00447	B-Lymphoblastic Leukemia	GDSC	VETSS	DEG_SPOP_SBC_1	34:38	Mutation rewiring degron network	0.2778
p.R40Q	ACH-000960	Leukemia	CCLE	VETSS	DEG_SPOP_SBC_1	27:31	Mutation rewiring degron network	0.0833
p.R40Q	ACH-000960	Leukemia	CCLE	VETSS	DEG_SPOP_SBC_1	34:38	Mutation rewiring degron network	0.2778
p.T17S	ACH-000280	Ovarian Cancer	CCLE	VETSS	DEG_SPOP_SBC_1	27:31	Mutation blocking phosphorylation signal	0.5
p.T43P	ACH-000895	Colon/Colorectal Cancer	CCLE	VETSS	DEG_SPOP_SBC_1	34:38	Mutation rewiring degron network	0.1944

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons