DegronMD

Uniprot ID: A8MU93

Source protein: Uncharacterized protein C17orf100

Source gene: C17orf100

Class: DEG_SPOP_SBC_1

Location: 27:31

E3 ligase: SPOP

DEGRON score: 0.9983

ASA_SCORE: 72.24

COIL: 0.7208

CONS_SCORE: 0.9835

DSS_SCORE: 0.6221

HELIX: 0.0482

FCONS_SCORE: 1.3137

RIG_SCORE: 0.6957

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E28D	TCGA-AP-A1E0	UCEC	TCGA	VETSS	DEG_SPOP_SBC_1	0.5647
p.E28D	DO43154	UCEC	ICGC	VETSS	DEG_SPOP_SBC_1	0.5647
p.S31F	DO222423	MELA	ICGC	VETSS	DEG_SPOP_SBC_1	0.7982
p.S31F	DO37425	SKCM	ICGC	VETSS	DEG_SPOP_SBC_1	0.7982
p.R40Q	SIDM00447	B-Lymphoblastic Leukemia	GDSC	VETSS	DEG_SPOP_SBC_1	0.0833
p.R40Q	ACH-000960	Leukemia	CCLE	VETSS	DEG_SPOP_SBC_1	0.0833
p.T17S	ACH-000280	Ovarian Cancer	CCLE	VETSS	DEG_SPOP_SBC_1	0.5

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35658	Nuclear pore complex protein Nup214	DEG_SPOP_SBC_1	1609:1613	VETSS	SPOP	0.9382	More...
Q2M3C7	A-kinase anchor protein SPHKAP	DEG_SPOP_SBC_1	477:481	VETSS	SPOP	0.9644	More...
Q86UP2	Kinectin	DEG_SPOP_SBC_1	105:109	VETSS	SPOP	0.9538	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	2459:2463	VETSS	SPOP	0.921	More...
Q7Z3V4	Ubiquitin-protein ligase E3B	DEG_SPOP_SBC_1	671:675	VETSS	SPOP	0.902	More...
Q5VYV7	Protein SLX4IP	DEG_SPOP_SBC_1	190:194	VETSS	SPOP	0.9987	More...
A8MU93	Uncharacterized protein C17orf100	DEG_SPOP_SBC_1	27:31	VETSS	SPOP	0.9983	More...
A8MU93	Uncharacterized protein C17orf100	DEG_SPOP_SBC_1	34:38	VETSS	SPOP	0.9254	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons