DegronMD

Uniprot ID: Q2M3C7

Source protein: A-kinase anchor protein SPHKAP

Source gene: SPHKAP

Class: DEG_SPOP_SBC_1

Location: 477:481

E3 ligase: SPOP

DEGRON score: 0.9644

ASA_SCORE: 74.54

COIL: 0.7624

CONS_SCORE: 0.3921

DSS_SCORE: 0.5105

HELIX: 0.133

FCONS_SCORE: 0.8634

RIG_SCORE: 0.7412

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I467F	TCGA-49-AAR0	LUAD	TCGA	VETSS	DEG_SPOP_SBC_1	0.0556
p.I467F	DO218917	LUAD	ICGC	VETSS	DEG_SPOP_SBC_1	0.0556
p.T479P	TCGA-78-7155	LUAD	TCGA	VETSS	DEG_SPOP_SBC_1	0.7031
p.T479P	DO23590	LUAD	ICGC	VETSS	DEG_SPOP_SBC_1	0.7031
p.S469Y	TCGA-98-7454	LUSC	TCGA	VETSS	DEG_SPOP_SBC_1	0.1111
p.S469Y	DO26460	LUSC	ICGC	VETSS	DEG_SPOP_SBC_1	0.1111
p.S489R	TCGA-AA-3846	COAD	TCGA	VETSS	DEG_SPOP_SBC_1	0.1111
p.S489R	DO8682	COAD	ICGC	VETSS	DEG_SPOP_SBC_1	0.1111
p.L483F	TCGA-D9-A6EA	SKCM	TCGA	VETSS	DEG_SPOP_SBC_1	0.2778
p.L483F	DO222550	MELA	ICGC	VETSS	DEG_SPOP_SBC_1	0.2778
p.L483F	DO50290	SKCM	ICGC	VETSS	DEG_SPOP_SBC_1	0.2778
p.E478K	TCGA-EE-A2GM	SKCM	TCGA	VETSS	DEG_SPOP_SBC_1	0.591
p.E478K	DO37555	SKCM	ICGC	VETSS	DEG_SPOP_SBC_1	0.591
p.T479I	TCGA-ER-A19G	SKCM	TCGA	VETSS	DEG_SPOP_SBC_1	0.7078
p.T479I	DO47284	SKCM	ICGC	VETSS	DEG_SPOP_SBC_1	0.7078
p.V477A	TCGA-FI-A2D5	UCEC	TCGA	VETSS	DEG_SPOP_SBC_1	0.5825
p.V477A	DO41331	UCEC	ICGC	VETSS	DEG_SPOP_SBC_1	0.5825
p.S468F	TCGA-QB-AA9O	SKCM	TCGA	VETSS	DEG_SPOP_SBC_1	0.0833
p.S468F	DO51267	SKCM	ICGC	VETSS	DEG_SPOP_SBC_1	0.0833
p.G485R	TCGA-W3-AA1R	SKCM	TCGA	VETSS	DEG_SPOP_SBC_1	0.2222
p.G485R	DO51275	SKCM	ICGC	VETSS	DEG_SPOP_SBC_1	0.2222
p.M473I	DO222837	MELA	ICGC	VETSS	DEG_SPOP_SBC_1	0.2222
p.G485E	DO222843	MELA	ICGC	VETSS	DEG_SPOP_SBC_1	0.2222
p.E474K	DO218900	SKCA	ICGC	VETSS	DEG_SPOP_SBC_1	0.25
p.S484F	SIDM00007	Other Solid Cancers	GDSC	VETSS	DEG_SPOP_SBC_1	0.25
p.S484F	ACH-001550	Skin Cancer	CCLE	VETSS	DEG_SPOP_SBC_1	0.25
p.S484F	MCC13	skin	COSMIC	VETSS	DEG_SPOP_SBC_1	0.25
p.V477F	SIDM00507	Other Solid Cancers	GDSC	VETSS	DEG_SPOP_SBC_1	0.7068
p.V477F	ACH-001490	Lung Cancer	CCLE	VETSS	DEG_SPOP_SBC_1	0.7068
p.V477F	COR-L321	NS	COSMIC	VETSS	DEG_SPOP_SBC_1	0.7068
p.W470G	SIDM00965	Small Cell Lung Carcinoma	GDSC	VETSS	DEG_SPOP_SBC_1	0.1389
p.W470G	ACH-000800	Lung Cancer	CCLE	VETSS	DEG_SPOP_SBC_1	0.1389
p.W470G	NCI-H446	lung	COSMIC	VETSS	DEG_SPOP_SBC_1	0.1389
p.V477I	SIDM00150	Colorectal Carcinoma	GDSC	VETSS	DEG_SPOP_SBC_1	0.7076
p.V477I	ACH-000969	Colon/Colorectal Cancer	CCLE	VETSS	DEG_SPOP_SBC_1	0.7076
p.V477I	KM12	large_intestine	COSMIC	VETSS	DEG_SPOP_SBC_1	0.7076

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35658	Nuclear pore complex protein Nup214	DEG_SPOP_SBC_1	1609:1613	VETSS	SPOP	0.9382	More...
Q2M3C7	A-kinase anchor protein SPHKAP	DEG_SPOP_SBC_1	477:481	VETSS	SPOP	0.9644	More...
Q86UP2	Kinectin	DEG_SPOP_SBC_1	105:109	VETSS	SPOP	0.9538	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	2459:2463	VETSS	SPOP	0.921	More...
Q7Z3V4	Ubiquitin-protein ligase E3B	DEG_SPOP_SBC_1	671:675	VETSS	SPOP	0.902	More...
Q5VYV7	Protein SLX4IP	DEG_SPOP_SBC_1	190:194	VETSS	SPOP	0.9987	More...
A8MU93	Uncharacterized protein C17orf100	DEG_SPOP_SBC_1	27:31	VETSS	SPOP	0.9983	More...
A8MU93	Uncharacterized protein C17orf100	DEG_SPOP_SBC_1	34:38	VETSS	SPOP	0.9254	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VETSS

Degron related mutations and impact score

Drug responses associated with SPHKAP mutations

All proteins holding degron of VETSS