DegronMD

Uniprot ID: Q5VYV7

Source protein: Protein SLX4IP

Source gene: SLX4IP

Class: DEG_SPOP_SBC_1

Location: 190:194

E3 ligase: SPOP

DEGRON score: 0.9987

ASA_SCORE: 77.86

COIL: 0.7878

CONS_SCORE: 0.3969

DSS_SCORE: 0.5877

HELIX: 0.1168

FCONS_SCORE: 1.141

RIG_SCORE: 0.6977

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T180R	TCGA-60-2721	LUSC	TCGA	VETSS	DEG_SPOP_SBC_1	0.0556
p.T180R	TCGA-90-A4EE	LUSC	TCGA	VETSS	DEG_SPOP_SBC_1	0.0556
p.T180R	DO26447	LUSC	ICGC	VETSS	DEG_SPOP_SBC_1	0.0556
p.T180R	DO45513	LUSC	ICGC	VETSS	DEG_SPOP_SBC_1	0.0556
p.T180R	SIDM01039	Other Solid Cancers	GDSC	VETSS	DEG_SPOP_SBC_1	0.0556
p.T180R	ACH-001529	Endometrial/Uterine Cancer	CCLE	VETSS	DEG_SPOP_SBC_1	0.0556
p.T180R	JAR	placenta	COSMIC	VETSS	DEG_SPOP_SBC_1	0.0556
p.S183L	TCGA-A5-A0G2	UCEC	TCGA	VETSS	DEG_SPOP_SBC_1	0.5833
p.S183L	DO41235	UCEC	ICGC	VETSS	DEG_SPOP_SBC_1	0.5833
p.A199V	TCGA-GF-A6C9	SKCM	TCGA	VETSS	DEG_SPOP_SBC_1	0.1944
p.A199V	DO51254	SKCM	ICGC	VETSS	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35658	Nuclear pore complex protein Nup214	DEG_SPOP_SBC_1	1609:1613	VETSS	SPOP	0.9382	More...
Q2M3C7	A-kinase anchor protein SPHKAP	DEG_SPOP_SBC_1	477:481	VETSS	SPOP	0.9644	More...
Q86UP2	Kinectin	DEG_SPOP_SBC_1	105:109	VETSS	SPOP	0.9538	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	2459:2463	VETSS	SPOP	0.921	More...
Q7Z3V4	Ubiquitin-protein ligase E3B	DEG_SPOP_SBC_1	671:675	VETSS	SPOP	0.902	More...
Q5VYV7	Protein SLX4IP	DEG_SPOP_SBC_1	190:194	VETSS	SPOP	0.9987	More...
A8MU93	Uncharacterized protein C17orf100	DEG_SPOP_SBC_1	27:31	VETSS	SPOP	0.9983	More...
A8MU93	Uncharacterized protein C17orf100	DEG_SPOP_SBC_1	34:38	VETSS	SPOP	0.9254	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons