DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SPOP_SBC_1

Location: 2459:2463

E3 ligase: SPOP

DEGRON score: 0.921

ASA_SCORE: 93.76

COIL: 0.8284

CONS_SCORE: 0

DSS_SCORE: 0.3561

HELIX: 0.051

FCONS_SCORE: 0

RIG_SCORE: 0.8069

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P2471L	TCGA-BF-AAP7	SKCM	TCGA	VETSS	DEG_SPOP_SBC_1	0.1111
p.P2471L	DO219472	SKCM	ICGC	VETSS	DEG_SPOP_SBC_1	0.1111
p.A2464T	TCGA-D5-6928	COAD	TCGA	VETSS	DEG_SPOP_SBC_1	0.3056
p.A2464T	DO7776	COAD	ICGC	VETSS	DEG_SPOP_SBC_1	0.3056
p.T2461K	TCGA-EM-A2CR	THCA	TCGA	VETSS	DEG_SPOP_SBC_1	0.8417
p.T2461K	DO40729	THCA	ICGC	VETSS	DEG_SPOP_SBC_1	0.8417
p.S2463W	TCGA-G2-A3IE	BLCA	TCGA	VETSS	DEG_SPOP_SBC_1	0.7874
p.S2463W	DO767	BLCA	ICGC	VETSS	DEG_SPOP_SBC_1	0.7874
p.S2469Y	TCGA-MN-A4N1	LUAD	TCGA	VETSS	DEG_SPOP_SBC_1	0.1667
p.S2469Y	DO45328	LUAD	ICGC	VETSS	DEG_SPOP_SBC_1	0.1667
p.S2463L	DO227870	COCA	ICGC	VETSS	DEG_SPOP_SBC_1	0.7667
p.S2463L	SIDM00967	Ovarian Carcinoma	GDSC	VETSS	DEG_SPOP_SBC_1	0.7667
p.S2463L	SIDM01133	Other Solid Cancers	GDSC	VETSS	DEG_SPOP_SBC_1	0.7667
p.S2463L	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	VETSS	DEG_SPOP_SBC_1	0.7667
p.S2463L	SIDM00720	Mesothelioma	GDSC	VETSS	DEG_SPOP_SBC_1	0.7667
p.S2463L	SIDM01409	Bladder Carcinoma	GDSC	VETSS	DEG_SPOP_SBC_1	0.7667
p.A2464D	DO229035	LICA	ICGC	VETSS	DEG_SPOP_SBC_1	0.3056
p.P2471T	DO229009	LICA	ICGC	VETSS	DEG_SPOP_SBC_1	0.1111
p.V2459D	DO228011	SKCA	ICGC	VETSS	DEG_SPOP_SBC_1	0.7785
p.T2461R	SIDM00513	Non-Small Cell Lung Carcinoma	GDSC	VETSS	DEG_SPOP_SBC_1	0.8987
p.T2461R	ACH-000046	Kidney Cancer	CCLE	VETSS	DEG_SPOP_SBC_1	0.8987
p.T2461R	ACH-000161	Lung Cancer	CCLE	VETSS	DEG_SPOP_SBC_1	0.8987
p.T2461R	COR-L105	lung	COSMIC	VETSS	DEG_SPOP_SBC_1	0.8987
p.I2455V	SIDM01078	Small Cell Lung Carcinoma	GDSC	VETSS	DEG_SPOP_SBC_1	0.2222
p.I2455V	ACH-000790	Lung Cancer	CCLE	VETSS	DEG_SPOP_SBC_1	0.2222
p.I2455V	SHP-77	lung	COSMIC	VETSS	DEG_SPOP_SBC_1	0.2222
p.L2465I	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	VETSS	DEG_SPOP_SBC_1	0.2778
p.L2465I	H513	pleura	COSMIC	VETSS	DEG_SPOP_SBC_1	0.2778
p.P2458S	SIDM00221	Melanoma	GDSC	VETSS	DEG_SPOP_SBC_1	0.3056
p.P2458S	ACH-002388	Skin Cancer	CCLE	VETSS	DEG_SPOP_SBC_1	0.3056
p.H2457Q	SIDM00254	Neuroblastoma	GDSC	VETSS	DEG_SPOP_SBC_1	0.2778
p.H2457Q	ACH-002283	Neuroblastoma	CCLE	VETSS	DEG_SPOP_SBC_1	0.2778
p.H2457Q	NB5	autonomic_ganglia	COSMIC	VETSS	DEG_SPOP_SBC_1	0.2778
p.T2454K	SIDM00930	Osteosarcoma	GDSC	VETSS	DEG_SPOP_SBC_1	0.6389
p.T2454K	ACH-001715	Bone Cancer	CCLE	VETSS	DEG_SPOP_SBC_1	0.6389
p.T2454K	CAL-72	bone	COSMIC	VETSS	DEG_SPOP_SBC_1	0.6389
p.P2458T	SIDM00750	Non-Small Cell Lung Carcinoma	GDSC	VETSS	DEG_SPOP_SBC_1	0.3056
p.P2458T	ACH-000869	Lung Cancer	CCLE	VETSS	DEG_SPOP_SBC_1	0.3056
p.P2458T	NCI-H1568	lung	COSMIC	VETSS	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35658	Nuclear pore complex protein Nup214	DEG_SPOP_SBC_1	1609:1613	VETSS	SPOP	0.9382	More...
Q2M3C7	A-kinase anchor protein SPHKAP	DEG_SPOP_SBC_1	477:481	VETSS	SPOP	0.9644	More...
Q86UP2	Kinectin	DEG_SPOP_SBC_1	105:109	VETSS	SPOP	0.9538	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	2459:2463	VETSS	SPOP	0.921	More...
Q7Z3V4	Ubiquitin-protein ligase E3B	DEG_SPOP_SBC_1	671:675	VETSS	SPOP	0.902	More...
Q5VYV7	Protein SLX4IP	DEG_SPOP_SBC_1	190:194	VETSS	SPOP	0.9987	More...
A8MU93	Uncharacterized protein C17orf100	DEG_SPOP_SBC_1	27:31	VETSS	SPOP	0.9983	More...
A8MU93	Uncharacterized protein C17orf100	DEG_SPOP_SBC_1	34:38	VETSS	SPOP	0.9254	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VETSS

Degron related mutations and impact score

Drug responses associated with MUC16 mutations

All proteins holding degron of VETSS