DegronMD - Q5VYV7(SLX4IP)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A122V	TCGA-55-7994	LUAD	TCGA	LCVFPD	LIG_APCC_ABBA_1	107:112	Mutation rewiring degron network	0.0556
p.A122V	DO45311	LUAD	ICGC	LCVFPD	LIG_APCC_ABBA_1	107:112	Mutation rewiring degron network	0.0556
p.K160T	TCGA-56-8628	LUSC	TCGA	RRNALKEIV	DEG_APCC_DBOX_1	162:170	Mutation rewiring degron network	0.2778
p.K160T	DO45433	LUSC	ICGC	RRNALKEIV	DEG_APCC_DBOX_1	162:170	Mutation rewiring degron network	0.2778
p.T180R	TCGA-60-2721	LUSC	TCGA	RRNALKEIV	DEG_APCC_DBOX_1	162:170	Mutation rewiring degron network	0.0556
p.T180R	TCGA-60-2721	LUSC	TCGA	VETSS	DEG_SPOP_SBC_1	190:194	Mutation rewiring degron network	0.0556
p.T180R	TCGA-90-A4EE	LUSC	TCGA	RRNALKEIV	DEG_APCC_DBOX_1	162:170	Mutation rewiring degron network	0.0556
p.T180R	TCGA-90-A4EE	LUSC	TCGA	VETSS	DEG_SPOP_SBC_1	190:194	Mutation rewiring degron network	0.0556
p.T180R	DO26447	LUSC	ICGC	RRNALKEIV	DEG_APCC_DBOX_1	162:170	Mutation rewiring degron network	0.0556
p.T180R	DO26447	LUSC	ICGC	VETSS	DEG_SPOP_SBC_1	190:194	Mutation rewiring degron network	0.0556
p.T180R	DO45513	LUSC	ICGC	RRNALKEIV	DEG_APCC_DBOX_1	162:170	Mutation rewiring degron network	0.0556
p.T180R	DO45513	LUSC	ICGC	VETSS	DEG_SPOP_SBC_1	190:194	Mutation rewiring degron network	0.0556
p.T180R	SIDM01039	Other Solid Cancers	GDSC	RRNALKEIV	DEG_APCC_DBOX_1	162:170	Mutation rewiring degron network	0.0556
p.T180R	SIDM01039	Other Solid Cancers	GDSC	VETSS	DEG_SPOP_SBC_1	190:194	Mutation rewiring degron network	0.0556
p.T180R	ACH-001529	Endometrial/Uterine Cancer	CCLE	RRNALKEIV	DEG_APCC_DBOX_1	162:170	Mutation rewiring degron network	0.0556
p.T180R	ACH-001529	Endometrial/Uterine Cancer	CCLE	VETSS	DEG_SPOP_SBC_1	190:194	Mutation rewiring degron network	0.0556
p.T180R	JAR	placenta	COSMIC	RRNALKEIV	DEG_APCC_DBOX_1	162:170	Mutation rewiring degron network	0.0556
p.T180R	JAR	placenta	COSMIC	VETSS	DEG_SPOP_SBC_1	190:194	Mutation rewiring degron network	0.0556
p.S183L	TCGA-A5-A0G2	UCEC	TCGA	VETSS	DEG_SPOP_SBC_1	190:194	Mutation blocking phosphorylation signal	0.5833
p.S183L	DO41235	UCEC	ICGC	VETSS	DEG_SPOP_SBC_1	190:194	Mutation blocking phosphorylation signal	0.5833
p.K171T	TCGA-AK-3430	KIRC	TCGA	RRNALKEIV	DEG_APCC_DBOX_1	162:170	Mutation rewiring degron network	0.3056
p.K171T	DO17898	KIRC	ICGC	RRNALKEIV	DEG_APCC_DBOX_1	162:170	Mutation rewiring degron network	0.3056
p.E152D	TCGA-DK-AA6X	BLCA	TCGA	RRNALKEIV	DEG_APCC_DBOX_1	162:170	Mutation rewiring degron network	0.0556
p.E152D	DO51873	BLCA	ICGC	RRNALKEIV	DEG_APCC_DBOX_1	162:170	Mutation rewiring degron network	0.0556
p.L107F	TCGA-EO-A22X	UCEC	TCGA	LCVFPD	LIG_APCC_ABBA_1	107:112	Mutation altering degron motif	0.587
p.L107F	DO43907	UCEC	ICGC	LCVFPD	LIG_APCC_ABBA_1	107:112	Mutation altering degron motif	0.587
p.T175A	TCGA-FT-A61P	BLCA	TCGA	RRNALKEIV	DEG_APCC_DBOX_1	162:170	Mutation rewiring degron network	0.1944
p.T175A	DO44035	BLCA	ICGC	RRNALKEIV	DEG_APCC_DBOX_1	162:170	Mutation rewiring degron network	0.1944
p.A199V	TCGA-GF-A6C9	SKCM	TCGA	VETSS	DEG_SPOP_SBC_1	190:194	Mutation rewiring degron network	0.1944
p.A199V	DO51254	SKCM	ICGC	VETSS	DEG_SPOP_SBC_1	190:194	Mutation rewiring degron network	0.1944
p.R100G	TCGA-L5-A88S	ESCA	TCGA	LCVFPD	LIG_APCC_ABBA_1	107:112	Mutation rewiring degron network	0.1389
p.S101R	DO8858	COAD	ICGC	LCVFPD	LIG_APCC_ABBA_1	107:112	Mutation rewiring degron network	0.1667
p.F114C	DO9876	COAD	ICGC	LCVFPD	LIG_APCC_ABBA_1	107:112	Mutation rewiring degron network	0.2778
p.R97C	DO229016	COCA	ICGC	LCVFPD	LIG_APCC_ABBA_1	107:112	Mutation rewiring degron network	0.0556
p.R97C	DO229047	LICA	ICGC	LCVFPD	LIG_APCC_ABBA_1	107:112	Mutation rewiring degron network	0.0556
p.R97C	SIDM00496	Thyroid Gland Carcinoma	GDSC	LCVFPD	LIG_APCC_ABBA_1	107:112	Mutation rewiring degron network	0.0556
p.R97C	SIDM01055	Glioblastoma	GDSC	LCVFPD	LIG_APCC_ABBA_1	107:112	Mutation rewiring degron network	0.0556
p.R97C	SIDM00354	Squamous Cell Lung Carcinoma	GDSC	LCVFPD	LIG_APCC_ABBA_1	107:112	Mutation rewiring degron network	0.0556
p.R97C	SIDM00282	Colorectal Carcinoma	GDSC	LCVFPD	LIG_APCC_ABBA_1	107:112	Mutation rewiring degron network	0.0556
p.R97C	SIDM00585	Hepatocellular Carcinoma	GDSC	LCVFPD	LIG_APCC_ABBA_1	107:112	Mutation rewiring degron network	0.0556
p.R97C	SIDM00292	Small Cell Lung Carcinoma	GDSC	LCVFPD	LIG_APCC_ABBA_1	107:112	Mutation rewiring degron network	0.0556
p.R97C	SIDM00237	Non-Small Cell Lung Carcinoma	GDSC	LCVFPD	LIG_APCC_ABBA_1	107:112	Mutation rewiring degron network	0.0556
p.R97C	SIDM00498	Colorectal Carcinoma	GDSC	LCVFPD	LIG_APCC_ABBA_1	107:112	Mutation rewiring degron network	0.0556
p.R97C	SIDM00298	Squamous Cell Lung Carcinoma	GDSC	LCVFPD	LIG_APCC_ABBA_1	107:112	Mutation rewiring degron network	0.0556
p.R97C	SIDM00567	Other Solid Cancers	GDSC	LCVFPD	LIG_APCC_ABBA_1	107:112	Mutation rewiring degron network	0.0556
p.R97C	SIDM01653	Non-Cancerous	GDSC	LCVFPD	LIG_APCC_ABBA_1	107:112	Mutation rewiring degron network	0.0556
p.R97C	SIDM00283	B-Cell Non-Hodgkin's Lymphoma	GDSC	LCVFPD	LIG_APCC_ABBA_1	107:112	Mutation rewiring degron network	0.0556
p.R97C	SIDM00207	Glioblastoma	GDSC	LCVFPD	LIG_APCC_ABBA_1	107:112	Mutation rewiring degron network	0.0556
p.R97C	SIDM00655	Other Solid Cancers	GDSC	LCVFPD	LIG_APCC_ABBA_1	107:112	Mutation rewiring degron network	0.0556
p.R97C	SIDM00324	Neuroblastoma	GDSC	LCVFPD	LIG_APCC_ABBA_1	107:112	Mutation rewiring degron network	0.0556
p.R97C	SIDM00448	B-Cell Non-Hodgkin's Lymphoma	GDSC	LCVFPD	LIG_APCC_ABBA_1	107:112	Mutation rewiring degron network	0.0556
p.R97C	SIDM01449	Pancreatic Carcinoma	GDSC	LCVFPD	LIG_APCC_ABBA_1	107:112	Mutation rewiring degron network	0.0556
p.R97C	SIDM01460	Glioma	GDSC	LCVFPD	LIG_APCC_ABBA_1	107:112	Mutation rewiring degron network	0.0556
p.R97C	SIDM01660	Kidney Carcinoma	GDSC	LCVFPD	LIG_APCC_ABBA_1	107:112	Mutation rewiring degron network	0.0556
p.R97C	SIDM01464	Pancreatic Carcinoma	GDSC	LCVFPD	LIG_APCC_ABBA_1	107:112	Mutation rewiring degron network	0.0556
p.R97C	SIDM01347	Ovarian Carcinoma	GDSC	LCVFPD	LIG_APCC_ABBA_1	107:112	Mutation rewiring degron network	0.0556
p.R97C	SIDM01435	Hepatocellular Carcinoma	GDSC	LCVFPD	LIG_APCC_ABBA_1	107:112	Mutation rewiring degron network	0.0556
p.R97C	SIDM01446	Glioblastoma	GDSC	LCVFPD	LIG_APCC_ABBA_1	107:112	Mutation rewiring degron network	0.0556
p.R97C	SIDM01473	Plasma Cell Myeloma	GDSC	LCVFPD	LIG_APCC_ABBA_1	107:112	Mutation rewiring degron network	0.0556
p.C98F	DO228976	LICA	ICGC	LCVFPD	LIG_APCC_ABBA_1	107:112	Mutation rewiring degron network	0.0833
p.V179F	DO229018	LICA	ICGC	RRNALKEIV	DEG_APCC_DBOX_1	162:170	Mutation rewiring degron network	0.0833
p.V179F	DO229024	LICA	ICGC	RRNALKEIV	DEG_APCC_DBOX_1	162:170	Mutation rewiring degron network	0.0833
p.S178N	DO229237	LMS	ICGC	RRNALKEIV	DEG_APCC_DBOX_1	162:170	Mutation rewiring degron network	0.1111
p.K176E	DO230993	LUSC	ICGC	RRNALKEIV	DEG_APCC_DBOX_1	162:170	Mutation substituting flanking lysine	0.2778
p.P111S	DO222843	MELA	ICGC	LCVFPD	LIG_APCC_ABBA_1	107:112	Mutation altering degron motif	0.5641
p.S153R	DO47124	RECA	ICGC	RRNALKEIV	DEG_APCC_DBOX_1	162:170	Mutation rewiring degron network	0.0833
p.L121I	SIDM01950	Colorectal Carcinoma	GDSC	LCVFPD	LIG_APCC_ABBA_1	107:112	Mutation rewiring degron network	0.0833
p.A105V	SIDM00698	Small Cell Lung Carcinoma	GDSC	LCVFPD	LIG_APCC_ABBA_1	107:112	Mutation rewiring degron network	0.2778
p.A105V	SIDM00649	Non-Small Cell Lung Carcinoma	GDSC	LCVFPD	LIG_APCC_ABBA_1	107:112	Mutation rewiring degron network	0.2778
p.A105V	SIDM00386	Ewing's Sarcoma	GDSC	LCVFPD	LIG_APCC_ABBA_1	107:112	Mutation rewiring degron network	0.2778
p.A105V	SIDM00812	Colorectal Carcinoma	GDSC	LCVFPD	LIG_APCC_ABBA_1	107:112	Mutation rewiring degron network	0.2778
p.A105V	SIDM00013	Melanoma	GDSC	LCVFPD	LIG_APCC_ABBA_1	107:112	Mutation rewiring degron network	0.2778
p.A105V	SIDM01073	Other Blood Cancers	GDSC	LCVFPD	LIG_APCC_ABBA_1	107:112	Mutation rewiring degron network	0.2778
p.A105V	SIDM01003	T-Lymphoblastic Leukemia	GDSC	LCVFPD	LIG_APCC_ABBA_1	107:112	Mutation rewiring degron network	0.2778
p.A105V	SIDM00049	Colorectal Carcinoma	GDSC	LCVFPD	LIG_APCC_ABBA_1	107:112	Mutation rewiring degron network	0.2778
p.A105V	SIDM00685	Glioblastoma	GDSC	LCVFPD	LIG_APCC_ABBA_1	107:112	Mutation rewiring degron network	0.2778
p.A105V	SIDM00387	Neuroblastoma	GDSC	LCVFPD	LIG_APCC_ABBA_1	107:112	Mutation rewiring degron network	0.2778
p.A105V	SIDM01491	Colorectal Carcinoma	GDSC	LCVFPD	LIG_APCC_ABBA_1	107:112	Mutation rewiring degron network	0.2778
p.E106D	SIDM00850	Gastric Carcinoma	GDSC	LCVFPD	LIG_APCC_ABBA_1	107:112	Mutation rewiring degron network	0.3056
p.E106D	AGS	stomach	COSMIC	LCVFPD	LIG_APCC_ABBA_1	107:112	Mutation rewiring degron network	0.3056
p.E174K	ACH-000975	Lung Cancer	CCLE	RRNALKEIV	DEG_APCC_DBOX_1	162:170	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SLX4IP

UniProt ID: Q5VYV7

Entrez ID: 128710

Protein name: Protein SLX4IP (SLX4-interacting protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SLX4IP in