DegronMD

Uniprot ID: Q5VYV7

Source protein: Protein SLX4IP

Source gene: SLX4IP

Class: DEG_APCC_DBOX_1

Location: 162:170

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8661

ASA_SCORE: 74.3333

COIL: 0.0804

CONS_SCORE: 0.631

DSS_SCORE: 0.4693

HELIX: 0.9161

FCONS_SCORE: 1.4553

RIG_SCORE: 0.7755

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K160T	TCGA-56-8628	LUSC	TCGA	RRNALKEIV	DEG_APCC_DBOX_1	0.2778
p.K160T	DO45433	LUSC	ICGC	RRNALKEIV	DEG_APCC_DBOX_1	0.2778
p.T180R	TCGA-60-2721	LUSC	TCGA	RRNALKEIV	DEG_APCC_DBOX_1	0.0556
p.T180R	TCGA-90-A4EE	LUSC	TCGA	RRNALKEIV	DEG_APCC_DBOX_1	0.0556
p.T180R	DO26447	LUSC	ICGC	RRNALKEIV	DEG_APCC_DBOX_1	0.0556
p.T180R	DO45513	LUSC	ICGC	RRNALKEIV	DEG_APCC_DBOX_1	0.0556
p.T180R	SIDM01039	Other Solid Cancers	GDSC	RRNALKEIV	DEG_APCC_DBOX_1	0.0556
p.T180R	ACH-001529	Endometrial/Uterine Cancer	CCLE	RRNALKEIV	DEG_APCC_DBOX_1	0.0556
p.T180R	JAR	placenta	COSMIC	RRNALKEIV	DEG_APCC_DBOX_1	0.0556
p.K171T	TCGA-AK-3430	KIRC	TCGA	RRNALKEIV	DEG_APCC_DBOX_1	0.3056
p.K171T	DO17898	KIRC	ICGC	RRNALKEIV	DEG_APCC_DBOX_1	0.3056
p.E152D	TCGA-DK-AA6X	BLCA	TCGA	RRNALKEIV	DEG_APCC_DBOX_1	0.0556
p.E152D	DO51873	BLCA	ICGC	RRNALKEIV	DEG_APCC_DBOX_1	0.0556
p.T175A	TCGA-FT-A61P	BLCA	TCGA	RRNALKEIV	DEG_APCC_DBOX_1	0.1944
p.T175A	DO44035	BLCA	ICGC	RRNALKEIV	DEG_APCC_DBOX_1	0.1944
p.V179F	DO229018	LICA	ICGC	RRNALKEIV	DEG_APCC_DBOX_1	0.0833
p.V179F	DO229024	LICA	ICGC	RRNALKEIV	DEG_APCC_DBOX_1	0.0833
p.S178N	DO229237	LMS	ICGC	RRNALKEIV	DEG_APCC_DBOX_1	0.1111
p.K176E	DO230993	LUSC	ICGC	RRNALKEIV	DEG_APCC_DBOX_1	0.2778
p.S153R	DO47124	RECA	ICGC	RRNALKEIV	DEG_APCC_DBOX_1	0.0833
p.E174K	ACH-000975	Lung Cancer	CCLE	RRNALKEIV	DEG_APCC_DBOX_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5VYV7	Protein SLX4IP	DEG_APCC_DBOX_1	162:170	RRNALKEIV	APC,CDC20,FZR1	0.8661	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons