DegronMD

Uniprot ID: Q5VYV7

Source protein: Protein SLX4IP

Source gene: SLX4IP

Class: LIG_APCC_ABBA_1

Location: 107:112

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6465

ASA_SCORE: 47.4

COIL: 0.4453

CONS_SCORE: 0.8275

DSS_SCORE: 0.0119

HELIX: 0.0198

FCONS_SCORE: 1.24

RIG_SCORE: 0.9431

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A122V	TCGA-55-7994	LUAD	TCGA	LCVFPD	LIG_APCC_ABBA_1	0.0556
p.A122V	DO45311	LUAD	ICGC	LCVFPD	LIG_APCC_ABBA_1	0.0556
p.L107F	TCGA-EO-A22X	UCEC	TCGA	LCVFPD	LIG_APCC_ABBA_1	0.587
p.L107F	DO43907	UCEC	ICGC	LCVFPD	LIG_APCC_ABBA_1	0.587
p.R100G	TCGA-L5-A88S	ESCA	TCGA	LCVFPD	LIG_APCC_ABBA_1	0.1389
p.S101R	DO8858	COAD	ICGC	LCVFPD	LIG_APCC_ABBA_1	0.1667
p.F114C	DO9876	COAD	ICGC	LCVFPD	LIG_APCC_ABBA_1	0.2778
p.R97C	DO229016	COCA	ICGC	LCVFPD	LIG_APCC_ABBA_1	0.0556
p.R97C	DO229047	LICA	ICGC	LCVFPD	LIG_APCC_ABBA_1	0.0556
p.R97C	SIDM00496	Thyroid Gland Carcinoma	GDSC	LCVFPD	LIG_APCC_ABBA_1	0.0556
p.R97C	SIDM01055	Glioblastoma	GDSC	LCVFPD	LIG_APCC_ABBA_1	0.0556
p.R97C	SIDM00354	Squamous Cell Lung Carcinoma	GDSC	LCVFPD	LIG_APCC_ABBA_1	0.0556
p.R97C	SIDM00282	Colorectal Carcinoma	GDSC	LCVFPD	LIG_APCC_ABBA_1	0.0556
p.R97C	SIDM00585	Hepatocellular Carcinoma	GDSC	LCVFPD	LIG_APCC_ABBA_1	0.0556
p.R97C	SIDM00292	Small Cell Lung Carcinoma	GDSC	LCVFPD	LIG_APCC_ABBA_1	0.0556
p.R97C	SIDM00237	Non-Small Cell Lung Carcinoma	GDSC	LCVFPD	LIG_APCC_ABBA_1	0.0556
p.R97C	SIDM00498	Colorectal Carcinoma	GDSC	LCVFPD	LIG_APCC_ABBA_1	0.0556
p.R97C	SIDM00298	Squamous Cell Lung Carcinoma	GDSC	LCVFPD	LIG_APCC_ABBA_1	0.0556
p.R97C	SIDM00567	Other Solid Cancers	GDSC	LCVFPD	LIG_APCC_ABBA_1	0.0556
p.R97C	SIDM01653	Non-Cancerous	GDSC	LCVFPD	LIG_APCC_ABBA_1	0.0556
p.R97C	SIDM00283	B-Cell Non-Hodgkin's Lymphoma	GDSC	LCVFPD	LIG_APCC_ABBA_1	0.0556
p.R97C	SIDM00207	Glioblastoma	GDSC	LCVFPD	LIG_APCC_ABBA_1	0.0556
p.R97C	SIDM00655	Other Solid Cancers	GDSC	LCVFPD	LIG_APCC_ABBA_1	0.0556
p.R97C	SIDM00324	Neuroblastoma	GDSC	LCVFPD	LIG_APCC_ABBA_1	0.0556
p.R97C	SIDM00448	B-Cell Non-Hodgkin's Lymphoma	GDSC	LCVFPD	LIG_APCC_ABBA_1	0.0556
p.R97C	SIDM01449	Pancreatic Carcinoma	GDSC	LCVFPD	LIG_APCC_ABBA_1	0.0556
p.R97C	SIDM01460	Glioma	GDSC	LCVFPD	LIG_APCC_ABBA_1	0.0556
p.R97C	SIDM01660	Kidney Carcinoma	GDSC	LCVFPD	LIG_APCC_ABBA_1	0.0556
p.R97C	SIDM01464	Pancreatic Carcinoma	GDSC	LCVFPD	LIG_APCC_ABBA_1	0.0556
p.R97C	SIDM01347	Ovarian Carcinoma	GDSC	LCVFPD	LIG_APCC_ABBA_1	0.0556
p.R97C	SIDM01435	Hepatocellular Carcinoma	GDSC	LCVFPD	LIG_APCC_ABBA_1	0.0556
p.R97C	SIDM01446	Glioblastoma	GDSC	LCVFPD	LIG_APCC_ABBA_1	0.0556
p.R97C	SIDM01473	Plasma Cell Myeloma	GDSC	LCVFPD	LIG_APCC_ABBA_1	0.0556
p.C98F	DO228976	LICA	ICGC	LCVFPD	LIG_APCC_ABBA_1	0.0833
p.P111S	DO222843	MELA	ICGC	LCVFPD	LIG_APCC_ABBA_1	0.5641
p.L121I	SIDM01950	Colorectal Carcinoma	GDSC	LCVFPD	LIG_APCC_ABBA_1	0.0833
p.A105V	SIDM00698	Small Cell Lung Carcinoma	GDSC	LCVFPD	LIG_APCC_ABBA_1	0.2778
p.A105V	SIDM00649	Non-Small Cell Lung Carcinoma	GDSC	LCVFPD	LIG_APCC_ABBA_1	0.2778
p.A105V	SIDM00386	Ewing's Sarcoma	GDSC	LCVFPD	LIG_APCC_ABBA_1	0.2778
p.A105V	SIDM00812	Colorectal Carcinoma	GDSC	LCVFPD	LIG_APCC_ABBA_1	0.2778
p.A105V	SIDM00013	Melanoma	GDSC	LCVFPD	LIG_APCC_ABBA_1	0.2778
p.A105V	SIDM01073	Other Blood Cancers	GDSC	LCVFPD	LIG_APCC_ABBA_1	0.2778
p.A105V	SIDM01003	T-Lymphoblastic Leukemia	GDSC	LCVFPD	LIG_APCC_ABBA_1	0.2778
p.A105V	SIDM00049	Colorectal Carcinoma	GDSC	LCVFPD	LIG_APCC_ABBA_1	0.2778
p.A105V	SIDM00685	Glioblastoma	GDSC	LCVFPD	LIG_APCC_ABBA_1	0.2778
p.A105V	SIDM00387	Neuroblastoma	GDSC	LCVFPD	LIG_APCC_ABBA_1	0.2778
p.A105V	SIDM01491	Colorectal Carcinoma	GDSC	LCVFPD	LIG_APCC_ABBA_1	0.2778
p.E106D	SIDM00850	Gastric Carcinoma	GDSC	LCVFPD	LIG_APCC_ABBA_1	0.3056
p.E106D	AGS	stomach	COSMIC	LCVFPD	LIG_APCC_ABBA_1	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LCVFPD

Degron related mutations and impact score

Drug responses associated with SLX4IP mutations

All proteins holding degron of LCVFPD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5VYV7	Protein SLX4IP	LIG_APCC_ABBA_1	107:112	LCVFPD	APC,CDC20,FZR1	0.6465	More...