DegronMD - Q2M3C7(SPHKAP)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S1209I	TCGA-17-Z031	LUAD	TCGA	YRYMLRDIE	DEG_APCC_DBOX_1	1195:1203	Mutation blocking phosphorylation signal	0.6111
p.S1209I	TCGA-29-1785	OV	TCGA	YRYMLRDIE	DEG_APCC_DBOX_1	1195:1203	Mutation blocking phosphorylation signal	0.6111
p.S1209I	DO31624	OV	ICGC	YRYMLRDIE	DEG_APCC_DBOX_1	1195:1203	Mutation blocking phosphorylation signal	0.6111
p.D1205E	TCGA-22-4594	LUSC	TCGA	YRYMLRDIE	DEG_APCC_DBOX_1	1195:1203	Mutation rewiring degron network	0.2778
p.D1205E	DO27476	LUSC	ICGC	YRYMLRDIE	DEG_APCC_DBOX_1	1195:1203	Mutation rewiring degron network	0.2778
p.P1510T	TCGA-33-4566	LUSC	TCGA	PPSSS	DEG_SPOP_SBC_1	1509:1513	Mutation altering degron motif	0.5919
p.P1510T	DO26790	LUSC	ICGC	PPSSS	DEG_SPOP_SBC_1	1509:1513	Mutation altering degron motif	0.5919
p.E1203Q	TCGA-43-8118	LUSC	TCGA	YRYMLRDIE	DEG_APCC_DBOX_1	1195:1203	Mutation altering degron motif	0.5633
p.E1203Q	DO45471	LUSC	ICGC	YRYMLRDIE	DEG_APCC_DBOX_1	1195:1203	Mutation altering degron motif	0.5633
p.I467F	TCGA-49-AAR0	LUAD	TCGA	VETSS	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.0556
p.I467F	DO218917	LUAD	ICGC	VETSS	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.0556
p.R1196K	TCGA-77-6842	LUSC	TCGA	YRYMLRDIE	DEG_APCC_DBOX_1	1195:1203	Mutation altering degron motif	0.7237
p.R1196K	DO27413	LUSC	ICGC	YRYMLRDIE	DEG_APCC_DBOX_1	1195:1203	Mutation altering degron motif	0.7237
p.T479P	TCGA-78-7155	LUAD	TCGA	VETSS	DEG_SPOP_SBC_1	477:481	Mutation altering degron motif	0.7031
p.T479P	DO23590	LUAD	ICGC	VETSS	DEG_SPOP_SBC_1	477:481	Mutation altering degron motif	0.7031
p.S469Y	TCGA-98-7454	LUSC	TCGA	VETSS	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.1111
p.S469Y	DO26460	LUSC	ICGC	VETSS	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.1111
p.M1198K	TCGA-AA-3819	COAD	TCGA	YRYMLRDIE	DEG_APCC_DBOX_1	1195:1203	Mutation altering degron motif	0.6951
p.M1198K	DO10590	COAD	ICGC	YRYMLRDIE	DEG_APCC_DBOX_1	1195:1203	Mutation altering degron motif	0.6951
p.S489R	TCGA-AA-3846	COAD	TCGA	VETSS	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.1111
p.S489R	DO8682	COAD	ICGC	VETSS	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.1111
p.S117Y	TCGA-AP-A0LM	UCEC	TCGA	PKENE	DEG_APCC_KENBOX_2	123:127	Mutation rewiring degron network	0.1667
p.S117Y	DO43306	UCEC	ICGC	PKENE	DEG_APCC_KENBOX_2	123:127	Mutation rewiring degron network	0.1667
p.L114I	TCGA-AP-A1DV	UCEC	TCGA	PKENE	DEG_APCC_KENBOX_2	123:127	Mutation rewiring degron network	0.0833
p.L114I	DO43186	UCEC	ICGC	PKENE	DEG_APCC_KENBOX_2	123:127	Mutation rewiring degron network	0.0833
p.G137R	TCGA-BA-6869	HNSC	TCGA	PKENE	DEG_APCC_KENBOX_2	123:127	Mutation rewiring degron network	0.0556
p.G137R	TCGA-W3-AA1V	SKCM	TCGA	PKENE	DEG_APCC_KENBOX_2	123:127	Mutation rewiring degron network	0.0556
p.G137R	DO14250	HNSC	ICGC	PKENE	DEG_APCC_KENBOX_2	123:127	Mutation rewiring degron network	0.0556
p.G137R	DO51276	SKCM	ICGC	PKENE	DEG_APCC_KENBOX_2	123:127	Mutation rewiring degron network	0.0556
p.D822N	TCGA-BF-AAOX	SKCM	TCGA	PDSST	DEG_SPOP_SBC_1	821:825	Mutation altering degron motif	0.5821
p.D822N	TCGA-FS-A1Z3	SKCM	TCGA	PDSST	DEG_SPOP_SBC_1	821:825	Mutation altering degron motif	0.5821
p.D822N	DO37635	SKCM	ICGC	PDSST	DEG_SPOP_SBC_1	821:825	Mutation altering degron motif	0.5821
p.D822N	DO223907	SKCM	ICGC	PDSST	DEG_SPOP_SBC_1	821:825	Mutation altering degron motif	0.5821
p.D822N	SIDM00612	Glioma	GDSC	PDSST	DEG_SPOP_SBC_1	821:825	Mutation altering degron motif	0.5821
p.D822N	ACH-002257	Brain Cancer	CCLE	PDSST	DEG_SPOP_SBC_1	821:825	Mutation altering degron motif	0.5821
p.D822N	KINGS-1	central nervous system	COSMIC	PDSST	DEG_SPOP_SBC_1	821:825	Mutation altering degron motif	0.5821
p.A1210S	TCGA-CA-6716	COAD	TCGA	YRYMLRDIE	DEG_APCC_DBOX_1	1195:1203	Mutation rewiring degron network	0.1389
p.A1210S	DO9618	COAD	ICGC	YRYMLRDIE	DEG_APCC_DBOX_1	1195:1203	Mutation rewiring degron network	0.1389
p.L483F	TCGA-D9-A6EA	SKCM	TCGA	VETSS	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.2778
p.L483F	DO222550	MELA	ICGC	VETSS	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.2778
p.L483F	DO50290	SKCM	ICGC	VETSS	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.2778
p.G837E	TCGA-D9-A6EC	SKCM	TCGA	ATTSS	DEG_SPOP_SBC_1	826:830	Mutation rewiring degron network	0.1389
p.G837E	TCGA-Z2-A8RT	SKCM	TCGA	ATTSS	DEG_SPOP_SBC_1	826:830	Mutation rewiring degron network	0.1389
p.G837E	DO50291	SKCM	ICGC	ATTSS	DEG_SPOP_SBC_1	826:830	Mutation rewiring degron network	0.1389
p.G837E	DO51301	SKCM	ICGC	ATTSS	DEG_SPOP_SBC_1	826:830	Mutation rewiring degron network	0.1389
p.P1509T	TCGA-DK-AA6U	BLCA	TCGA	PPSSS	DEG_SPOP_SBC_1	1509:1513	Mutation altering degron motif	0.7031
p.P1509T	DO219008	BLCA	ICGC	PPSSS	DEG_SPOP_SBC_1	1509:1513	Mutation altering degron motif	0.7031
p.P1509T	DO229006	LICA	ICGC	PPSSS	DEG_SPOP_SBC_1	1509:1513	Mutation altering degron motif	0.7031
p.P1509T	SIDM00373	Endometrial Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	1509:1513	Mutation altering degron motif	0.7031
p.P1509T	ACH-000974	Endometrial/Uterine Cancer	CCLE	PPSSS	DEG_SPOP_SBC_1	1509:1513	Mutation altering degron motif	0.7031
p.P1509T	ACH-001532	Rhabdoid	CCLE	PPSSS	DEG_SPOP_SBC_1	1509:1513	Mutation altering degron motif	0.7031
p.P1509T	ACH-002026	Endometrial/Uterine Cancer	CCLE	PPSSS	DEG_SPOP_SBC_1	1509:1513	Mutation altering degron motif	0.7031
p.P1509T	SNG-M	endometrium	COSMIC	PPSSS	DEG_SPOP_SBC_1	1509:1513	Mutation altering degron motif	0.7031
p.T827K	TCGA-DX-A6BK	SARC	TCGA	ATTSS	DEG_SPOP_SBC_1	826:830	Mutation altering degron motif	0.6195
p.T827K	DO220001	SARC	ICGC	ATTSS	DEG_SPOP_SBC_1	826:830	Mutation altering degron motif	0.6195
p.K124R	TCGA-E7-A7XN	BLCA	TCGA	PKENE	DEG_APCC_KENBOX_2	123:127	Mutation altering degron motif	0.7237
p.K124R	DO51878	BLCA	ICGC	PKENE	DEG_APCC_KENBOX_2	123:127	Mutation altering degron motif	0.7237
p.L114V	TCGA-E7-A7XN	BLCA	TCGA	PKENE	DEG_APCC_KENBOX_2	123:127	Mutation rewiring degron network	0.0833
p.L114V	DO51878	BLCA	ICGC	PKENE	DEG_APCC_KENBOX_2	123:127	Mutation rewiring degron network	0.0833
p.E832K	TCGA-EB-A299	SKCM	TCGA	PDSST	DEG_SPOP_SBC_1	821:825	Mutation rewiring degron network	0.1389
p.E832K	TCGA-EB-A299	SKCM	TCGA	ATTSS	DEG_SPOP_SBC_1	826:830	Mutation rewiring degron network	0.2778
p.E832K	TCGA-EB-A4IS	SKCM	TCGA	PDSST	DEG_SPOP_SBC_1	821:825	Mutation rewiring degron network	0.1389
p.E832K	TCGA-EB-A4IS	SKCM	TCGA	ATTSS	DEG_SPOP_SBC_1	826:830	Mutation rewiring degron network	0.2778
p.E832K	TCGA-FR-A3YO	SKCM	TCGA	PDSST	DEG_SPOP_SBC_1	821:825	Mutation rewiring degron network	0.1389
p.E832K	TCGA-FR-A3YO	SKCM	TCGA	ATTSS	DEG_SPOP_SBC_1	826:830	Mutation rewiring degron network	0.2778
p.E832K	DO222753	MELA	ICGC	PDSST	DEG_SPOP_SBC_1	821:825	Mutation rewiring degron network	0.1389
p.E832K	DO222753	MELA	ICGC	ATTSS	DEG_SPOP_SBC_1	826:830	Mutation rewiring degron network	0.2778
p.E832K	DO222875	MELA	ICGC	PDSST	DEG_SPOP_SBC_1	821:825	Mutation rewiring degron network	0.1389
p.E832K	DO222875	MELA	ICGC	ATTSS	DEG_SPOP_SBC_1	826:830	Mutation rewiring degron network	0.2778
p.E832K	DO47281	SKCM	ICGC	PDSST	DEG_SPOP_SBC_1	821:825	Mutation rewiring degron network	0.1389
p.E832K	DO47281	SKCM	ICGC	ATTSS	DEG_SPOP_SBC_1	826:830	Mutation rewiring degron network	0.2778
p.E832K	DO37794	SKCM	ICGC	PDSST	DEG_SPOP_SBC_1	821:825	Mutation rewiring degron network	0.1389
p.E832K	DO37794	SKCM	ICGC	ATTSS	DEG_SPOP_SBC_1	826:830	Mutation rewiring degron network	0.2778
p.E832K	DO37419	SKCM	ICGC	PDSST	DEG_SPOP_SBC_1	821:825	Mutation rewiring degron network	0.1389
p.E832K	DO37419	SKCM	ICGC	ATTSS	DEG_SPOP_SBC_1	826:830	Mutation rewiring degron network	0.2778
p.S830F	TCGA-EE-A29A	SKCM	TCGA	ATTSS	DEG_SPOP_SBC_1	826:830	Mutation altering degron motif	0.7982
p.S830F	DO37416	SKCM	ICGC	ATTSS	DEG_SPOP_SBC_1	826:830	Mutation altering degron motif	0.7982
p.A1502T	TCGA-EE-A29E	SKCM	TCGA	PPSSS	DEG_SPOP_SBC_1	1509:1513	Mutation rewiring degron network	0.1389
p.A1502T	DO37831	SKCM	ICGC	PPSSS	DEG_SPOP_SBC_1	1509:1513	Mutation rewiring degron network	0.1389
p.R1204I	TCGA-EE-A2GC	SKCM	TCGA	YRYMLRDIE	DEG_APCC_DBOX_1	1195:1203	Mutation rewiring degron network	0.3056
p.R1204I	DO37839	SKCM	ICGC	YRYMLRDIE	DEG_APCC_DBOX_1	1195:1203	Mutation rewiring degron network	0.3056
p.E478K	TCGA-EE-A2GM	SKCM	TCGA	VETSS	DEG_SPOP_SBC_1	477:481	Mutation altering degron motif	0.591
p.E478K	DO37555	SKCM	ICGC	VETSS	DEG_SPOP_SBC_1	477:481	Mutation altering degron motif	0.591
p.S1516R	TCGA-EK-A2RA	CESC	TCGA	PPSSS	DEG_SPOP_SBC_1	1509:1513	Mutation rewiring degron network	0.25
p.S1516R	DO51601	CESC	ICGC	PPSSS	DEG_SPOP_SBC_1	1509:1513	Mutation rewiring degron network	0.25
p.L114R	TCGA-EO-A22X	UCEC	TCGA	PKENE	DEG_APCC_KENBOX_2	123:127	Mutation rewiring degron network	0.0833
p.L114R	TCGA-EY-A1GI	UCEC	TCGA	PKENE	DEG_APCC_KENBOX_2	123:127	Mutation rewiring degron network	0.0833
p.L114R	DO43907	UCEC	ICGC	PKENE	DEG_APCC_KENBOX_2	123:127	Mutation rewiring degron network	0.0833
p.L114R	DO41211	UCEC	ICGC	PKENE	DEG_APCC_KENBOX_2	123:127	Mutation rewiring degron network	0.0833
p.P1507S	TCGA-ER-A19F	SKCM	TCGA	PPSSS	DEG_SPOP_SBC_1	1509:1513	Mutation rewiring degron network	0.2778
p.P1507S	DO37679	SKCM	ICGC	PPSSS	DEG_SPOP_SBC_1	1509:1513	Mutation rewiring degron network	0.2778
p.T479I	TCGA-ER-A19G	SKCM	TCGA	VETSS	DEG_SPOP_SBC_1	477:481	Mutation altering degron motif	0.7078
p.T479I	DO47284	SKCM	ICGC	VETSS	DEG_SPOP_SBC_1	477:481	Mutation altering degron motif	0.7078
p.E1203K	TCGA-F4-6856	COAD	TCGA	YRYMLRDIE	DEG_APCC_DBOX_1	1195:1203	Mutation altering degron motif	0.591
p.E1203K	TCGA-GF-A6C9	SKCM	TCGA	YRYMLRDIE	DEG_APCC_DBOX_1	1195:1203	Mutation altering degron motif	0.591
p.E1203K	DO218709	BRCA	ICGC	YRYMLRDIE	DEG_APCC_DBOX_1	1195:1203	Mutation altering degron motif	0.591
p.E1203K	DO9114	COAD	ICGC	YRYMLRDIE	DEG_APCC_DBOX_1	1195:1203	Mutation altering degron motif	0.591
p.E1203K	DO220857	MELA	ICGC	YRYMLRDIE	DEG_APCC_DBOX_1	1195:1203	Mutation altering degron motif	0.591
p.E1203K	DO229453	SKCA	ICGC	YRYMLRDIE	DEG_APCC_DBOX_1	1195:1203	Mutation altering degron motif	0.591
p.E1203K	DO51254	SKCM	ICGC	YRYMLRDIE	DEG_APCC_DBOX_1	1195:1203	Mutation altering degron motif	0.591
p.E1203K	SIDM01113	Other Sarcomas	GDSC	YRYMLRDIE	DEG_APCC_DBOX_1	1195:1203	Mutation altering degron motif	0.591
p.E1203K	ACH-000939	Sarcoma	CCLE	YRYMLRDIE	DEG_APCC_DBOX_1	1195:1203	Mutation altering degron motif	0.591
p.E1203K	SK-UT-1	soft tissue	COSMIC	YRYMLRDIE	DEG_APCC_DBOX_1	1195:1203	Mutation altering degron motif	0.591
p.V477A	TCGA-FI-A2D5	UCEC	TCGA	VETSS	DEG_SPOP_SBC_1	477:481	Mutation altering degron motif	0.5825
p.V477A	DO41331	UCEC	ICGC	VETSS	DEG_SPOP_SBC_1	477:481	Mutation altering degron motif	0.5825
p.E1515K	TCGA-FW-A3R5	SKCM	TCGA	PPSSS	DEG_SPOP_SBC_1	1509:1513	Mutation rewiring degron network	0.2778
p.E1515K	DO229462	SKCA	ICGC	PPSSS	DEG_SPOP_SBC_1	1509:1513	Mutation rewiring degron network	0.2778
p.E1515K	DO37406	SKCM	ICGC	PPSSS	DEG_SPOP_SBC_1	1509:1513	Mutation rewiring degron network	0.2778
p.S468F	TCGA-QB-AA9O	SKCM	TCGA	VETSS	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.0833
p.S468F	DO51267	SKCM	ICGC	VETSS	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.0833
p.M118I	TCGA-TN-A7HL	HNSC	TCGA	PKENE	DEG_APCC_KENBOX_2	123:127	Mutation rewiring degron network	0.1944
p.M118I	DO219080	HNSC	ICGC	PKENE	DEG_APCC_KENBOX_2	123:127	Mutation rewiring degron network	0.1944
p.S829F	TCGA-W3-A824	SKCM	TCGA	ATTSS	DEG_SPOP_SBC_1	826:830	Mutation altering degron motif	0.7982
p.S829F	DO51271	SKCM	ICGC	ATTSS	DEG_SPOP_SBC_1	826:830	Mutation altering degron motif	0.7982
p.G137E	TCGA-W3-AA1O	SKCM	TCGA	PKENE	DEG_APCC_KENBOX_2	123:127	Mutation rewiring degron network	0.0556
p.G137E	DO51274	SKCM	ICGC	PKENE	DEG_APCC_KENBOX_2	123:127	Mutation rewiring degron network	0.0556
p.G485R	TCGA-W3-AA1R	SKCM	TCGA	VETSS	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.2222
p.G485R	DO51275	SKCM	ICGC	VETSS	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.2222
p.R816H	TCGA-ZG-A8QY	PRAD	TCGA	PDSST	DEG_SPOP_SBC_1	821:825	Mutation rewiring degron network	0.1944
p.R816H	TCGA-ZG-A8QY	PRAD	TCGA	ATTSS	DEG_SPOP_SBC_1	826:830	Mutation rewiring degron network	0.0556
p.R816H	DO51449	PRAD	ICGC	PDSST	DEG_SPOP_SBC_1	821:825	Mutation rewiring degron network	0.1944
p.R816H	DO51449	PRAD	ICGC	ATTSS	DEG_SPOP_SBC_1	826:830	Mutation rewiring degron network	0.0556
p.D1205G	DO7801	COAD	ICGC	YRYMLRDIE	DEG_APCC_DBOX_1	1195:1203	Mutation rewiring degron network	0.2778
p.I128T	DO8264	COAD	ICGC	PKENE	DEG_APCC_KENBOX_2	123:127	Mutation rewiring degron network	0.3056
p.D822H	DO223093	ESCA	ICGC	PDSST	DEG_SPOP_SBC_1	821:825	Mutation altering degron motif	0.6577
p.S1519T	DO228522	LICA	ICGC	PPSSS	DEG_SPOP_SBC_1	1509:1513	Mutation rewiring degron network	0.1667
p.Q122K	DO228971	LICA	ICGC	PKENE	DEG_APCC_KENBOX_2	123:127	Mutation rewiring degron network	0.3056
p.P1510Q	DO229025	LICA	ICGC	PPSSS	DEG_SPOP_SBC_1	1509:1513	Mutation altering degron motif	0.5924
p.A1506D	DO229035	LICA	ICGC	PPSSS	DEG_SPOP_SBC_1	1509:1513	Mutation rewiring degron network	0.25
p.S1511R	DO229009	LICA	ICGC	PPSSS	DEG_SPOP_SBC_1	1509:1513	Mutation altering degron motif	0.7427
p.P1503T	DO23268	LINC	ICGC	PPSSS	DEG_SPOP_SBC_1	1509:1513	Mutation rewiring degron network	0.1667
p.L131Q	DO23316	LINC	ICGC	PKENE	DEG_APCC_KENBOX_2	123:127	Mutation rewiring degron network	0.2222
p.Y834C	DO229098	LMS	ICGC	PDSST	DEG_SPOP_SBC_1	821:825	Mutation rewiring degron network	0.0833
p.Y834C	DO229098	LMS	ICGC	ATTSS	DEG_SPOP_SBC_1	826:830	Mutation rewiring degron network	0.2222
p.R1207K	DO231091	LUSC	ICGC	YRYMLRDIE	DEG_APCC_DBOX_1	1195:1203	Mutation rewiring degron network	0.2222
p.R1207K	DO222843	MELA	ICGC	YRYMLRDIE	DEG_APCC_DBOX_1	1195:1203	Mutation rewiring degron network	0.2222
p.V129A	DO222399	MELA	ICGC	PKENE	DEG_APCC_KENBOX_2	123:127	Mutation rewiring degron network	0.2778
p.S815L	DO222632	MELA	ICGC	PDSST	DEG_SPOP_SBC_1	821:825	Mutation rewiring degron network	0.1667
p.M473I	DO222837	MELA	ICGC	VETSS	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.2222
p.G485E	DO222843	MELA	ICGC	VETSS	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.2222
p.E1188D	DO222843	MELA	ICGC	YRYMLRDIE	DEG_APCC_DBOX_1	1195:1203	Mutation rewiring degron network	0.1389
p.S1185Y	DO232224	PBCA	ICGC	YRYMLRDIE	DEG_APCC_DBOX_1	1195:1203	Mutation rewiring degron network	0.0556
p.N1508S	DO219878	SKCA	ICGC	PPSSS	DEG_SPOP_SBC_1	1509:1513	Mutation rewiring degron network	0.3056
p.A1500T	DO229453	SKCA	ICGC	PPSSS	DEG_SPOP_SBC_1	1509:1513	Mutation rewiring degron network	0.0833
p.E127K	DO229456	SKCA	ICGC	PKENE	DEG_APCC_KENBOX_2	123:127	Mutation altering degron motif	0.591
p.E474K	DO218900	SKCA	ICGC	VETSS	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.25
p.I115S	SIDM00270	Head and Neck Carcinoma	GDSC	PKENE	DEG_APCC_KENBOX_2	123:127	Mutation rewiring degron network	0.1111
p.I115S	ACH-002294	Head and Neck Cancer	CCLE	PKENE	DEG_APCC_KENBOX_2	123:127	Mutation rewiring degron network	0.1111
p.I115S	PCI-15A	upper aerodigestive tract	COSMIC	PKENE	DEG_APCC_KENBOX_2	123:127	Mutation rewiring degron network	0.1111
p.D1504N	SIDM01021	Glioblastoma	GDSC	PPSSS	DEG_SPOP_SBC_1	1509:1513	Mutation rewiring degron network	0.1944
p.D1504N	SIDM00594	Acute Myeloid Leukemia	GDSC	PPSSS	DEG_SPOP_SBC_1	1509:1513	Mutation rewiring degron network	0.1944
p.P821S	SIDM01090	Colorectal Carcinoma	GDSC	PDSST	DEG_SPOP_SBC_1	821:825	Mutation altering degron motif	0.6752
p.P821S	ACH-000943	Colon/Colorectal Cancer	CCLE	PDSST	DEG_SPOP_SBC_1	821:825	Mutation altering degron motif	0.6752
p.P821S	RKO	large intestine	COSMIC	PDSST	DEG_SPOP_SBC_1	821:825	Mutation altering degron motif	0.6752
p.H818Y	SIDM01183	Other Solid Cancers	GDSC	PDSST	DEG_SPOP_SBC_1	821:825	Mutation rewiring degron network	0.25
p.H818Y	SIDM01183	Other Solid Cancers	GDSC	ATTSS	DEG_SPOP_SBC_1	826:830	Mutation rewiring degron network	0.1111
p.H818Y	ACH-001417	Lung Cancer	CCLE	PDSST	DEG_SPOP_SBC_1	821:825	Mutation rewiring degron network	0.25
p.H818Y	ACH-001417	Lung Cancer	CCLE	ATTSS	DEG_SPOP_SBC_1	826:830	Mutation rewiring degron network	0.1111
p.H818Y	UMC-11	lung	COSMIC	PDSST	DEG_SPOP_SBC_1	821:825	Mutation rewiring degron network	0.25
p.H818Y	UMC-11	lung	COSMIC	ATTSS	DEG_SPOP_SBC_1	826:830	Mutation rewiring degron network	0.1111
p.E1192K	SIDM00506	Small Cell Lung Carcinoma	GDSC	YRYMLRDIE	DEG_APCC_DBOX_1	1195:1203	Mutation rewiring degron network	0.25
p.E1192K	ACH-000508	Lung Cancer	CCLE	YRYMLRDIE	DEG_APCC_DBOX_1	1195:1203	Mutation rewiring degron network	0.25
p.E1192K	COR-L88	lung	COSMIC	YRYMLRDIE	DEG_APCC_DBOX_1	1195:1203	Mutation rewiring degron network	0.25
p.S484F	SIDM00007	Other Solid Cancers	GDSC	VETSS	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.25
p.S484F	ACH-001550	Skin Cancer	CCLE	VETSS	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.25
p.S484F	MCC13	skin	COSMIC	VETSS	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.25
p.S823F	SIDM00193	Colorectal Carcinoma	GDSC	PDSST	DEG_SPOP_SBC_1	821:825	Mutation altering degron motif	0.7982
p.S823F	ACH-000991	Colon/Colorectal Cancer	CCLE	PDSST	DEG_SPOP_SBC_1	821:825	Mutation altering degron motif	0.7982
p.S823F	SNU-81	large intestine	COSMIC	PDSST	DEG_SPOP_SBC_1	821:825	Mutation altering degron motif	0.7982
p.G840V	SIDM01162	Kidney Carcinoma	GDSC	ATTSS	DEG_SPOP_SBC_1	826:830	Mutation rewiring degron network	0.0556
p.G840V	ACH-001398	Kidney Cancer	CCLE	ATTSS	DEG_SPOP_SBC_1	826:830	Mutation rewiring degron network	0.0556
p.G840V	SW156	kidney	COSMIC	ATTSS	DEG_SPOP_SBC_1	826:830	Mutation rewiring degron network	0.0556
p.V477F	SIDM00507	Other Solid Cancers	GDSC	VETSS	DEG_SPOP_SBC_1	477:481	Mutation altering degron motif	0.7068
p.V477F	ACH-001490	Lung Cancer	CCLE	VETSS	DEG_SPOP_SBC_1	477:481	Mutation altering degron motif	0.7068
p.V477F	COR-L321	NS	COSMIC	VETSS	DEG_SPOP_SBC_1	477:481	Mutation altering degron motif	0.7068
p.A1210V	SIDM00282	Colorectal Carcinoma	GDSC	YRYMLRDIE	DEG_APCC_DBOX_1	1195:1203	Mutation rewiring degron network	0.1389
p.A1210V	ACH-000998	Colon/Colorectal Cancer	CCLE	YRYMLRDIE	DEG_APCC_DBOX_1	1195:1203	Mutation rewiring degron network	0.1389
p.A1210V	CW-2	large intestine	COSMIC	YRYMLRDIE	DEG_APCC_DBOX_1	1195:1203	Mutation rewiring degron network	0.1389
p.W470G	SIDM00965	Small Cell Lung Carcinoma	GDSC	VETSS	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.1389
p.W470G	ACH-000800	Lung Cancer	CCLE	VETSS	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.1389
p.W470G	NCI-H446	lung	COSMIC	VETSS	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.1389
p.T827A	SIDM01680	Non-Cancerous	GDSC	ATTSS	DEG_SPOP_SBC_1	826:830	Mutation altering degron motif	0.6028
p.T827A	ACH-002364	Non-Cancerous	CCLE	ATTSS	DEG_SPOP_SBC_1	826:830	Mutation altering degron motif	0.6028
p.L1199P	SIDM01043	Other Sarcomas	GDSC	YRYMLRDIE	DEG_APCC_DBOX_1	1195:1203	Mutation altering degron motif	0.7582
p.L1199P	ACH-000913	Endometrial/Uterine Cancer	CCLE	YRYMLRDIE	DEG_APCC_DBOX_1	1195:1203	Mutation altering degron motif	0.7582
p.L1199P	ESS-1	endometrium	COSMIC	YRYMLRDIE	DEG_APCC_DBOX_1	1195:1203	Mutation altering degron motif	0.7582
p.Q813H	SIDM00451	T-Lymphoblastic Leukemia	GDSC	PDSST	DEG_SPOP_SBC_1	821:825	Mutation rewiring degron network	0.1111
p.Q813H	ACH-000937	Leukemia	CCLE	PDSST	DEG_SPOP_SBC_1	821:825	Mutation rewiring degron network	0.1111
p.Q813H	PF-382	haematopoietic and lymphoid tissue	COSMIC	PDSST	DEG_SPOP_SBC_1	821:825	Mutation rewiring degron network	0.1111
p.V477I	SIDM00150	Colorectal Carcinoma	GDSC	VETSS	DEG_SPOP_SBC_1	477:481	Mutation altering degron motif	0.7076
p.V477I	ACH-000969	Colon/Colorectal Cancer	CCLE	VETSS	DEG_SPOP_SBC_1	477:481	Mutation altering degron motif	0.7076
p.V477I	KM12	large intestine	COSMIC	VETSS	DEG_SPOP_SBC_1	477:481	Mutation altering degron motif	0.7076
p.S132G	ACH-000700	Lung Cancer	CCLE	PKENE	DEG_APCC_KENBOX_2	123:127	Mutation rewiring degron network	0.1944
p.S1211F	ACH-002396	Bone Cancer	CCLE	YRYMLRDIE	DEG_APCC_DBOX_1	1195:1203	Mutation blocking phosphorylation signal	0.5556
p.S1211F	Sarc9371	bone	COSMIC	YRYMLRDIE	DEG_APCC_DBOX_1	1195:1203	Mutation blocking phosphorylation signal	0.5556
p.A1500S	ACH-002399	Breast Cancer	CCLE	PPSSS	DEG_SPOP_SBC_1	1509:1513	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SPHKAP

UniProt ID: Q2M3C7

Entrez ID: 80309

Protein name: A-kinase anchor protein SPHKAP (SPHK1-interactor and AKAP domain-containing protein) (Sphingosine kinase type 1-interacting protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SPHKAP in