DegronMD

Uniprot ID: Q2M3C7

Source protein: A-kinase anchor protein SPHKAP

Source gene: SPHKAP

Class: DEG_APCC_KENBOX_2

Location: 123:127

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.774

ASA_SCORE: 69.1

COIL: 0.7296

CONS_SCORE: 0.8666

DSS_SCORE: 0.2795

HELIX: 0.0724

FCONS_SCORE: 1.3025

RIG_SCORE: 0.7728

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S117Y	TCGA-AP-A0LM	UCEC	TCGA	PKENE	DEG_APCC_KENBOX_2	0.1667
p.S117Y	DO43306	UCEC	ICGC	PKENE	DEG_APCC_KENBOX_2	0.1667
p.L114I	TCGA-AP-A1DV	UCEC	TCGA	PKENE	DEG_APCC_KENBOX_2	0.0833
p.L114I	DO43186	UCEC	ICGC	PKENE	DEG_APCC_KENBOX_2	0.0833
p.G137R	TCGA-BA-6869	HNSC	TCGA	PKENE	DEG_APCC_KENBOX_2	0.0556
p.G137R	TCGA-W3-AA1V	SKCM	TCGA	PKENE	DEG_APCC_KENBOX_2	0.0556
p.G137R	DO14250	HNSC	ICGC	PKENE	DEG_APCC_KENBOX_2	0.0556
p.G137R	DO51276	SKCM	ICGC	PKENE	DEG_APCC_KENBOX_2	0.0556
p.K124R	TCGA-E7-A7XN	BLCA	TCGA	PKENE	DEG_APCC_KENBOX_2	0.7237
p.K124R	DO51878	BLCA	ICGC	PKENE	DEG_APCC_KENBOX_2	0.7237
p.L114V	TCGA-E7-A7XN	BLCA	TCGA	PKENE	DEG_APCC_KENBOX_2	0.0833
p.L114V	DO51878	BLCA	ICGC	PKENE	DEG_APCC_KENBOX_2	0.0833
p.L114R	TCGA-EO-A22X	UCEC	TCGA	PKENE	DEG_APCC_KENBOX_2	0.0833
p.L114R	TCGA-EY-A1GI	UCEC	TCGA	PKENE	DEG_APCC_KENBOX_2	0.0833
p.L114R	DO43907	UCEC	ICGC	PKENE	DEG_APCC_KENBOX_2	0.0833
p.L114R	DO41211	UCEC	ICGC	PKENE	DEG_APCC_KENBOX_2	0.0833
p.M118I	TCGA-TN-A7HL	HNSC	TCGA	PKENE	DEG_APCC_KENBOX_2	0.1944
p.M118I	DO219080	HNSC	ICGC	PKENE	DEG_APCC_KENBOX_2	0.1944
p.G137E	TCGA-W3-AA1O	SKCM	TCGA	PKENE	DEG_APCC_KENBOX_2	0.0556
p.G137E	DO51274	SKCM	ICGC	PKENE	DEG_APCC_KENBOX_2	0.0556
p.I128T	DO8264	COAD	ICGC	PKENE	DEG_APCC_KENBOX_2	0.3056
p.Q122K	DO228971	LICA	ICGC	PKENE	DEG_APCC_KENBOX_2	0.3056
p.L131Q	DO23316	LINC	ICGC	PKENE	DEG_APCC_KENBOX_2	0.2222
p.V129A	DO222399	MELA	ICGC	PKENE	DEG_APCC_KENBOX_2	0.2778
p.E127K	DO229456	SKCA	ICGC	PKENE	DEG_APCC_KENBOX_2	0.591
p.I115S	SIDM00270	Head and Neck Carcinoma	GDSC	PKENE	DEG_APCC_KENBOX_2	0.1111
p.I115S	ACH-002294	Head and Neck Cancer	CCLE	PKENE	DEG_APCC_KENBOX_2	0.1111
p.I115S	PCI-15A	upper_aerodigestive_tract	COSMIC	PKENE	DEG_APCC_KENBOX_2	0.1111
p.S132G	ACH-000700	Lung Cancer	CCLE	PKENE	DEG_APCC_KENBOX_2	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q2M3C7	A-kinase anchor protein SPHKAP	DEG_APCC_KENBOX_2	123:127	PKENE	APC,CDC20,FZR1	0.774	More...
Q9H7U1	Serine-rich coiled-coil domain-containing protein 2	DEG_APCC_KENBOX_2	453:457	PKENE	APC,CDC20,FZR1	0.7463	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PKENE

Degron related mutations and impact score

Drug responses associated with SPHKAP mutations

All proteins holding degron of PKENE