DegronMD - Q9H7U1(CCSER2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G33E	TCGA-AA-3811	COAD	TCGA	VRSTLQPMP	DEG_APCC_DBOX_1	23:31	Mutation rewiring degron network	0.2778
p.G33E	DO7962	COAD	ICGC	VRSTLQPMP	DEG_APCC_DBOX_1	23:31	Mutation rewiring degron network	0.2778
p.R773Q	TCGA-AN-A046	BRCA	TCGA	DKYTQTP	CBL_PTK	764:770	Mutation rewiring degron network	0.25
p.R773Q	TCGA-EI-6917	READ	TCGA	DKYTQTP	CBL_PTK	764:770	Mutation rewiring degron network	0.25
p.R773Q	TCGA-FI-A2D5	UCEC	TCGA	DKYTQTP	CBL_PTK	764:770	Mutation rewiring degron network	0.25
p.R773Q	DO1285	BRCA	ICGC	DKYTQTP	CBL_PTK	764:770	Mutation rewiring degron network	0.25
p.R773Q	DO36881	READ	ICGC	DKYTQTP	CBL_PTK	764:770	Mutation rewiring degron network	0.25
p.R773Q	DO41331	UCEC	ICGC	DKYTQTP	CBL_PTK	764:770	Mutation rewiring degron network	0.25
p.T26A	TCGA-AP-A1DK	UCEC	TCGA	VRSTLQPMP	DEG_APCC_DBOX_1	23:31	Mutation altering degron motif	0.6028
p.T26A	DO42033	UCEC	ICGC	VRSTLQPMP	DEG_APCC_DBOX_1	23:31	Mutation altering degron motif	0.6028
p.P445S	TCGA-BR-8360	STAD	TCGA	PKENE	DEG_APCC_KENBOX_2	453:457	Mutation rewiring degron network	0.1111
p.P445S	DO47745	STAD	ICGC	PKENE	DEG_APCC_KENBOX_2	453:457	Mutation rewiring degron network	0.1111
p.N37Y	TCGA-CM-6168	COAD	TCGA	VRSTLQPMP	DEG_APCC_DBOX_1	23:31	Mutation rewiring degron network	0.1667
p.N37Y	DO9602	COAD	ICGC	VRSTLQPMP	DEG_APCC_DBOX_1	23:31	Mutation rewiring degron network	0.1667
p.Y766C	TCGA-CN-A497	HNSC	TCGA	DKYTQTP	CBL_PTK	764:770	Mutation altering degron motif	0.7087
p.Y766C	TCGA-CR-6491	HNSC	TCGA	DKYTQTP	CBL_PTK	764:770	Mutation altering degron motif	0.7087
p.Y766C	DO218992	HNSC	ICGC	DKYTQTP	CBL_PTK	764:770	Mutation altering degron motif	0.7087
p.Y766C	DO14192	HNSC	ICGC	DKYTQTP	CBL_PTK	764:770	Mutation altering degron motif	0.7087
p.G33W	TCGA-D3-A2JO	SKCM	TCGA	VRSTLQPMP	DEG_APCC_DBOX_1	23:31	Mutation rewiring degron network	0.2778
p.G33W	DO47619	SKCM	ICGC	VRSTLQPMP	DEG_APCC_DBOX_1	23:31	Mutation rewiring degron network	0.2778
p.S22Y	TCGA-EE-A181	SKCM	TCGA	VRSTLQPMP	DEG_APCC_DBOX_1	23:31	Mutation rewiring degron network	0.3056
p.S22Y	DO37444	SKCM	ICGC	VRSTLQPMP	DEG_APCC_DBOX_1	23:31	Mutation rewiring degron network	0.3056
p.E455D	TCGA-EE-A2M5	SKCM	TCGA	PKENE	DEG_APCC_KENBOX_2	453:457	Mutation altering degron motif	0.6758
p.E455D	DO222423	MELA	ICGC	PKENE	DEG_APCC_KENBOX_2	453:457	Mutation altering degron motif	0.6758
p.E455D	DO37425	SKCM	ICGC	PKENE	DEG_APCC_KENBOX_2	453:457	Mutation altering degron motif	0.6758
p.P35H	TCGA-EE-A2M7	SKCM	TCGA	VRSTLQPMP	DEG_APCC_DBOX_1	23:31	Mutation rewiring degron network	0.2222
p.P35H	DO37847	SKCM	ICGC	VRSTLQPMP	DEG_APCC_DBOX_1	23:31	Mutation rewiring degron network	0.2222
p.K21E	TCGA-EO-A22U	UCEC	TCGA	VRSTLQPMP	DEG_APCC_DBOX_1	23:31	Mutation rewiring degron network	0.2778
p.K21E	DO43755	UCEC	ICGC	VRSTLQPMP	DEG_APCC_DBOX_1	23:31	Mutation rewiring degron network	0.2778
p.N37H	TCGA-F5-6814	READ	TCGA	VRSTLQPMP	DEG_APCC_DBOX_1	23:31	Mutation rewiring degron network	0.1667
p.N37H	DO36556	READ	ICGC	VRSTLQPMP	DEG_APCC_DBOX_1	23:31	Mutation rewiring degron network	0.1667
p.K759T	TCGA-F5-6814	READ	TCGA	DKYTQTP	CBL_PTK	764:770	Mutation substituting flanking lysine	0.3056
p.K759T	DO36556	READ	ICGC	DKYTQTP	CBL_PTK	764:770	Mutation substituting flanking lysine	0.3056
p.P775L	TCGA-GN-A263	SKCM	TCGA	DKYTQTP	CBL_PTK	764:770	Mutation rewiring degron network	0.1944
p.P775L	DO37766	SKCM	ICGC	DKYTQTP	CBL_PTK	764:770	Mutation rewiring degron network	0.1944
p.A459G	TCGA-HC-7232	PRAD	TCGA	PKENE	DEG_APCC_KENBOX_2	453:457	Mutation rewiring degron network	0.2778
p.A459G	DO49799	PRAD	ICGC	PKENE	DEG_APCC_KENBOX_2	453:457	Mutation rewiring degron network	0.2778
p.K14T	TCGA-P3-A6SX	HNSC	TCGA	VRSTLQPMP	DEG_APCC_DBOX_1	23:31	Mutation substituting flanking lysine	0.1944
p.K14T	DO49051	HNSC	ICGC	VRSTLQPMP	DEG_APCC_DBOX_1	23:31	Mutation substituting flanking lysine	0.1944
p.P453L	TCGA-T3-A92N	HNSC	TCGA	PKENE	DEG_APCC_KENBOX_2	453:457	Mutation altering degron motif	0.6471
p.P453L	DO219073	HNSC	ICGC	PKENE	DEG_APCC_KENBOX_2	453:457	Mutation altering degron motif	0.6471
p.I774T	DO225340	BRCA	ICGC	DKYTQTP	CBL_PTK	764:770	Mutation rewiring degron network	0.2222
p.C760Y	DO233211	GACA	ICGC	DKYTQTP	CBL_PTK	764:770	Mutation rewiring degron network	0.2222
p.G40E	DO220875	MELA	ICGC	VRSTLQPMP	DEG_APCC_DBOX_1	23:31	Mutation rewiring degron network	0.0833
p.Y766H	SIDM00390	T-Cell Non-Hodgkin's Lymphoma	GDSC	DKYTQTP	CBL_PTK	764:770	Mutation altering degron motif	0.7229
p.Y766H	ACH-000664	Lymphoma	CCLE	DKYTQTP	CBL_PTK	764:770	Mutation altering degron motif	0.7229
p.Y766H	SU-DHL-1	haematopoietic and lymphoid tissue	COSMIC	DKYTQTP	CBL_PTK	764:770	Mutation altering degron motif	0.7229
p.S461N	SIDM00581	Glioblastoma	GDSC	PKENE	DEG_APCC_KENBOX_2	453:457	Mutation blocking phosphorylation signal	0.6667
p.S461N	ACH-000738	Brain Cancer	CCLE	PKENE	DEG_APCC_KENBOX_2	453:457	Mutation blocking phosphorylation signal	0.6667
p.S461N	GB-1	central nervous system	COSMIC	PKENE	DEG_APCC_KENBOX_2	453:457	Mutation blocking phosphorylation signal	0.6667
p.G33A	SIDM01120	Other Solid Cancers	GDSC	VRSTLQPMP	DEG_APCC_DBOX_1	23:31	Mutation rewiring degron network	0.2778
p.G33A	ACH-002174	Lung Cancer	CCLE	VRSTLQPMP	DEG_APCC_DBOX_1	23:31	Mutation rewiring degron network	0.2778
p.G33A	NCI-H720	lung	COSMIC	VRSTLQPMP	DEG_APCC_DBOX_1	23:31	Mutation rewiring degron network	0.2778
p.C755Y	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	DKYTQTP	CBL_PTK	764:770	Mutation rewiring degron network	0.0833
p.C755Y	ACH-002101	Lung Cancer	CCLE	DKYTQTP	CBL_PTK	764:770	Mutation rewiring degron network	0.0833
p.R24K	SIDM00749	Non-Small Cell Lung Carcinoma	GDSC	VRSTLQPMP	DEG_APCC_DBOX_1	23:31	Mutation altering degron motif	0.7237
p.R24K	ACH-000916	Lung Cancer	CCLE	VRSTLQPMP	DEG_APCC_DBOX_1	23:31	Mutation altering degron motif	0.7237
p.R24K	NCI-H1573	lung	COSMIC	VRSTLQPMP	DEG_APCC_DBOX_1	23:31	Mutation altering degron motif	0.7237
p.N37K	ACH-000971	Colon/Colorectal Cancer	CCLE	VRSTLQPMP	DEG_APCC_DBOX_1	23:31	Mutation rewiring degron network	0.1667
p.Y40C	ESO26	oesophagus	COSMIC	VRSTLQPMP	DEG_APCC_DBOX_1	23:31	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CCSER2

UniProt ID: Q9H7U1

Entrez ID: 54462

Protein name: Serine-rich coiled-coil domain-containing protein 2 (Coiled-coil serine-rich protein 2) (Protein GCAP14 homolog)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CCSER2 in