DegronMD

Uniprot ID: Q9H7U1

Source protein: Serine-rich coiled-coil domain-containing protein 2

Source gene: CCSER2

Class: DEG_APCC_KENBOX_2

Location: 453:457

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7463

ASA_SCORE: 89.54

COIL: 0.6108

CONS_SCORE: 0.5974

DSS_SCORE: 0.6902

HELIX: 0.3236

FCONS_SCORE: 1.1234

RIG_SCORE: 0.6659

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P445S	TCGA-BR-8360	STAD	TCGA	PKENE	DEG_APCC_KENBOX_2	0.1111
p.P445S	DO47745	STAD	ICGC	PKENE	DEG_APCC_KENBOX_2	0.1111
p.E455D	TCGA-EE-A2M5	SKCM	TCGA	PKENE	DEG_APCC_KENBOX_2	0.6758
p.E455D	DO222423	MELA	ICGC	PKENE	DEG_APCC_KENBOX_2	0.6758
p.E455D	DO37425	SKCM	ICGC	PKENE	DEG_APCC_KENBOX_2	0.6758
p.A459G	TCGA-HC-7232	PRAD	TCGA	PKENE	DEG_APCC_KENBOX_2	0.2778
p.A459G	DO49799	PRAD	ICGC	PKENE	DEG_APCC_KENBOX_2	0.2778
p.P453L	TCGA-T3-A92N	HNSC	TCGA	PKENE	DEG_APCC_KENBOX_2	0.6471
p.P453L	DO219073	HNSC	ICGC	PKENE	DEG_APCC_KENBOX_2	0.6471
p.S461N	SIDM00581	Glioblastoma	GDSC	PKENE	DEG_APCC_KENBOX_2	0.6667
p.S461N	ACH-000738	Brain Cancer	CCLE	PKENE	DEG_APCC_KENBOX_2	0.6667
p.S461N	GB-1	central_nervous_system	COSMIC	PKENE	DEG_APCC_KENBOX_2	0.6667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q2M3C7	A-kinase anchor protein SPHKAP	DEG_APCC_KENBOX_2	123:127	PKENE	APC,CDC20,FZR1	0.774	More...
Q9H7U1	Serine-rich coiled-coil domain-containing protein 2	DEG_APCC_KENBOX_2	453:457	PKENE	APC,CDC20,FZR1	0.7463	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons