DegronMD

Uniprot ID: Q9H7U1

Source protein: Serine-rich coiled-coil domain-containing protein 2

Source gene: CCSER2

Class: CBL_PTK

Location: 764:770

E3 ligase: CBL

DEGRON score: 0.9436

ASA_SCORE: 75.4429

COIL: 0.7221

CONS_SCORE: 0.7772

DSS_SCORE: 0.2923

HELIX: 0.0517

FCONS_SCORE: 1.2859

RIG_SCORE: 0.8384

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R773Q	TCGA-AN-A046	BRCA	TCGA	DKYTQTP	CBL_PTK	0.25
p.R773Q	TCGA-EI-6917	READ	TCGA	DKYTQTP	CBL_PTK	0.25
p.R773Q	TCGA-FI-A2D5	UCEC	TCGA	DKYTQTP	CBL_PTK	0.25
p.R773Q	DO1285	BRCA	ICGC	DKYTQTP	CBL_PTK	0.25
p.R773Q	DO36881	READ	ICGC	DKYTQTP	CBL_PTK	0.25
p.R773Q	DO41331	UCEC	ICGC	DKYTQTP	CBL_PTK	0.25
p.Y766C	TCGA-CN-A497	HNSC	TCGA	DKYTQTP	CBL_PTK	0.7087
p.Y766C	TCGA-CR-6491	HNSC	TCGA	DKYTQTP	CBL_PTK	0.7087
p.Y766C	DO218992	HNSC	ICGC	DKYTQTP	CBL_PTK	0.7087
p.Y766C	DO14192	HNSC	ICGC	DKYTQTP	CBL_PTK	0.7087
p.K759T	TCGA-F5-6814	READ	TCGA	DKYTQTP	CBL_PTK	0.3056
p.K759T	DO36556	READ	ICGC	DKYTQTP	CBL_PTK	0.3056
p.P775L	TCGA-GN-A263	SKCM	TCGA	DKYTQTP	CBL_PTK	0.1944
p.P775L	DO37766	SKCM	ICGC	DKYTQTP	CBL_PTK	0.1944
p.I774T	DO225340	BRCA	ICGC	DKYTQTP	CBL_PTK	0.2222
p.C760Y	DO233211	GACA	ICGC	DKYTQTP	CBL_PTK	0.2222
p.Y766H	SIDM00390	T-Cell Non-Hodgkin's Lymphoma	GDSC	DKYTQTP	CBL_PTK	0.7229
p.Y766H	ACH-000664	Lymphoma	CCLE	DKYTQTP	CBL_PTK	0.7229
p.Y766H	SU-DHL-1	haematopoietic_and_lymphoid_tissue	COSMIC	DKYTQTP	CBL_PTK	0.7229
p.C755Y	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	DKYTQTP	CBL_PTK	0.0833
p.C755Y	ACH-002101	Lung Cancer	CCLE	DKYTQTP	CBL_PTK	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H7U1	Serine-rich coiled-coil domain-containing protein 2	CBL_PTK	764:770	DKYTQTP	CBL	0.9436	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons