DegronMD

Uniprot ID: Q9H7U1

Source protein: Serine-rich coiled-coil domain-containing protein 2

Source gene: CCSER2

Class: DEG_APCC_DBOX_1

Location: 23:31

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7578

ASA_SCORE: 95.7111

COIL: 0.9058

CONS_SCORE: 0.6848

DSS_SCORE: 0.5723

HELIX: 0.0326

FCONS_SCORE: 0.96

RIG_SCORE: 0.71

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G33E	TCGA-AA-3811	COAD	TCGA	VRSTLQPMP	DEG_APCC_DBOX_1	0.2778
p.G33E	DO7962	COAD	ICGC	VRSTLQPMP	DEG_APCC_DBOX_1	0.2778
p.T26A	TCGA-AP-A1DK	UCEC	TCGA	VRSTLQPMP	DEG_APCC_DBOX_1	0.6028
p.T26A	DO42033	UCEC	ICGC	VRSTLQPMP	DEG_APCC_DBOX_1	0.6028
p.N37Y	TCGA-CM-6168	COAD	TCGA	VRSTLQPMP	DEG_APCC_DBOX_1	0.1667
p.N37Y	DO9602	COAD	ICGC	VRSTLQPMP	DEG_APCC_DBOX_1	0.1667
p.G33W	TCGA-D3-A2JO	SKCM	TCGA	VRSTLQPMP	DEG_APCC_DBOX_1	0.2778
p.G33W	DO47619	SKCM	ICGC	VRSTLQPMP	DEG_APCC_DBOX_1	0.2778
p.S22Y	TCGA-EE-A181	SKCM	TCGA	VRSTLQPMP	DEG_APCC_DBOX_1	0.3056
p.S22Y	DO37444	SKCM	ICGC	VRSTLQPMP	DEG_APCC_DBOX_1	0.3056
p.P35H	TCGA-EE-A2M7	SKCM	TCGA	VRSTLQPMP	DEG_APCC_DBOX_1	0.2222
p.P35H	DO37847	SKCM	ICGC	VRSTLQPMP	DEG_APCC_DBOX_1	0.2222
p.K21E	TCGA-EO-A22U	UCEC	TCGA	VRSTLQPMP	DEG_APCC_DBOX_1	0.2778
p.K21E	DO43755	UCEC	ICGC	VRSTLQPMP	DEG_APCC_DBOX_1	0.2778
p.N37H	TCGA-F5-6814	READ	TCGA	VRSTLQPMP	DEG_APCC_DBOX_1	0.1667
p.N37H	DO36556	READ	ICGC	VRSTLQPMP	DEG_APCC_DBOX_1	0.1667
p.K14T	TCGA-P3-A6SX	HNSC	TCGA	VRSTLQPMP	DEG_APCC_DBOX_1	0.1944
p.K14T	DO49051	HNSC	ICGC	VRSTLQPMP	DEG_APCC_DBOX_1	0.1944
p.G40E	DO220875	MELA	ICGC	VRSTLQPMP	DEG_APCC_DBOX_1	0.0833
p.G33A	SIDM01120	Other Solid Cancers	GDSC	VRSTLQPMP	DEG_APCC_DBOX_1	0.2778
p.G33A	ACH-002174	Lung Cancer	CCLE	VRSTLQPMP	DEG_APCC_DBOX_1	0.2778
p.G33A	NCI-H720	lung	COSMIC	VRSTLQPMP	DEG_APCC_DBOX_1	0.2778
p.R24K	SIDM00749	Non-Small Cell Lung Carcinoma	GDSC	VRSTLQPMP	DEG_APCC_DBOX_1	0.7237
p.R24K	ACH-000916	Lung Cancer	CCLE	VRSTLQPMP	DEG_APCC_DBOX_1	0.7237
p.R24K	NCI-H1573	lung	COSMIC	VRSTLQPMP	DEG_APCC_DBOX_1	0.7237
p.N37K	ACH-000971	Colon/Colorectal Cancer	CCLE	VRSTLQPMP	DEG_APCC_DBOX_1	0.1667
p.Y40C	ESO26	oesophagus	COSMIC	VRSTLQPMP	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H7U1	Serine-rich coiled-coil domain-containing protein 2	DEG_APCC_DBOX_1	23:31	VRSTLQPMP	APC,CDC20,FZR1	0.7578	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VRSTLQPMP

Degron related mutations and impact score

Drug responses associated with CCSER2 mutations

All proteins holding degron of VRSTLQPMP