DegronMD

Uniprot ID: Q2M3C7

Source protein: A-kinase anchor protein SPHKAP

Source gene: SPHKAP

Class: DEG_APCC_DBOX_1

Location: 1195:1203

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5616

ASA_SCORE: 75.8556

COIL: 0.1637

CONS_SCORE: 0.628

DSS_SCORE: 0.4036

HELIX: 0.8329

FCONS_SCORE: 1.0266

RIG_SCORE: 0.8561

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1209I	TCGA-17-Z031	LUAD	TCGA	YRYMLRDIE	DEG_APCC_DBOX_1	0.6111
p.S1209I	TCGA-29-1785	OV	TCGA	YRYMLRDIE	DEG_APCC_DBOX_1	0.6111
p.S1209I	DO31624	OV	ICGC	YRYMLRDIE	DEG_APCC_DBOX_1	0.6111
p.D1205E	TCGA-22-4594	LUSC	TCGA	YRYMLRDIE	DEG_APCC_DBOX_1	0.2778
p.D1205E	DO27476	LUSC	ICGC	YRYMLRDIE	DEG_APCC_DBOX_1	0.2778
p.E1203Q	TCGA-43-8118	LUSC	TCGA	YRYMLRDIE	DEG_APCC_DBOX_1	0.5633
p.E1203Q	DO45471	LUSC	ICGC	YRYMLRDIE	DEG_APCC_DBOX_1	0.5633
p.R1196K	TCGA-77-6842	LUSC	TCGA	YRYMLRDIE	DEG_APCC_DBOX_1	0.7237
p.R1196K	DO27413	LUSC	ICGC	YRYMLRDIE	DEG_APCC_DBOX_1	0.7237
p.M1198K	TCGA-AA-3819	COAD	TCGA	YRYMLRDIE	DEG_APCC_DBOX_1	0.6951
p.M1198K	DO10590	COAD	ICGC	YRYMLRDIE	DEG_APCC_DBOX_1	0.6951
p.A1210S	TCGA-CA-6716	COAD	TCGA	YRYMLRDIE	DEG_APCC_DBOX_1	0.1389
p.A1210S	DO9618	COAD	ICGC	YRYMLRDIE	DEG_APCC_DBOX_1	0.1389
p.R1204I	TCGA-EE-A2GC	SKCM	TCGA	YRYMLRDIE	DEG_APCC_DBOX_1	0.3056
p.R1204I	DO37839	SKCM	ICGC	YRYMLRDIE	DEG_APCC_DBOX_1	0.3056
p.E1203K	TCGA-F4-6856	COAD	TCGA	YRYMLRDIE	DEG_APCC_DBOX_1	0.591
p.E1203K	TCGA-GF-A6C9	SKCM	TCGA	YRYMLRDIE	DEG_APCC_DBOX_1	0.591
p.E1203K	DO218709	BRCA	ICGC	YRYMLRDIE	DEG_APCC_DBOX_1	0.591
p.E1203K	DO9114	COAD	ICGC	YRYMLRDIE	DEG_APCC_DBOX_1	0.591
p.E1203K	DO220857	MELA	ICGC	YRYMLRDIE	DEG_APCC_DBOX_1	0.591
p.E1203K	DO229453	SKCA	ICGC	YRYMLRDIE	DEG_APCC_DBOX_1	0.591
p.E1203K	DO51254	SKCM	ICGC	YRYMLRDIE	DEG_APCC_DBOX_1	0.591
p.E1203K	SIDM01113	Other Sarcomas	GDSC	YRYMLRDIE	DEG_APCC_DBOX_1	0.591
p.E1203K	ACH-000939	Sarcoma	CCLE	YRYMLRDIE	DEG_APCC_DBOX_1	0.591
p.E1203K	SK-UT-1	soft_tissue	COSMIC	YRYMLRDIE	DEG_APCC_DBOX_1	0.591
p.D1205G	DO7801	COAD	ICGC	YRYMLRDIE	DEG_APCC_DBOX_1	0.2778
p.R1207K	DO231091	LUSC	ICGC	YRYMLRDIE	DEG_APCC_DBOX_1	0.2222
p.R1207K	DO222843	MELA	ICGC	YRYMLRDIE	DEG_APCC_DBOX_1	0.2222
p.E1188D	DO222843	MELA	ICGC	YRYMLRDIE	DEG_APCC_DBOX_1	0.1389
p.S1185Y	DO232224	PBCA	ICGC	YRYMLRDIE	DEG_APCC_DBOX_1	0.0556
p.E1192K	SIDM00506	Small Cell Lung Carcinoma	GDSC	YRYMLRDIE	DEG_APCC_DBOX_1	0.25
p.E1192K	ACH-000508	Lung Cancer	CCLE	YRYMLRDIE	DEG_APCC_DBOX_1	0.25
p.E1192K	COR-L88	lung	COSMIC	YRYMLRDIE	DEG_APCC_DBOX_1	0.25
p.A1210V	SIDM00282	Colorectal Carcinoma	GDSC	YRYMLRDIE	DEG_APCC_DBOX_1	0.1389
p.A1210V	ACH-000998	Colon/Colorectal Cancer	CCLE	YRYMLRDIE	DEG_APCC_DBOX_1	0.1389
p.A1210V	CW-2	large_intestine	COSMIC	YRYMLRDIE	DEG_APCC_DBOX_1	0.1389
p.L1199P	SIDM01043	Other Sarcomas	GDSC	YRYMLRDIE	DEG_APCC_DBOX_1	0.7582
p.L1199P	ACH-000913	Endometrial/Uterine Cancer	CCLE	YRYMLRDIE	DEG_APCC_DBOX_1	0.7582
p.L1199P	ESS-1	endometrium	COSMIC	YRYMLRDIE	DEG_APCC_DBOX_1	0.7582
p.S1211F	ACH-002396	Bone Cancer	CCLE	YRYMLRDIE	DEG_APCC_DBOX_1	0.5556
p.S1211F	Sarc9371	bone	COSMIC	YRYMLRDIE	DEG_APCC_DBOX_1	0.5556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: YRYMLRDIE

Degron related mutations and impact score

Drug responses associated with SPHKAP mutations

All proteins holding degron of YRYMLRDIE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q2M3C7	A-kinase anchor protein SPHKAP	DEG_APCC_DBOX_1	1195:1203	YRYMLRDIE	APC,CDC20,FZR1	0.5616	More...