DegronMD

Uniprot ID: Q2M3C7

Source protein: A-kinase anchor protein SPHKAP

Source gene: SPHKAP

Class: DEG_SPOP_SBC_1

Location: 826:830

E3 ligase: SPOP

DEGRON score: 0.9894

ASA_SCORE: 73.26

COIL: 0.8206

CONS_SCORE: 0.5613

DSS_SCORE: 0.5745

HELIX: 0.0568

FCONS_SCORE: 1.1693

RIG_SCORE: 0.665

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G837E	TCGA-D9-A6EC	SKCM	TCGA	ATTSS	DEG_SPOP_SBC_1	0.1389
p.G837E	TCGA-Z2-A8RT	SKCM	TCGA	ATTSS	DEG_SPOP_SBC_1	0.1389
p.G837E	DO50291	SKCM	ICGC	ATTSS	DEG_SPOP_SBC_1	0.1389
p.G837E	DO51301	SKCM	ICGC	ATTSS	DEG_SPOP_SBC_1	0.1389
p.T827K	TCGA-DX-A6BK	SARC	TCGA	ATTSS	DEG_SPOP_SBC_1	0.6195
p.T827K	DO220001	SARC	ICGC	ATTSS	DEG_SPOP_SBC_1	0.6195
p.E832K	TCGA-EB-A299	SKCM	TCGA	ATTSS	DEG_SPOP_SBC_1	0.2778
p.E832K	TCGA-EB-A4IS	SKCM	TCGA	ATTSS	DEG_SPOP_SBC_1	0.2778
p.E832K	TCGA-FR-A3YO	SKCM	TCGA	ATTSS	DEG_SPOP_SBC_1	0.2778
p.E832K	DO222753	MELA	ICGC	ATTSS	DEG_SPOP_SBC_1	0.2778
p.E832K	DO222875	MELA	ICGC	ATTSS	DEG_SPOP_SBC_1	0.2778
p.E832K	DO47281	SKCM	ICGC	ATTSS	DEG_SPOP_SBC_1	0.2778
p.E832K	DO37794	SKCM	ICGC	ATTSS	DEG_SPOP_SBC_1	0.2778
p.E832K	DO37419	SKCM	ICGC	ATTSS	DEG_SPOP_SBC_1	0.2778
p.S830F	TCGA-EE-A29A	SKCM	TCGA	ATTSS	DEG_SPOP_SBC_1	0.7982
p.S830F	DO37416	SKCM	ICGC	ATTSS	DEG_SPOP_SBC_1	0.7982
p.S829F	TCGA-W3-A824	SKCM	TCGA	ATTSS	DEG_SPOP_SBC_1	0.7982
p.S829F	DO51271	SKCM	ICGC	ATTSS	DEG_SPOP_SBC_1	0.7982
p.R816H	TCGA-ZG-A8QY	PRAD	TCGA	ATTSS	DEG_SPOP_SBC_1	0.0556
p.R816H	DO51449	PRAD	ICGC	ATTSS	DEG_SPOP_SBC_1	0.0556
p.Y834C	DO229098	LMS	ICGC	ATTSS	DEG_SPOP_SBC_1	0.2222
p.H818Y	SIDM01183	Other Solid Cancers	GDSC	ATTSS	DEG_SPOP_SBC_1	0.1111
p.H818Y	ACH-001417	Lung Cancer	CCLE	ATTSS	DEG_SPOP_SBC_1	0.1111
p.H818Y	UMC-11	lung	COSMIC	ATTSS	DEG_SPOP_SBC_1	0.1111
p.G840V	SIDM01162	Kidney Carcinoma	GDSC	ATTSS	DEG_SPOP_SBC_1	0.0556
p.G840V	ACH-001398	Kidney Cancer	CCLE	ATTSS	DEG_SPOP_SBC_1	0.0556
p.G840V	SW156	kidney	COSMIC	ATTSS	DEG_SPOP_SBC_1	0.0556
p.T827A	SIDM01680	Non-Cancerous	GDSC	ATTSS	DEG_SPOP_SBC_1	0.6028
p.T827A	ACH-002364	Non-Cancerous	CCLE	ATTSS	DEG_SPOP_SBC_1	0.6028

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P28715	DNA excision repair protein ERCC-5	DEG_SPOP_SBC_1	1143:1147	ATTSS	SPOP	0.9952	More...
P43694	Transcription factor GATA-4	DEG_SPOP_SBC_1	353:357	ATTSS	SPOP	0.857	More...
P49790	Nuclear pore complex protein Nup153	DEG_SPOP_SBC_1	1261:1265	ATTSS	SPOP	0.9691	More...
P78364	Polyhomeotic-like protein 1	DEG_SPOP_SBC_1	609:613	ATTSS	SPOP	0.9204	More...
Q2M3C7	A-kinase anchor protein SPHKAP	DEG_SPOP_SBC_1	826:830	ATTSS	SPOP	0.9894	More...
Q58EX2	Protein sidekick-2	DEG_SPOP_SBC_1	1210:1214	ATTSS	SPOP	0.6255	More...
Q6PIW4	Fidgetin-like protein 1	DEG_SPOP_SBC_1	531:535	ATTSS	SPOP	0.5474	More...
Q6UXF1	Transmembrane protein 108	DEG_SPOP_SBC_1	123:127	ATTSS	SPOP	0.9883	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	7254:7258	ATTSS	SPOP	0.9689	More...
Q8NBF1	Zinc finger protein GLIS1	DEG_SPOP_SBC_1	433:437	ATTSS	SPOP	0.9971	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	508:512	ATTSS	SPOP	0.9959	More...
Q92537	Sushi domain-containing protein 6	DEG_SPOP_SBC_1	255:259	ATTSS	SPOP	0.9991	More...
Q96HC4	PDZ and LIM domain protein 5	DEG_SPOP_SBC_1	155:159	ATTSS	SPOP	0.9493	More...
Q9ULI3	Protein HEG homolog 1	DEG_SPOP_SBC_1	366:370	ATTSS	SPOP	0.9751	More...
Q9UPP5	AP2-interacting clathrin-endocytosis protein	DEG_SPOP_SBC_1	742:746	ATTSS	SPOP	0.8709	More...
Q2M2H8	Probable maltase-glucoamylase 2	DEG_SPOP_SBC_1	2121:2125	ATTSS	SPOP	0.9126	More...
Q8IX06	Putative exonuclease GOR	DEG_SPOP_SBC_1	261:265	ATTSS	SPOP	0.9965	More...
E2RYF6	Mucin-22	DEG_SPOP_SBC_1	1415:1419	ATTSS	SPOP	0.9991	More...
Q2KHR3	Glutamine and serine-rich protein 1	DEG_SPOP_SBC_1	1281:1285	ATTSS	SPOP	0.9971	More...
Q5BKX6	Solute carrier family 45 member 4	DEG_SPOP_SBC_1	476:480	ATTSS	SPOP	0.674	More...
A6NGY3	Uncharacterized protein C5orf52	DEG_SPOP_SBC_1	25:29	ATTSS	SPOP	0.8442	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ATTSS

Degron related mutations and impact score

Drug responses associated with SPHKAP mutations

All proteins holding degron of ATTSS