DegronMD

Uniprot ID: Q8NBF1

Source protein: Zinc finger protein GLIS1

Source gene: GLIS1

Class: DEG_SPOP_SBC_1

Location: 433:437

E3 ligase: SPOP

DEGRON score: 0.9971

ASA_SCORE: 70.2

COIL: 0.9224

CONS_SCORE: 0.3325

DSS_SCORE: 0.6543

HELIX: 0.0474

FCONS_SCORE: 1.1011

RIG_SCORE: 0.5469

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P443T	TCGA-78-7154	LUAD	TCGA	ATTSS	DEG_SPOP_SBC_1	0.1667
p.P443T	DO24070	LUAD	ICGC	ATTSS	DEG_SPOP_SBC_1	0.1667
p.V424L	TCGA-EO-A22X	UCEC	TCGA	ATTSS	DEG_SPOP_SBC_1	0.0833
p.V424L	DO43907	UCEC	ICGC	ATTSS	DEG_SPOP_SBC_1	0.0833
p.L441V	TCGA-LN-A49M	ESCA	TCGA	ATTSS	DEG_SPOP_SBC_1	0.2222
p.H428Y	TCGA-W3-AA1V	SKCM	TCGA	ATTSS	DEG_SPOP_SBC_1	0.1944
p.H428Y	DO51276	SKCM	ICGC	ATTSS	DEG_SPOP_SBC_1	0.1944
p.H439Q	DO233137	GACA	ICGC	ATTSS	DEG_SPOP_SBC_1	0.2778
p.D423E	DO228985	LICA	ICGC	ATTSS	DEG_SPOP_SBC_1	0.0556
p.T434S	DO230525	LUSC	ICGC	ATTSS	DEG_SPOP_SBC_1	0.6005
p.D423N	DO230993	LUSC	ICGC	ATTSS	DEG_SPOP_SBC_1	0.0556
p.T435I	DO220875	MELA	ICGC	ATTSS	DEG_SPOP_SBC_1	0.7078
p.P430L	SIDM00084	Glioblastoma	GDSC	ATTSS	DEG_SPOP_SBC_1	0.25
p.P430L	SIDM00629	Breast Carcinoma	GDSC	ATTSS	DEG_SPOP_SBC_1	0.25
p.P430L	SIDM00798	Rhabdomyosarcoma	GDSC	ATTSS	DEG_SPOP_SBC_1	0.25
p.P430L	SIDM00264	Ewing's Sarcoma	GDSC	ATTSS	DEG_SPOP_SBC_1	0.25
p.P430L	SIDM00013	Melanoma	GDSC	ATTSS	DEG_SPOP_SBC_1	0.25
p.P430L	SIDM00092	Ovarian Carcinoma	GDSC	ATTSS	DEG_SPOP_SBC_1	0.25
p.P430L	SIDM00049	Colorectal Carcinoma	GDSC	ATTSS	DEG_SPOP_SBC_1	0.25
p.P430L	SIDM00132	Pancreatic Carcinoma	GDSC	ATTSS	DEG_SPOP_SBC_1	0.25
p.P430L	SIDM01648	Non-Cancerous	GDSC	ATTSS	DEG_SPOP_SBC_1	0.25
p.P430L	SIDM00975	Melanoma	GDSC	ATTSS	DEG_SPOP_SBC_1	0.25
p.P430L	SIDM01086	B-Lymphoblastic Leukemia	GDSC	ATTSS	DEG_SPOP_SBC_1	0.25
p.P430L	SIDM01323	Oral Cavity Carcinoma	GDSC	ATTSS	DEG_SPOP_SBC_1	0.25
p.H440N	SIDM00672	Hepatocellular Carcinoma	GDSC	ATTSS	DEG_SPOP_SBC_1	0.25
p.H440N	ACH-000625	Liver Cancer	CCLE	ATTSS	DEG_SPOP_SBC_1	0.25
p.H440N	Hep_3B2_1-7	NS	COSMIC	ATTSS	DEG_SPOP_SBC_1	0.25
p.P425L	SIDM00687	Gastric Carcinoma	GDSC	ATTSS	DEG_SPOP_SBC_1	0.1111
p.P425L	ACH-000793	Gastric Cancer	CCLE	ATTSS	DEG_SPOP_SBC_1	0.1111
p.P425L	KATOIII	stomach	COSMIC	ATTSS	DEG_SPOP_SBC_1	0.1111
p.A447V	SIDM00494	Non-Small Cell Lung Carcinoma	GDSC	ATTSS	DEG_SPOP_SBC_1	0.0556
p.A447V	ACH-000528	Lung Cancer	CCLE	ATTSS	DEG_SPOP_SBC_1	0.0556
p.A447V	ABC-1	lung	COSMIC	ATTSS	DEG_SPOP_SBC_1	0.0556
p.E442D	CS1	bone	COSMIC	ATTSS	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P28715	DNA excision repair protein ERCC-5	DEG_SPOP_SBC_1	1143:1147	ATTSS	SPOP	0.9952	More...
P43694	Transcription factor GATA-4	DEG_SPOP_SBC_1	353:357	ATTSS	SPOP	0.857	More...
P49790	Nuclear pore complex protein Nup153	DEG_SPOP_SBC_1	1261:1265	ATTSS	SPOP	0.9691	More...
P78364	Polyhomeotic-like protein 1	DEG_SPOP_SBC_1	609:613	ATTSS	SPOP	0.9204	More...
Q2M3C7	A-kinase anchor protein SPHKAP	DEG_SPOP_SBC_1	826:830	ATTSS	SPOP	0.9894	More...
Q58EX2	Protein sidekick-2	DEG_SPOP_SBC_1	1210:1214	ATTSS	SPOP	0.6255	More...
Q6PIW4	Fidgetin-like protein 1	DEG_SPOP_SBC_1	531:535	ATTSS	SPOP	0.5474	More...
Q6UXF1	Transmembrane protein 108	DEG_SPOP_SBC_1	123:127	ATTSS	SPOP	0.9883	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	7254:7258	ATTSS	SPOP	0.9689	More...
Q8NBF1	Zinc finger protein GLIS1	DEG_SPOP_SBC_1	433:437	ATTSS	SPOP	0.9971	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	508:512	ATTSS	SPOP	0.9959	More...
Q92537	Sushi domain-containing protein 6	DEG_SPOP_SBC_1	255:259	ATTSS	SPOP	0.9991	More...
Q96HC4	PDZ and LIM domain protein 5	DEG_SPOP_SBC_1	155:159	ATTSS	SPOP	0.9493	More...
Q9ULI3	Protein HEG homolog 1	DEG_SPOP_SBC_1	366:370	ATTSS	SPOP	0.9751	More...
Q9UPP5	AP2-interacting clathrin-endocytosis protein	DEG_SPOP_SBC_1	742:746	ATTSS	SPOP	0.8709	More...
Q2M2H8	Probable maltase-glucoamylase 2	DEG_SPOP_SBC_1	2121:2125	ATTSS	SPOP	0.9126	More...
Q8IX06	Putative exonuclease GOR	DEG_SPOP_SBC_1	261:265	ATTSS	SPOP	0.9965	More...
E2RYF6	Mucin-22	DEG_SPOP_SBC_1	1415:1419	ATTSS	SPOP	0.9991	More...
Q2KHR3	Glutamine and serine-rich protein 1	DEG_SPOP_SBC_1	1281:1285	ATTSS	SPOP	0.9971	More...
Q5BKX6	Solute carrier family 45 member 4	DEG_SPOP_SBC_1	476:480	ATTSS	SPOP	0.674	More...
A6NGY3	Uncharacterized protein C5orf52	DEG_SPOP_SBC_1	25:29	ATTSS	SPOP	0.8442	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ATTSS

Degron related mutations and impact score

Drug responses associated with GLIS1 mutations

All proteins holding degron of ATTSS