DegronMD - Q58EX2(SDK2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V1518L	TCGA-53-A4EZ	LUAD	TCGA	PHTTT	DEG_SPOP_SBC_1	1512:1516	Mutation rewiring degron network	0.2778
p.V1518L	TCGA-DX-A7EF	SARC	TCGA	PHTTT	DEG_SPOP_SBC_1	1512:1516	Mutation rewiring degron network	0.2778
p.V1518L	DO45319	LUAD	ICGC	PHTTT	DEG_SPOP_SBC_1	1512:1516	Mutation rewiring degron network	0.2778
p.V1518L	DO220021	SARC	ICGC	PHTTT	DEG_SPOP_SBC_1	1512:1516	Mutation rewiring degron network	0.2778
p.R1521Q	TCGA-96-7544	LUSC	TCGA	PHTTT	DEG_SPOP_SBC_1	1512:1516	Mutation rewiring degron network	0.1944
p.R1521Q	DO26425	LUSC	ICGC	PHTTT	DEG_SPOP_SBC_1	1512:1516	Mutation rewiring degron network	0.1944
p.E2046D	TCGA-A5-A0G2	UCEC	TCGA	AESSS	DEG_SPOP_SBC_1	2039:2043	Mutation rewiring degron network	0.25
p.E2046D	DO41235	UCEC	ICGC	AESSS	DEG_SPOP_SBC_1	2039:2043	Mutation rewiring degron network	0.25
p.R451H	TCGA-A5-A0G2	UCEC	TCGA	PRFTPLES	DEG_SCF_FBW7_1	450:457	Mutation altering degron motif	0.7133
p.R451H	DO41235	UCEC	ICGC	PRFTPLES	DEG_SCF_FBW7_1	450:457	Mutation altering degron motif	0.7133
p.G1202S	TCGA-A6-6781	COAD	TCGA	ATTSS	DEG_SPOP_SBC_1	1210:1214	Mutation rewiring degron network	0.1111
p.G1202S	DO8447	COAD	ICGC	ATTSS	DEG_SPOP_SBC_1	1210:1214	Mutation rewiring degron network	0.1111
p.L1508I	TCGA-AA-3864	COAD	TCGA	PHTTT	DEG_SPOP_SBC_1	1512:1516	Mutation rewiring degron network	0.2222
p.L1508I	DO8490	COAD	ICGC	PHTTT	DEG_SPOP_SBC_1	1512:1516	Mutation rewiring degron network	0.2222
p.R440C	TCGA-AA-A01R	COAD	TCGA	PRFTPLES	DEG_SCF_FBW7_1	450:457	Mutation rewiring degron network	0.0556
p.R440C	DO7934	COAD	ICGC	PRFTPLES	DEG_SCF_FBW7_1	450:457	Mutation rewiring degron network	0.0556
p.H2024N	TCGA-AP-A059	UCEC	TCGA	NGLYTRSP	CBL_PTK	2008:2015	Mutation rewiring degron network	0.0833
p.H2024N	DO41361	UCEC	ICGC	NGLYTRSP	CBL_PTK	2008:2015	Mutation rewiring degron network	0.0833
p.A2039V	TCGA-AP-A1DK	UCEC	TCGA	AESSS	DEG_SPOP_SBC_1	2039:2043	Mutation altering degron motif	0.5825
p.A2039V	DO42033	UCEC	ICGC	AESSS	DEG_SPOP_SBC_1	2039:2043	Mutation altering degron motif	0.5825
p.R2006Q	TCGA-AX-A0J0	UCEC	TCGA	NGLYTRSP	CBL_PTK	2008:2015	Mutation rewiring degron network	0.2778
p.R2006Q	DO41133	UCEC	ICGC	NGLYTRSP	CBL_PTK	2008:2015	Mutation rewiring degron network	0.2778
p.T1511M	TCGA-BK-A26L	UCEC	TCGA	PHTTT	DEG_SPOP_SBC_1	1512:1516	Mutation rewiring degron network	0.3056
p.T1511M	DO38899	THCA	ICGC	PHTTT	DEG_SPOP_SBC_1	1512:1516	Mutation rewiring degron network	0.3056
p.T1511M	DO41355	UCEC	ICGC	PHTTT	DEG_SPOP_SBC_1	1512:1516	Mutation rewiring degron network	0.3056
p.L2036F	TCGA-BP-5169	KIRC	TCGA	AESSS	DEG_SPOP_SBC_1	2039:2043	Mutation rewiring degron network	0.25
p.L2036F	DO18075	KIRC	ICGC	AESSS	DEG_SPOP_SBC_1	2039:2043	Mutation rewiring degron network	0.25
p.E2040K	TCGA-CV-A6K2	HNSC	TCGA	AESSS	DEG_SPOP_SBC_1	2039:2043	Mutation altering degron motif	0.591
p.E2040K	DO52079	HNSC	ICGC	AESSS	DEG_SPOP_SBC_1	2039:2043	Mutation altering degron motif	0.591
p.S457L	TCGA-EE-A2MS	SKCM	TCGA	PRFTPLES	DEG_SCF_FBW7_1	450:457	Mutation altering degron motif	0.7667
p.S457L	DO233634	GACA	ICGC	PRFTPLES	DEG_SCF_FBW7_1	450:457	Mutation altering degron motif	0.7667
p.S457L	DO37567	SKCM	ICGC	PRFTPLES	DEG_SCF_FBW7_1	450:457	Mutation altering degron motif	0.7667
p.E1503K	TCGA-EE-A3AE	SKCM	TCGA	PHTTT	DEG_SPOP_SBC_1	1512:1516	Mutation rewiring degron network	0.0833
p.E1503K	DO37802	SKCM	ICGC	PHTTT	DEG_SPOP_SBC_1	1512:1516	Mutation rewiring degron network	0.0833
p.S1215N	TCGA-EO-A3KX	UCEC	TCGA	ATTSS	DEG_SPOP_SBC_1	1210:1214	Mutation rewiring degron network	0.3056
p.S1215N	DO219774	UCEC	ICGC	ATTSS	DEG_SPOP_SBC_1	1210:1214	Mutation rewiring degron network	0.3056
p.W1220R	TCGA-G2-A3IB	BLCA	TCGA	ATTSS	DEG_SPOP_SBC_1	1210:1214	Mutation rewiring degron network	0.1667
p.W1220R	DO512	BLCA	ICGC	ATTSS	DEG_SPOP_SBC_1	1210:1214	Mutation rewiring degron network	0.1667
p.I2037V	TCGA-L5-A8NM	ESCA	TCGA	AESSS	DEG_SPOP_SBC_1	2039:2043	Mutation rewiring degron network	0.2778
p.K2007N	TCGA-N8-A4PL	UCS	TCGA	NGLYTRSP	CBL_PTK	2008:2015	Mutation rewiring degron network	0.3056
p.V1510M	DO234155	ESAD	ICGC	PHTTT	DEG_SPOP_SBC_1	1512:1516	Mutation rewiring degron network	0.2778
p.P1224L	DO234324	ESAD	ICGC	ATTSS	DEG_SPOP_SBC_1	1210:1214	Mutation rewiring degron network	0.0556
p.V1518M	DO233259	GACA	ICGC	PHTTT	DEG_SPOP_SBC_1	1512:1516	Mutation rewiring degron network	0.2778
p.V1518M	SIDM00611	Kidney Carcinoma	GDSC	PHTTT	DEG_SPOP_SBC_1	1512:1516	Mutation rewiring degron network	0.2778
p.V1518M	SIDM00354	Squamous Cell Lung Carcinoma	GDSC	PHTTT	DEG_SPOP_SBC_1	1512:1516	Mutation rewiring degron network	0.2778
p.V1518M	SIDM00238	Ovarian Carcinoma	GDSC	PHTTT	DEG_SPOP_SBC_1	1512:1516	Mutation rewiring degron network	0.2778
p.V1518M	SIDM00487	Colorectal Carcinoma	GDSC	PHTTT	DEG_SPOP_SBC_1	1512:1516	Mutation rewiring degron network	0.2778
p.V1518M	SIDM00380	Acute Myeloid Leukemia	GDSC	PHTTT	DEG_SPOP_SBC_1	1512:1516	Mutation rewiring degron network	0.2778
p.V1518M	SIDM01575	Plasma Cell Myeloma	GDSC	PHTTT	DEG_SPOP_SBC_1	1512:1516	Mutation rewiring degron network	0.2778
p.V1518M	CCK-81	large intestine	COSMIC	PHTTT	DEG_SPOP_SBC_1	1512:1516	Mutation rewiring degron network	0.2778
p.V1518M	RERF-LC-Sq1	lung	COSMIC	PHTTT	DEG_SPOP_SBC_1	1512:1516	Mutation rewiring degron network	0.2778
p.V1518M	OVK-18	ovary	COSMIC	PHTTT	DEG_SPOP_SBC_1	1512:1516	Mutation rewiring degron network	0.2778
p.V1518M	KMRC-1	kidney	COSMIC	PHTTT	DEG_SPOP_SBC_1	1512:1516	Mutation rewiring degron network	0.2778
p.V1518M	SKM-1	haematopoietic and lymphoid tissue	COSMIC	PHTTT	DEG_SPOP_SBC_1	1512:1516	Mutation rewiring degron network	0.2778
p.S2042R	DO229018	LICA	ICGC	AESSS	DEG_SPOP_SBC_1	2039:2043	Mutation altering degron motif	0.7427
p.L1209M	DO229031	LICA	ICGC	ATTSS	DEG_SPOP_SBC_1	1210:1214	Mutation rewiring degron network	0.3056
p.T1511K	DO229037	LICA	ICGC	PHTTT	DEG_SPOP_SBC_1	1512:1516	Mutation rewiring degron network	0.3056
p.S2019R	DO229009	LICA	ICGC	NGLYTRSP	CBL_PTK	2008:2015	Mutation rewiring degron network	0.2222
p.P1203T	DO229009	LICA	ICGC	ATTSS	DEG_SPOP_SBC_1	1210:1214	Mutation rewiring degron network	0.1389
p.S1221R	DO46374	OV	ICGC	ATTSS	DEG_SPOP_SBC_1	1210:1214	Mutation blocking phosphorylation signal	0.5833
p.P2015A	DO51061	PRAD	ICGC	NGLYTRSP	CBL_PTK	2008:2015	Mutation altering degron motif	0.7503
p.G1202D	SIDM02059	Colorectal Carcinoma	GDSC	ATTSS	DEG_SPOP_SBC_1	1210:1214	Mutation rewiring degron network	0.1111
p.L461H	SIDM00541	Colorectal Carcinoma	GDSC	PRFTPLES	DEG_SCF_FBW7_1	450:457	Mutation rewiring degron network	0.2222
p.L461H	ACH-000926	Colon/Colorectal Cancer	CCLE	PRFTPLES	DEG_SCF_FBW7_1	450:457	Mutation rewiring degron network	0.2222
p.L461H	HT55	large intestine	COSMIC	PRFTPLES	DEG_SCF_FBW7_1	450:457	Mutation rewiring degron network	0.2222
p.T2045M	SIDM01197	Colorectal Carcinoma	GDSC	AESSS	DEG_SPOP_SBC_1	2039:2043	Mutation blocking phosphorylation signal	0.7222
p.T2045M	SIDM00015	Esophageal Squamous Cell Carcinoma	GDSC	AESSS	DEG_SPOP_SBC_1	2039:2043	Mutation blocking phosphorylation signal	0.7222
p.T2045M	SNU-C1	large intestine	COSMIC	AESSS	DEG_SPOP_SBC_1	2039:2043	Mutation blocking phosphorylation signal	0.7222
p.S1509F	SIDM01175	Other Sarcomas	GDSC	PHTTT	DEG_SPOP_SBC_1	1512:1516	Mutation rewiring degron network	0.25
p.S1509F	ACH-002309	Sarcoma	CCLE	PHTTT	DEG_SPOP_SBC_1	1512:1516	Mutation rewiring degron network	0.25
p.S1509F	SW684	soft tissue	COSMIC	PHTTT	DEG_SPOP_SBC_1	1512:1516	Mutation rewiring degron network	0.25
p.H1513Q	SIDM00348	Esophageal Squamous Cell Carcinoma	GDSC	PHTTT	DEG_SPOP_SBC_1	1512:1516	Mutation altering degron motif	0.647
p.H1513Q	ACH-000488	Esophageal Cancer	CCLE	PHTTT	DEG_SPOP_SBC_1	1512:1516	Mutation altering degron motif	0.647
p.H1513Q	TE-11	oesophagus	COSMIC	PHTTT	DEG_SPOP_SBC_1	1512:1516	Mutation altering degron motif	0.647
p.R440H	SIDM00537	Colorectal Carcinoma	GDSC	PRFTPLES	DEG_SCF_FBW7_1	450:457	Mutation rewiring degron network	0.0556
p.R440H	ACH-000982	Colon/Colorectal Cancer	CCLE	PRFTPLES	DEG_SCF_FBW7_1	450:457	Mutation rewiring degron network	0.0556
p.R440H	ACH-001345	Colon/Colorectal Cancer	CCLE	PRFTPLES	DEG_SCF_FBW7_1	450:457	Mutation rewiring degron network	0.0556
p.R440H	GP5d	large intestine	COSMIC	PRFTPLES	DEG_SCF_FBW7_1	450:457	Mutation rewiring degron network	0.0556
p.G2009S	SIDM00380	Acute Myeloid Leukemia	GDSC	NGLYTRSP	CBL_PTK	2008:2015	Mutation altering degron motif	0.5882
p.G2009S	ACH-000373	Leukemia	CCLE	NGLYTRSP	CBL_PTK	2008:2015	Mutation altering degron motif	0.5882
p.G2009S	SKM-1	haematopoietic and lymphoid tissue	COSMIC	NGLYTRSP	CBL_PTK	2008:2015	Mutation altering degron motif	0.5882
p.V2030I	SIDM00579	Neuroblastoma	GDSC	AESSS	DEG_SPOP_SBC_1	2039:2043	Mutation rewiring degron network	0.0833
p.V2030I	ACH-002277	Neuroblastoma	CCLE	AESSS	DEG_SPOP_SBC_1	2039:2043	Mutation rewiring degron network	0.0833
p.V2030I	NB(TU)1-10	autonomic ganglia	COSMIC	AESSS	DEG_SPOP_SBC_1	2039:2043	Mutation rewiring degron network	0.0833
p.E1222K	SIDM00982	Glioblastoma	GDSC	ATTSS	DEG_SPOP_SBC_1	1210:1214	Mutation rewiring degron network	0.1111
p.E1222K	ACH-000323	Brain Cancer	CCLE	ATTSS	DEG_SPOP_SBC_1	1210:1214	Mutation rewiring degron network	0.1111
p.E1222K	42-MG-BA	central nervous system	COSMIC	ATTSS	DEG_SPOP_SBC_1	1210:1214	Mutation rewiring degron network	0.1111
p.P1525L	ACH-000435	Endometrial/Uterine Cancer	CCLE	PHTTT	DEG_SPOP_SBC_1	1512:1516	Mutation rewiring degron network	0.0833
p.P2015S	ACH-000937	Leukemia	CCLE	NGLYTRSP	CBL_PTK	2008:2015	Mutation altering degron motif	0.6752
p.S1509Y	ACH-001557	Lung Cancer	CCLE	PHTTT	DEG_SPOP_SBC_1	1512:1516	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SDK2

UniProt ID: Q58EX2

Entrez ID: 54549

Protein name: Protein sidekick-2

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SDK2 in