DegronMD

Uniprot ID: Q58EX2

Source protein: Protein sidekick-2

Source gene: SDK2

Class: DEG_SPOP_SBC_1

Location: 1512:1516

E3 ligase: SPOP

DEGRON score: 0.9437

ASA_SCORE: 69.48

COIL: 0.7132

CONS_SCORE: 0.5239

DSS_SCORE: 0.3289

HELIX: 0.009

FCONS_SCORE: 1.0189

RIG_SCORE: 0.7798

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V1518L	TCGA-53-A4EZ	LUAD	TCGA	PHTTT	DEG_SPOP_SBC_1	0.2778
p.V1518L	TCGA-DX-A7EF	SARC	TCGA	PHTTT	DEG_SPOP_SBC_1	0.2778
p.V1518L	DO45319	LUAD	ICGC	PHTTT	DEG_SPOP_SBC_1	0.2778
p.V1518L	DO220021	SARC	ICGC	PHTTT	DEG_SPOP_SBC_1	0.2778
p.R1521Q	TCGA-96-7544	LUSC	TCGA	PHTTT	DEG_SPOP_SBC_1	0.1944
p.R1521Q	DO26425	LUSC	ICGC	PHTTT	DEG_SPOP_SBC_1	0.1944
p.L1508I	TCGA-AA-3864	COAD	TCGA	PHTTT	DEG_SPOP_SBC_1	0.2222
p.L1508I	DO8490	COAD	ICGC	PHTTT	DEG_SPOP_SBC_1	0.2222
p.T1511M	TCGA-BK-A26L	UCEC	TCGA	PHTTT	DEG_SPOP_SBC_1	0.3056
p.T1511M	DO38899	THCA	ICGC	PHTTT	DEG_SPOP_SBC_1	0.3056
p.T1511M	DO41355	UCEC	ICGC	PHTTT	DEG_SPOP_SBC_1	0.3056
p.E1503K	TCGA-EE-A3AE	SKCM	TCGA	PHTTT	DEG_SPOP_SBC_1	0.0833
p.E1503K	DO37802	SKCM	ICGC	PHTTT	DEG_SPOP_SBC_1	0.0833
p.V1510M	DO234155	ESAD	ICGC	PHTTT	DEG_SPOP_SBC_1	0.2778
p.V1518M	DO233259	GACA	ICGC	PHTTT	DEG_SPOP_SBC_1	0.2778
p.V1518M	SIDM00611	Kidney Carcinoma	GDSC	PHTTT	DEG_SPOP_SBC_1	0.2778
p.V1518M	SIDM00354	Squamous Cell Lung Carcinoma	GDSC	PHTTT	DEG_SPOP_SBC_1	0.2778
p.V1518M	SIDM00238	Ovarian Carcinoma	GDSC	PHTTT	DEG_SPOP_SBC_1	0.2778
p.V1518M	SIDM00487	Colorectal Carcinoma	GDSC	PHTTT	DEG_SPOP_SBC_1	0.2778
p.V1518M	SIDM00380	Acute Myeloid Leukemia	GDSC	PHTTT	DEG_SPOP_SBC_1	0.2778
p.V1518M	SIDM01575	Plasma Cell Myeloma	GDSC	PHTTT	DEG_SPOP_SBC_1	0.2778
p.V1518M	CCK-81	large_intestine	COSMIC	PHTTT	DEG_SPOP_SBC_1	0.2778
p.V1518M	RERF-LC-Sq1	lung	COSMIC	PHTTT	DEG_SPOP_SBC_1	0.2778
p.V1518M	OVK-18	ovary	COSMIC	PHTTT	DEG_SPOP_SBC_1	0.2778
p.V1518M	KMRC-1	kidney	COSMIC	PHTTT	DEG_SPOP_SBC_1	0.2778
p.V1518M	SKM-1	haematopoietic_and_lymphoid_tissue	COSMIC	PHTTT	DEG_SPOP_SBC_1	0.2778
p.T1511K	DO229037	LICA	ICGC	PHTTT	DEG_SPOP_SBC_1	0.3056
p.S1509F	SIDM01175	Other Sarcomas	GDSC	PHTTT	DEG_SPOP_SBC_1	0.25
p.S1509F	ACH-002309	Sarcoma	CCLE	PHTTT	DEG_SPOP_SBC_1	0.25
p.S1509F	SW684	soft_tissue	COSMIC	PHTTT	DEG_SPOP_SBC_1	0.25
p.H1513Q	SIDM00348	Esophageal Squamous Cell Carcinoma	GDSC	PHTTT	DEG_SPOP_SBC_1	0.647
p.H1513Q	ACH-000488	Esophageal Cancer	CCLE	PHTTT	DEG_SPOP_SBC_1	0.647
p.H1513Q	TE-11	oesophagus	COSMIC	PHTTT	DEG_SPOP_SBC_1	0.647
p.P1525L	ACH-000435	Endometrial/Uterine Cancer	CCLE	PHTTT	DEG_SPOP_SBC_1	0.0833
p.S1509Y	ACH-001557	Lung Cancer	CCLE	PHTTT	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q58EX2	Protein sidekick-2	DEG_SPOP_SBC_1	1512:1516	PHTTT	SPOP	0.9437	More...
Q9BY11	Protein kinase C and casein kinase substrate in neurons protein 1	DEG_SPOP_SBC_1	310:314	PHTTT	SPOP	0.946	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PHTTT

Degron related mutations and impact score

Drug responses associated with SDK2 mutations

All proteins holding degron of PHTTT