DegronMD - Q9BY11(PACSIN1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P310H	TCGA-A5-A0G1	UCEC	TCGA	PHTTT	DEG_SPOP_SBC_1	310:314	Mutation altering degron motif	0.7694
p.P310H	DO42472	UCEC	ICGC	PHTTT	DEG_SPOP_SBC_1	310:314	Mutation altering degron motif	0.7694
p.G345S	TCGA-BR-A4IY	STAD	TCGA	VESTS	DEG_SPOP_SBC_1	335:339	Mutation rewiring degron network	0.1667
p.G345S	DO228609	LICA	ICGC	VESTS	DEG_SPOP_SBC_1	335:339	Mutation rewiring degron network	0.1667
p.G345S	DO38396	STAD	ICGC	VESTS	DEG_SPOP_SBC_1	335:339	Mutation rewiring degron network	0.1667
p.G345S	SIDM00596	Endometrial Carcinoma	GDSC	VESTS	DEG_SPOP_SBC_1	335:339	Mutation rewiring degron network	0.1667
p.G345S	ACH-001517	Endometrial/Uterine Cancer	CCLE	VESTS	DEG_SPOP_SBC_1	335:339	Mutation rewiring degron network	0.1667
p.G345S	HEC-1	endometrium	COSMIC	VESTS	DEG_SPOP_SBC_1	335:339	Mutation rewiring degron network	0.1667
p.L309I	TCGA-EE-A2GR	SKCM	TCGA	PHTTT	DEG_SPOP_SBC_1	310:314	Mutation rewiring degron network	0.3056
p.L309I	DO37996	SKCM	ICGC	PHTTT	DEG_SPOP_SBC_1	310:314	Mutation rewiring degron network	0.3056
p.D343N	TCGA-GN-A8LK	SKCM	TCGA	VESTS	DEG_SPOP_SBC_1	335:339	Mutation rewiring degron network	0.2222
p.D343N	DO51259	SKCM	ICGC	VESTS	DEG_SPOP_SBC_1	335:339	Mutation rewiring degron network	0.2222
p.K321T	TCGA-HZ-A4BK	PAAD	TCGA	PHTTT	DEG_SPOP_SBC_1	310:314	Mutation substituting flanking lysine	0.25
p.K321T	DO32781	PAAD	ICGC	PHTTT	DEG_SPOP_SBC_1	310:314	Mutation substituting flanking lysine	0.25
p.E317D	TCGA-XF-A9SM	BLCA	TCGA	PHTTT	DEG_SPOP_SBC_1	310:314	Mutation rewiring degron network	0.25
p.E317D	DO223597	BLCA	ICGC	PHTTT	DEG_SPOP_SBC_1	310:314	Mutation rewiring degron network	0.25
p.T312S	DO50499	BOCA	ICGC	PHTTT	DEG_SPOP_SBC_1	310:314	Mutation altering degron motif	0.6005
p.A334V	DO228483	BRCA	ICGC	VESTS	DEG_SPOP_SBC_1	335:339	Mutation rewiring degron network	0.3056
p.A334V	DO52365	LUSC	ICGC	VESTS	DEG_SPOP_SBC_1	335:339	Mutation rewiring degron network	0.3056
p.K322R	DO233918	GACA	ICGC	PHTTT	DEG_SPOP_SBC_1	310:314	Mutation substituting flanking lysine	0.2222
p.A334E	DO228264	LICA	ICGC	VESTS	DEG_SPOP_SBC_1	335:339	Mutation rewiring degron network	0.3056
p.T338A	DO228667	LICA	ICGC	VESTS	DEG_SPOP_SBC_1	335:339	Mutation altering degron motif	0.7139
p.G333A	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	VESTS	DEG_SPOP_SBC_1	335:339	Mutation rewiring degron network	0.2778
p.G333A	ACH-000924	Lung Cancer	CCLE	VESTS	DEG_SPOP_SBC_1	335:339	Mutation rewiring degron network	0.2778
p.G333A	NCI-H2172	lung	COSMIC	VESTS	DEG_SPOP_SBC_1	335:339	Mutation rewiring degron network	0.2778
p.A323T	SIDM00697	Small Cell Lung Carcinoma	GDSC	PHTTT	DEG_SPOP_SBC_1	310:314	Mutation rewiring degron network	0.0833
p.A323T	ACH-000830	Lung Cancer	CCLE	PHTTT	DEG_SPOP_SBC_1	310:314	Mutation rewiring degron network	0.0833
p.A334T	SIDM00120	Prostate Carcinoma	GDSC	VESTS	DEG_SPOP_SBC_1	335:339	Mutation rewiring degron network	0.3056
p.A334T	ACH-000979	Prostate Cancer	CCLE	VESTS	DEG_SPOP_SBC_1	335:339	Mutation rewiring degron network	0.3056
p.A334T	DU-145	prostate	COSMIC	VESTS	DEG_SPOP_SBC_1	335:339	Mutation rewiring degron network	0.3056
p.V335L	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	VESTS	DEG_SPOP_SBC_1	335:339	Mutation altering degron motif	0.6765
p.V335L	ACH-000945	Lung Cancer	CCLE	VESTS	DEG_SPOP_SBC_1	335:339	Mutation altering degron motif	0.6765
p.V335L	NCI-H650	lung	COSMIC	VESTS	DEG_SPOP_SBC_1	335:339	Mutation altering degron motif	0.6765
p.S339F	ACH-000309	Lung Cancer	CCLE	VESTS	DEG_SPOP_SBC_1	335:339	Mutation altering degron motif	0.7982
p.P313L	Hs939-T	skin	COSMIC	PHTTT	DEG_SPOP_SBC_1	310:314	Mutation altering degron motif	0.7582
p.E331K	SW756	cervix	COSMIC	VESTS	DEG_SPOP_SBC_1	335:339	Mutation rewiring degron network	0.2222
p.N337K	RCC-ER	kidney	COSMIC	VESTS	DEG_SPOP_SBC_1	335:339	Mutation altering degron motif	0.6918
p.G303S	HEC-1	endometrium	COSMIC	PHTTT	DEG_SPOP_SBC_1	310:314	Mutation rewiring degron network	0.1389
p.G345R	SF268	central nervous system	COSMIC	VESTS	DEG_SPOP_SBC_1	335:339	Mutation rewiring degron network	0.1667

Kaplan plot for PACSIN1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PACSIN1

UniProt ID: Q9BY11

Entrez ID: 29993

Protein name: Protein kinase C and casein kinase substrate in neurons protein 1 (Syndapin-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PACSIN1 in