DegronMD

Uniprot ID: Q9BY11

Source protein: Protein kinase C and casein kinase substrate in neurons protein 1

Source gene: PACSIN1

Class: DEG_SPOP_SBC_1

Location: 335:339

E3 ligase: SPOP

DEGRON score: 0.6175

ASA_SCORE: 74.34

COIL: 0.6624

CONS_SCORE: 0.3755

DSS_SCORE: 0.5941

HELIX: 0.1374

FCONS_SCORE: 0.9637

RIG_SCORE: 0.6935

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G345S	TCGA-BR-A4IY	STAD	TCGA	VESTS	DEG_SPOP_SBC_1	0.1667
p.G345S	DO228609	LICA	ICGC	VESTS	DEG_SPOP_SBC_1	0.1667
p.G345S	DO38396	STAD	ICGC	VESTS	DEG_SPOP_SBC_1	0.1667
p.G345S	SIDM00596	Endometrial Carcinoma	GDSC	VESTS	DEG_SPOP_SBC_1	0.1667
p.G345S	ACH-001517	Endometrial/Uterine Cancer	CCLE	VESTS	DEG_SPOP_SBC_1	0.1667
p.G345S	HEC-1	endometrium	COSMIC	VESTS	DEG_SPOP_SBC_1	0.1667
p.D343N	TCGA-GN-A8LK	SKCM	TCGA	VESTS	DEG_SPOP_SBC_1	0.2222
p.D343N	DO51259	SKCM	ICGC	VESTS	DEG_SPOP_SBC_1	0.2222
p.A334V	DO228483	BRCA	ICGC	VESTS	DEG_SPOP_SBC_1	0.3056
p.A334V	DO52365	LUSC	ICGC	VESTS	DEG_SPOP_SBC_1	0.3056
p.A334E	DO228264	LICA	ICGC	VESTS	DEG_SPOP_SBC_1	0.3056
p.T338A	DO228667	LICA	ICGC	VESTS	DEG_SPOP_SBC_1	0.7139
p.G333A	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	VESTS	DEG_SPOP_SBC_1	0.2778
p.G333A	ACH-000924	Lung Cancer	CCLE	VESTS	DEG_SPOP_SBC_1	0.2778
p.G333A	NCI-H2172	lung	COSMIC	VESTS	DEG_SPOP_SBC_1	0.2778
p.A334T	SIDM00120	Prostate Carcinoma	GDSC	VESTS	DEG_SPOP_SBC_1	0.3056
p.A334T	ACH-000979	Prostate Cancer	CCLE	VESTS	DEG_SPOP_SBC_1	0.3056
p.A334T	DU-145	prostate	COSMIC	VESTS	DEG_SPOP_SBC_1	0.3056
p.V335L	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	VESTS	DEG_SPOP_SBC_1	0.6765
p.V335L	ACH-000945	Lung Cancer	CCLE	VESTS	DEG_SPOP_SBC_1	0.6765
p.V335L	NCI-H650	lung	COSMIC	VESTS	DEG_SPOP_SBC_1	0.6765
p.S339F	ACH-000309	Lung Cancer	CCLE	VESTS	DEG_SPOP_SBC_1	0.7982
p.E331K	SW756	cervix	COSMIC	VESTS	DEG_SPOP_SBC_1	0.2222
p.N337K	RCC-ER	kidney	COSMIC	VESTS	DEG_SPOP_SBC_1	0.6918
p.G345R	SF268	central_nervous_system	COSMIC	VESTS	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P13611	Versican core protein	DEG_SPOP_SBC_1	2290:2294	VESTS	SPOP	0.6598	More...
P18583	Protein SON	DEG_SPOP_SBC_1	279:283	VESTS	SPOP	0.9537	More...
P41229	Lysine-specific demethylase 5C	DEG_SPOP_SBC_1	283:287	VESTS	SPOP	0.9432	More...
Q04656	Copper-transporting ATPase 1	DEG_SPOP_SBC_1	351:355	VESTS	SPOP	0.6792	More...
Q14693	Phosphatidate phosphatase LPIN1	DEG_SPOP_SBC_1	451:455	VESTS	SPOP	0.9287	More...
Q6UX34	Protein SNORC	DEG_SPOP_SBC_1	49:53	VESTS	SPOP	0.8482	More...
Q8IXF0	Neuronal PAS domain-containing protein 3	DEG_SPOP_SBC_1	245:249	VESTS	SPOP	0.9923	More...
Q8TEP8	Centrosomal protein of 192 kDa	DEG_SPOP_SBC_1	668:672	VESTS	SPOP	0.5574	More...
Q96H15	T-cell immunoglobulin and mucin domain-containing protein 4	DEG_SPOP_SBC_1	240:244	VESTS	SPOP	0.993	More...
Q9BY11	Protein kinase C and casein kinase substrate in neurons protein 1	DEG_SPOP_SBC_1	335:339	VESTS	SPOP	0.6175	More...
Q9NQW6	Anillin	DEG_SPOP_SBC_1	88:92	VESTS	SPOP	0.9904	More...
Q9Y4G2	Pleckstrin homology domain-containing family M member 1	DEG_SPOP_SBC_1	390:394	VESTS	SPOP	0.9903	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons