DegronMD

Uniprot ID: Q14693

Source protein: Phosphatidate phosphatase LPIN1

Source gene: LPIN1

Class: DEG_SPOP_SBC_1

Location: 451:455

E3 ligase: SPOP

DEGRON score: 0.9287

ASA_SCORE: 73.34

COIL: 0.6942

CONS_SCORE: 0.2647

DSS_SCORE: 0.5507

HELIX: 0.0906

FCONS_SCORE: 0.8401

RIG_SCORE: 0.6504

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A460S	TCGA-44-6145	LUAD	TCGA	VESTS	DEG_SPOP_SBC_1	0.1944
p.S453Y	TCGA-94-8491	LUSC	TCGA	VESTS	DEG_SPOP_SBC_1	0.712
p.T463M	TCGA-A5-A0G1	UCEC	TCGA	VESTS	DEG_SPOP_SBC_1	0.1111
p.T463M	TCGA-GM-A5PV	BRCA	TCGA	VESTS	DEG_SPOP_SBC_1	0.1111
p.Q458K	TCGA-HU-A4GT	STAD	TCGA	VESTS	DEG_SPOP_SBC_1	0.25
p.A465T	DO51014	LAML	ICGC	VESTS	DEG_SPOP_SBC_1	0.0556
p.S444I	DO229015	LICA	ICGC	VESTS	DEG_SPOP_SBC_1	0.1389
p.G446D	DO222372	STAD	ICGC	VESTS	DEG_SPOP_SBC_1	0.1944
p.P462R	DO42616	UCEC	ICGC	VESTS	DEG_SPOP_SBC_1	0.1389
p.Q458E	SIDM00994	T-Lymphoblastic Leukemia	GDSC	VESTS	DEG_SPOP_SBC_1	0.25
p.Q458E	SIDM00856	Other Solid Cancers	GDSC	VESTS	DEG_SPOP_SBC_1	0.25
p.P441A	SIDM00617	Hepatocellular Carcinoma	GDSC	VESTS	DEG_SPOP_SBC_1	0.0556
p.P441A	SIDM00781	Colorectal Carcinoma	GDSC	VESTS	DEG_SPOP_SBC_1	0.0556
p.P441A	SIDM00057	Neuroblastoma	GDSC	VESTS	DEG_SPOP_SBC_1	0.0556
p.P441A	SIDM00552	Rhabdomyosarcoma	GDSC	VESTS	DEG_SPOP_SBC_1	0.0556
p.P441A	SIDM00598	Squamous Cell Lung Carcinoma	GDSC	VESTS	DEG_SPOP_SBC_1	0.0556
p.P441A	SIDM00040	Gastric Carcinoma	GDSC	VESTS	DEG_SPOP_SBC_1	0.0556
p.P441A	SIDM00351	Oral Cavity Carcinoma	GDSC	VESTS	DEG_SPOP_SBC_1	0.0556
p.P441A	SIDM00250	Esophageal Squamous Cell Carcinoma	GDSC	VESTS	DEG_SPOP_SBC_1	0.0556
p.P441A	SIDM00502	B-Lymphoblastic Leukemia	GDSC	VESTS	DEG_SPOP_SBC_1	0.0556
p.P441A	SIDM01682	Gastric Carcinoma	GDSC	VESTS	DEG_SPOP_SBC_1	0.0556
p.P441A	SIDM00780	Colorectal Carcinoma	GDSC	VESTS	DEG_SPOP_SBC_1	0.0556
p.P441A	HARA	lung	COSMIC	VESTS	DEG_SPOP_SBC_1	0.0556
p.P441A	TMK-1	stomach	COSMIC	VESTS	DEG_SPOP_SBC_1	0.0556
p.P441A	SNU-C2B	large_intestine	COSMIC	VESTS	DEG_SPOP_SBC_1	0.0556
p.P441A	A4-Fuk	haematopoietic_and_lymphoid_tissue	COSMIC	VESTS	DEG_SPOP_SBC_1	0.0556
p.P441A	TE-4	oesophagus	COSMIC	VESTS	DEG_SPOP_SBC_1	0.0556
p.P441A	JHH-2	liver	COSMIC	VESTS	DEG_SPOP_SBC_1	0.0556
p.P441A	SAS	upper_aerodigestive_tract	COSMIC	VESTS	DEG_SPOP_SBC_1	0.0556
p.P441A	KYM-1	soft_tissue	COSMIC	VESTS	DEG_SPOP_SBC_1	0.0556
p.E447K	SIDM01093	Cervical Carcinoma	GDSC	VESTS	DEG_SPOP_SBC_1	0.2222
p.E447K	SiHa	cervix	COSMIC	VESTS	DEG_SPOP_SBC_1	0.2222
p.A454T	SIDM00980	Gastric Carcinoma	GDSC	VESTS	DEG_SPOP_SBC_1	0.7139
p.A454T	23132-87	stomach	COSMIC	VESTS	DEG_SPOP_SBC_1	0.7139
p.D456G	ASH-3	thyroid	COSMIC	VESTS	DEG_SPOP_SBC_1	0.3056
p.D462G	ASH-3	thyroid	COSMIC	VESTS	DEG_SPOP_SBC_1	0.1389
p.V451M	SK-UT-1	soft_tissue	COSMIC	VESTS	DEG_SPOP_SBC_1	0.7208
p.V457M	SK-UT-1	soft_tissue	COSMIC	VESTS	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P13611	Versican core protein	DEG_SPOP_SBC_1	2290:2294	VESTS	SPOP	0.6598	More...
P18583	Protein SON	DEG_SPOP_SBC_1	279:283	VESTS	SPOP	0.9537	More...
P41229	Lysine-specific demethylase 5C	DEG_SPOP_SBC_1	283:287	VESTS	SPOP	0.9432	More...
Q04656	Copper-transporting ATPase 1	DEG_SPOP_SBC_1	351:355	VESTS	SPOP	0.6792	More...
Q14693	Phosphatidate phosphatase LPIN1	DEG_SPOP_SBC_1	451:455	VESTS	SPOP	0.9287	More...
Q6UX34	Protein SNORC	DEG_SPOP_SBC_1	49:53	VESTS	SPOP	0.8482	More...
Q8IXF0	Neuronal PAS domain-containing protein 3	DEG_SPOP_SBC_1	245:249	VESTS	SPOP	0.9923	More...
Q8TEP8	Centrosomal protein of 192 kDa	DEG_SPOP_SBC_1	668:672	VESTS	SPOP	0.5574	More...
Q96H15	T-cell immunoglobulin and mucin domain-containing protein 4	DEG_SPOP_SBC_1	240:244	VESTS	SPOP	0.993	More...
Q9BY11	Protein kinase C and casein kinase substrate in neurons protein 1	DEG_SPOP_SBC_1	335:339	VESTS	SPOP	0.6175	More...
Q9NQW6	Anillin	DEG_SPOP_SBC_1	88:92	VESTS	SPOP	0.9904	More...
Q9Y4G2	Pleckstrin homology domain-containing family M member 1	DEG_SPOP_SBC_1	390:394	VESTS	SPOP	0.9903	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VESTS

Degron related mutations and impact score

Drug responses associated with LPIN1 mutations

All proteins holding degron of VESTS