DegronMD

Uniprot ID: Q8TEP8

Source protein: Centrosomal protein of 192 kDa

Source gene: CEP192

Class: DEG_SPOP_SBC_1

Location: 668:672

E3 ligase: SPOP

DEGRON score: 0.5574

ASA_SCORE: 82.42

COIL: 0.5896

CONS_SCORE: 0.3536

DSS_SCORE: 0.4708

HELIX: 0.3884

FCONS_SCORE: 0.9281

RIG_SCORE: 0.7334

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T682M	TCGA-AP-A1DR	UCEC	TCGA	VESTS	DEG_SPOP_SBC_1	0.0556
p.T682M	DO43747	UCEC	ICGC	VESTS	DEG_SPOP_SBC_1	0.0556
p.N677S	TCGA-EL-A3GV	THCA	TCGA	VESTS	DEG_SPOP_SBC_1	0.1944
p.N677S	DO39628	THCA	ICGC	VESTS	DEG_SPOP_SBC_1	0.1944
p.Q664K	TCGA-KQ-A41N	BLCA	TCGA	VESTS	DEG_SPOP_SBC_1	0.2222
p.Q664K	DO223588	BLCA	ICGC	VESTS	DEG_SPOP_SBC_1	0.2222
p.T671I	DO223390	CLLE	ICGC	VESTS	DEG_SPOP_SBC_1	0.7078
p.T680M	DO222864	COCA	ICGC	VESTS	DEG_SPOP_SBC_1	0.1111
p.A667S	DO228976	LICA	ICGC	VESTS	DEG_SPOP_SBC_1	0.3056
p.A667S	DO229019	LICA	ICGC	VESTS	DEG_SPOP_SBC_1	0.3056
p.I661V	SIDM00450	Acute Myeloid Leukemia	GDSC	VESTS	DEG_SPOP_SBC_1	0.1389
p.I661V	SIDM00617	Hepatocellular Carcinoma	GDSC	VESTS	DEG_SPOP_SBC_1	0.1389
p.I661V	SIDM01172	Acute Myeloid Leukemia	GDSC	VESTS	DEG_SPOP_SBC_1	0.1389
p.I661V	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	VESTS	DEG_SPOP_SBC_1	0.1389
p.I661V	SIDM00289	B-Lymphoblastic Leukemia	GDSC	VESTS	DEG_SPOP_SBC_1	0.1389
p.I661V	SIDM00279	Gastric Carcinoma	GDSC	VESTS	DEG_SPOP_SBC_1	0.1389
p.I661V	SIDM01435	Hepatocellular Carcinoma	GDSC	VESTS	DEG_SPOP_SBC_1	0.1389
p.S682L	PANC-08-13	pancreas	COSMIC	VESTS	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P13611	Versican core protein	DEG_SPOP_SBC_1	2290:2294	VESTS	SPOP	0.6598	More...
P18583	Protein SON	DEG_SPOP_SBC_1	279:283	VESTS	SPOP	0.9537	More...
P41229	Lysine-specific demethylase 5C	DEG_SPOP_SBC_1	283:287	VESTS	SPOP	0.9432	More...
Q04656	Copper-transporting ATPase 1	DEG_SPOP_SBC_1	351:355	VESTS	SPOP	0.6792	More...
Q14693	Phosphatidate phosphatase LPIN1	DEG_SPOP_SBC_1	451:455	VESTS	SPOP	0.9287	More...
Q6UX34	Protein SNORC	DEG_SPOP_SBC_1	49:53	VESTS	SPOP	0.8482	More...
Q8IXF0	Neuronal PAS domain-containing protein 3	DEG_SPOP_SBC_1	245:249	VESTS	SPOP	0.9923	More...
Q8TEP8	Centrosomal protein of 192 kDa	DEG_SPOP_SBC_1	668:672	VESTS	SPOP	0.5574	More...
Q96H15	T-cell immunoglobulin and mucin domain-containing protein 4	DEG_SPOP_SBC_1	240:244	VESTS	SPOP	0.993	More...
Q9BY11	Protein kinase C and casein kinase substrate in neurons protein 1	DEG_SPOP_SBC_1	335:339	VESTS	SPOP	0.6175	More...
Q9NQW6	Anillin	DEG_SPOP_SBC_1	88:92	VESTS	SPOP	0.9904	More...
Q9Y4G2	Pleckstrin homology domain-containing family M member 1	DEG_SPOP_SBC_1	390:394	VESTS	SPOP	0.9903	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons