DegronMD

Uniprot ID: P41229

Source protein: Lysine-specific demethylase 5C

Source gene: KDM5C

Class: DEG_SPOP_SBC_1

Location: 283:287

E3 ligase: SPOP

DEGRON score: 0.9432

ASA_SCORE: 82.54

COIL: 0.8152

CONS_SCORE: 0.2258

DSS_SCORE: 0.5433

HELIX: 0.049

FCONS_SCORE: 0.978

RIG_SCORE: 0.7043

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S287L	TCGA-74-6581	GBM	TCGA	VESTS	DEG_SPOP_SBC_1	0.8778
p.S287L	DO11531	GBM	ICGC	VESTS	DEG_SPOP_SBC_1	0.8778
p.T286A	TCGA-HE-A5NH	KIRP	TCGA	VESTS	DEG_SPOP_SBC_1	0.7139
p.T286A	DO44485	KIRP	ICGC	VESTS	DEG_SPOP_SBC_1	0.7139
p.D280V	DO222755	COCA	ICGC	VESTS	DEG_SPOP_SBC_1	0.25
p.D293N	DO43891	UCEC	ICGC	VESTS	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P13611	Versican core protein	DEG_SPOP_SBC_1	2290:2294	VESTS	SPOP	0.6598	More...
P18583	Protein SON	DEG_SPOP_SBC_1	279:283	VESTS	SPOP	0.9537	More...
P41229	Lysine-specific demethylase 5C	DEG_SPOP_SBC_1	283:287	VESTS	SPOP	0.9432	More...
Q04656	Copper-transporting ATPase 1	DEG_SPOP_SBC_1	351:355	VESTS	SPOP	0.6792	More...
Q14693	Phosphatidate phosphatase LPIN1	DEG_SPOP_SBC_1	451:455	VESTS	SPOP	0.9287	More...
Q6UX34	Protein SNORC	DEG_SPOP_SBC_1	49:53	VESTS	SPOP	0.8482	More...
Q8IXF0	Neuronal PAS domain-containing protein 3	DEG_SPOP_SBC_1	245:249	VESTS	SPOP	0.9923	More...
Q8TEP8	Centrosomal protein of 192 kDa	DEG_SPOP_SBC_1	668:672	VESTS	SPOP	0.5574	More...
Q96H15	T-cell immunoglobulin and mucin domain-containing protein 4	DEG_SPOP_SBC_1	240:244	VESTS	SPOP	0.993	More...
Q9BY11	Protein kinase C and casein kinase substrate in neurons protein 1	DEG_SPOP_SBC_1	335:339	VESTS	SPOP	0.6175	More...
Q9NQW6	Anillin	DEG_SPOP_SBC_1	88:92	VESTS	SPOP	0.9904	More...
Q9Y4G2	Pleckstrin homology domain-containing family M member 1	DEG_SPOP_SBC_1	390:394	VESTS	SPOP	0.9903	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons