DegronMD

Uniprot ID: Q8IXF0

Source protein: Neuronal PAS domain-containing protein 3

Source gene: NPAS3

Class: DEG_SPOP_SBC_1

Location: 245:249

E3 ligase: SPOP

DEGRON score: 0.9923

ASA_SCORE: 79.54

COIL: 0.8682

CONS_SCORE: 0.339

DSS_SCORE: 0.7188

HELIX: 0.074

FCONS_SCORE: 1.1234

RIG_SCORE: 0.6187

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D256H	TCGA-55-7995	LUAD	TCGA	VESTS	DEG_SPOP_SBC_1	0.1389
p.Q238K	TCGA-56-8083	LUSC	TCGA	VESTS	DEG_SPOP_SBC_1	0.1389
p.S249C	TCGA-66-2768	LUSC	TCGA	VESTS	DEG_SPOP_SBC_1	0.7541
p.S249A	DO7801	COAD	ICGC	VESTS	DEG_SPOP_SBC_1	0.7588
p.R242H	DO227976	COCA	ICGC	VESTS	DEG_SPOP_SBC_1	0.25
p.R242C	DO233642	GACA	ICGC	VESTS	DEG_SPOP_SBC_1	0.25
p.Q254H	DO229045	LICA	ICGC	VESTS	DEG_SPOP_SBC_1	0.1944
p.T240N	DO231587	LINC	ICGC	VESTS	DEG_SPOP_SBC_1	0.1944
p.I246S	DO26814	LUSC	ICGC	VESTS	DEG_SPOP_SBC_1	0.7341
p.R259W	DO220122	SARC	ICGC	VESTS	DEG_SPOP_SBC_1	0.0556
p.R259W	DO43755	UCEC	ICGC	VESTS	DEG_SPOP_SBC_1	0.0556
p.T238N	DO43306	UCEC	ICGC	VESTS	DEG_SPOP_SBC_1	0.1389
p.S247P	SIDM00434	Plasma Cell Myeloma	GDSC	VESTS	DEG_SPOP_SBC_1	0.6752
p.S247P	MOLP-8	haematopoietic_and_lymphoid_tissue	COSMIC	VESTS	DEG_SPOP_SBC_1	0.6752
p.S252P	ACH-000745	Myeloma	CCLE	VESTS	DEG_SPOP_SBC_1	0.25
p.S252P	ACH-001673	Bile Duct Cancer	CCLE	VESTS	DEG_SPOP_SBC_1	0.25
p.S252P	MOLP-8	haematopoietic_and_lymphoid_tissue	COSMIC	VESTS	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P13611	Versican core protein	DEG_SPOP_SBC_1	2290:2294	VESTS	SPOP	0.6598	More...
P18583	Protein SON	DEG_SPOP_SBC_1	279:283	VESTS	SPOP	0.9537	More...
P41229	Lysine-specific demethylase 5C	DEG_SPOP_SBC_1	283:287	VESTS	SPOP	0.9432	More...
Q04656	Copper-transporting ATPase 1	DEG_SPOP_SBC_1	351:355	VESTS	SPOP	0.6792	More...
Q14693	Phosphatidate phosphatase LPIN1	DEG_SPOP_SBC_1	451:455	VESTS	SPOP	0.9287	More...
Q6UX34	Protein SNORC	DEG_SPOP_SBC_1	49:53	VESTS	SPOP	0.8482	More...
Q8IXF0	Neuronal PAS domain-containing protein 3	DEG_SPOP_SBC_1	245:249	VESTS	SPOP	0.9923	More...
Q8TEP8	Centrosomal protein of 192 kDa	DEG_SPOP_SBC_1	668:672	VESTS	SPOP	0.5574	More...
Q96H15	T-cell immunoglobulin and mucin domain-containing protein 4	DEG_SPOP_SBC_1	240:244	VESTS	SPOP	0.993	More...
Q9BY11	Protein kinase C and casein kinase substrate in neurons protein 1	DEG_SPOP_SBC_1	335:339	VESTS	SPOP	0.6175	More...
Q9NQW6	Anillin	DEG_SPOP_SBC_1	88:92	VESTS	SPOP	0.9904	More...
Q9Y4G2	Pleckstrin homology domain-containing family M member 1	DEG_SPOP_SBC_1	390:394	VESTS	SPOP	0.9903	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons