DegronMD

Uniprot ID: Q04656

Source protein: Copper-transporting ATPase 1

Source gene: ATP7A

Class: DEG_SPOP_SBC_1

Location: 351:355

E3 ligase: SPOP

DEGRON score: 0.6792

ASA_SCORE: 81.46

COIL: 0.776

CONS_SCORE: 0.2574

DSS_SCORE: 0.4662

HELIX: 0.1546

FCONS_SCORE: 0.9582

RIG_SCORE: 0.6457

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S353R	TCGA-AU-6004	COAD	TCGA	VESTS	DEG_SPOP_SBC_1	0.8538
p.S353R	DO7780	COAD	ICGC	VESTS	DEG_SPOP_SBC_1	0.8538
p.S349C	TCGA-EO-A22X	UCEC	TCGA	VESTS	DEG_SPOP_SBC_1	0.7222
p.S349C	DO43907	UCEC	ICGC	VESTS	DEG_SPOP_SBC_1	0.7222
p.L363I	TCGA-L4-A4E5	LUAD	TCGA	VESTS	DEG_SPOP_SBC_1	0.1111
p.L363I	DO24320	LUAD	ICGC	VESTS	DEG_SPOP_SBC_1	0.1111
p.E353D	DO50820	LIRI	ICGC	VESTS	DEG_SPOP_SBC_1	0.6758
p.F364V	DO43891	UCEC	ICGC	VESTS	DEG_SPOP_SBC_1	0.0833
p.Q364H	SIDM00728	Non-Small Cell Lung Carcinoma	GDSC	VESTS	DEG_SPOP_SBC_1	0.0833
p.Q364H	NCI-H2291	lung	COSMIC	VESTS	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P13611	Versican core protein	DEG_SPOP_SBC_1	2290:2294	VESTS	SPOP	0.6598	More...
P18583	Protein SON	DEG_SPOP_SBC_1	279:283	VESTS	SPOP	0.9537	More...
P41229	Lysine-specific demethylase 5C	DEG_SPOP_SBC_1	283:287	VESTS	SPOP	0.9432	More...
Q04656	Copper-transporting ATPase 1	DEG_SPOP_SBC_1	351:355	VESTS	SPOP	0.6792	More...
Q14693	Phosphatidate phosphatase LPIN1	DEG_SPOP_SBC_1	451:455	VESTS	SPOP	0.9287	More...
Q6UX34	Protein SNORC	DEG_SPOP_SBC_1	49:53	VESTS	SPOP	0.8482	More...
Q8IXF0	Neuronal PAS domain-containing protein 3	DEG_SPOP_SBC_1	245:249	VESTS	SPOP	0.9923	More...
Q8TEP8	Centrosomal protein of 192 kDa	DEG_SPOP_SBC_1	668:672	VESTS	SPOP	0.5574	More...
Q96H15	T-cell immunoglobulin and mucin domain-containing protein 4	DEG_SPOP_SBC_1	240:244	VESTS	SPOP	0.993	More...
Q9BY11	Protein kinase C and casein kinase substrate in neurons protein 1	DEG_SPOP_SBC_1	335:339	VESTS	SPOP	0.6175	More...
Q9NQW6	Anillin	DEG_SPOP_SBC_1	88:92	VESTS	SPOP	0.9904	More...
Q9Y4G2	Pleckstrin homology domain-containing family M member 1	DEG_SPOP_SBC_1	390:394	VESTS	SPOP	0.9903	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons