DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
VESTS
Uniprot ID:
Q6UX34
Source protein:
Protein SNORC
Source gene:
SNORC
Class:
DEG_SPOP_SBC_1
Location:
49:53
E3 ligase:
SPOP
DEGRON score:
0.8482
ASA_SCORE:
65.38
COIL:
0.7978
CONS_SCORE:
0.6263
DSS_SCORE:
0.8468
HELIX:
0.0758
FCONS_SCORE:
0.8724
RIG_SCORE:
0.5382
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with SNORC mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VESTS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P13611
Versican core protein
DEG_SPOP_SBC_1
2290:2294
VESTS
SPOP
0.6598
More...
P18583
Protein SON
DEG_SPOP_SBC_1
279:283
VESTS
SPOP
0.9537
More...
P41229
Lysine-specific demethylase 5C
DEG_SPOP_SBC_1
283:287
VESTS
SPOP
0.9432
More...
Q04656
Copper-transporting ATPase 1
DEG_SPOP_SBC_1
351:355
VESTS
SPOP
0.6792
More...
Q14693
Phosphatidate phosphatase LPIN1
DEG_SPOP_SBC_1
451:455
VESTS
SPOP
0.9287
More...
Q6UX34
Protein SNORC
DEG_SPOP_SBC_1
49:53
VESTS
SPOP
0.8482
More...
Q8IXF0
Neuronal PAS domain-containing protein 3
DEG_SPOP_SBC_1
245:249
VESTS
SPOP
0.9923
More...
Q8TEP8
Centrosomal protein of 192 kDa
DEG_SPOP_SBC_1
668:672
VESTS
SPOP
0.5574
More...
Q96H15
T-cell immunoglobulin and mucin domain-containing protein 4
DEG_SPOP_SBC_1
240:244
VESTS
SPOP
0.993
More...
Q9BY11
Protein kinase C and casein kinase substrate in neurons protein 1
DEG_SPOP_SBC_1
335:339
VESTS
SPOP
0.6175
More...
Q9NQW6
Anillin
DEG_SPOP_SBC_1
88:92
VESTS
SPOP
0.9904
More...
Q9Y4G2
Pleckstrin homology domain-containing family M member 1
DEG_SPOP_SBC_1
390:394
VESTS
SPOP
0.9903
More...