DegronMD

Uniprot ID: P13611

Source protein: Versican core protein

Source gene: VCAN

Class: DEG_SPOP_SBC_1

Location: 2290:2294

E3 ligase: SPOP

DEGRON score: 0.6598

ASA_SCORE: 86.92

COIL: 0.7354

CONS_SCORE: 0.4536

DSS_SCORE: 0.5338

HELIX: 0.0336

FCONS_SCORE: 1.0277

RIG_SCORE: 0.6985

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P2285T	TCGA-AA-A00N	COAD	TCGA	VESTS	DEG_SPOP_SBC_1	0.1944
p.P2285T	DO9876	COAD	ICGC	VESTS	DEG_SPOP_SBC_1	0.1944
p.M2304I	TCGA-BF-A1PU	SKCM	TCGA	VESTS	DEG_SPOP_SBC_1	0.0556
p.M2304I	DO50278	SKCM	ICGC	VESTS	DEG_SPOP_SBC_1	0.0556
p.R2303K	TCGA-XF-A9T8	BLCA	TCGA	VESTS	DEG_SPOP_SBC_1	0.0833
p.R2303K	DO51927	BLCA	ICGC	VESTS	DEG_SPOP_SBC_1	0.0833
p.F2301Y	DO230334	COCA	ICGC	VESTS	DEG_SPOP_SBC_1	0.1389
p.F2301Y	DO229010	COCA	ICGC	VESTS	DEG_SPOP_SBC_1	0.1389
p.F2301Y	DO229013	COCA	ICGC	VESTS	DEG_SPOP_SBC_1	0.1389
p.F2301Y	DO229016	COCA	ICGC	VESTS	DEG_SPOP_SBC_1	0.1389
p.F2301Y	DO229346	LAML	ICGC	VESTS	DEG_SPOP_SBC_1	0.1389
p.F2301Y	DO229480	LAML	ICGC	VESTS	DEG_SPOP_SBC_1	0.1389
p.F2301Y	DO228941	LICA	ICGC	VESTS	DEG_SPOP_SBC_1	0.1389
p.F2301Y	DO228947	LICA	ICGC	VESTS	DEG_SPOP_SBC_1	0.1389
p.F2301Y	DO229047	LICA	ICGC	VESTS	DEG_SPOP_SBC_1	0.1389
p.F2301Y	DO230990	LUSC	ICGC	VESTS	DEG_SPOP_SBC_1	0.1389
p.V2292I	HCC1395	breast	COSMIC	VESTS	DEG_SPOP_SBC_1	0.7076
p.P2293S	SW684	soft_tissue	COSMIC	VESTS	DEG_SPOP_SBC_1	0.6752
p.T2301M	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	VESTS	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P13611	Versican core protein	DEG_SPOP_SBC_1	2290:2294	VESTS	SPOP	0.6598	More...
P18583	Protein SON	DEG_SPOP_SBC_1	279:283	VESTS	SPOP	0.9537	More...
P41229	Lysine-specific demethylase 5C	DEG_SPOP_SBC_1	283:287	VESTS	SPOP	0.9432	More...
Q04656	Copper-transporting ATPase 1	DEG_SPOP_SBC_1	351:355	VESTS	SPOP	0.6792	More...
Q14693	Phosphatidate phosphatase LPIN1	DEG_SPOP_SBC_1	451:455	VESTS	SPOP	0.9287	More...
Q6UX34	Protein SNORC	DEG_SPOP_SBC_1	49:53	VESTS	SPOP	0.8482	More...
Q8IXF0	Neuronal PAS domain-containing protein 3	DEG_SPOP_SBC_1	245:249	VESTS	SPOP	0.9923	More...
Q8TEP8	Centrosomal protein of 192 kDa	DEG_SPOP_SBC_1	668:672	VESTS	SPOP	0.5574	More...
Q96H15	T-cell immunoglobulin and mucin domain-containing protein 4	DEG_SPOP_SBC_1	240:244	VESTS	SPOP	0.993	More...
Q9BY11	Protein kinase C and casein kinase substrate in neurons protein 1	DEG_SPOP_SBC_1	335:339	VESTS	SPOP	0.6175	More...
Q9NQW6	Anillin	DEG_SPOP_SBC_1	88:92	VESTS	SPOP	0.9904	More...
Q9Y4G2	Pleckstrin homology domain-containing family M member 1	DEG_SPOP_SBC_1	390:394	VESTS	SPOP	0.9903	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons