DegronMD - P41229(KDM5C)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S287L	TCGA-74-6581	GBM	TCGA	VESTS	DEG_SPOP_SBC_1	283:287	Mutation altering degron motif	0.8778
p.S287L	DO11531	GBM	ICGC	VESTS	DEG_SPOP_SBC_1	283:287	Mutation altering degron motif	0.8778
p.R1314W	TCGA-BG-A222	UCEC	TCGA	PPNY	ITCH	1324:1327	Mutation rewiring degron network	0.0556
p.R1314W	DO42977	UCEC	ICGC	PPNY	ITCH	1324:1327	Mutation rewiring degron network	0.0556
p.P1331T	TCGA-GN-A265	SKCM	TCGA	PPNY	ITCH	1324:1327	Mutation rewiring degron network	0.2222
p.P1331T	DO37491	SKCM	ICGC	PPNY	ITCH	1324:1327	Mutation rewiring degron network	0.2222
p.T286A	TCGA-HE-A5NH	KIRP	TCGA	VESTS	DEG_SPOP_SBC_1	283:287	Mutation altering degron motif	0.7139
p.T286A	DO44485	KIRP	ICGC	VESTS	DEG_SPOP_SBC_1	283:287	Mutation altering degron motif	0.7139
p.S1178L	TCGA-LN-A9FO	ESCA	TCGA	ASSTT	DEG_SPOP_SBC_1	1181:1185	Mutation rewiring degron network	0.25
p.D280V	DO222755	COCA	ICGC	VESTS	DEG_SPOP_SBC_1	283:287	Mutation rewiring degron network	0.25
p.E1322Q	DO223032	ESCA	ICGC	PPNY	ITCH	1324:1327	Mutation rewiring degron network	0.2778
p.P1319A	DO233630	GACA	ICGC	PPNY	ITCH	1324:1327	Mutation rewiring degron network	0.1944
p.P1319T	DO228945	LICA	ICGC	PPNY	ITCH	1324:1327	Mutation rewiring degron network	0.1944
p.P1328T	DO229031	LICA	ICGC	PPNY	ITCH	1324:1327	Mutation rewiring degron network	0.3056
p.E1318D	DO220877	MELA	ICGC	PPNY	ITCH	1324:1327	Mutation rewiring degron network	0.1667
p.D293N	DO43891	UCEC	ICGC	VESTS	DEG_SPOP_SBC_1	283:287	Mutation rewiring degron network	0.1667
p.C1188S	ACH-001061	Colon/Colorectal Cancer	CCLE	ASSTT	DEG_SPOP_SBC_1	1181:1185	Mutation rewiring degron network	0.25
p.Q1316K	ACH-002222	Leukemia	CCLE	PPNY	ITCH	1324:1327	Mutation rewiring degron network	0.1111
p.P1182L	SW48	large intestine	COSMIC	ASSTT	DEG_SPOP_SBC_1	1181:1185	Mutation altering degron motif	0.7582

Kaplan plot for KDM5C in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KDM5C

UniProt ID: P41229

Entrez ID: 8242

Protein name: Lysine-specific demethylase 5C (EC 1.14.11.67) (Histone demethylase JARID1C) (Jumonji/ARID domain-containing protein 1C) (Protein SmcX) (Protein Xe169) ([histone H3]-trimethyl-L-lysine(4) demethylase 5C)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KDM5C in