DegronMD

Uniprot ID: Q9NQW6

Source protein: Anillin

Source gene: ANLN

Class: DEG_SPOP_SBC_1

Location: 88:92

E3 ligase: SPOP

DEGRON score: 0.9904

ASA_SCORE: 102.94

COIL: 0.9288

CONS_SCORE: 0.3816

DSS_SCORE: 0.5946

HELIX: 0.0448

FCONS_SCORE: 0.9364

RIG_SCORE: 0.6366

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V79I	TCGA-91-6848	LUAD	TCGA	VESTS	DEG_SPOP_SBC_1	0.0833
p.V79I	TCGA-BS-A0UF	UCEC	TCGA	VESTS	DEG_SPOP_SBC_1	0.0833
p.V79I	DO23846	LUAD	ICGC	VESTS	DEG_SPOP_SBC_1	0.0833
p.V79I	DO41488	UCEC	ICGC	VESTS	DEG_SPOP_SBC_1	0.0833
p.E78D	TCGA-EO-A3B0	UCEC	TCGA	VESTS	DEG_SPOP_SBC_1	0.0556
p.E78D	DO219773	UCEC	ICGC	VESTS	DEG_SPOP_SBC_1	0.0556
p.P87L	TCGA-GC-A3YS	BLCA	TCGA	VESTS	DEG_SPOP_SBC_1	0.3056
p.P87L	DO850	BLCA	ICGC	VESTS	DEG_SPOP_SBC_1	0.3056
p.E89D	TCGA-NJ-A4YF	LUAD	TCGA	VESTS	DEG_SPOP_SBC_1	0.5647
p.E89D	DO218940	LUAD	ICGC	VESTS	DEG_SPOP_SBC_1	0.5647
p.K94Q	DO48457	BLCA	ICGC	VESTS	DEG_SPOP_SBC_1	0.2778
p.K85I	DO228187	LICA	ICGC	VESTS	DEG_SPOP_SBC_1	0.6944
p.A93V	DO231939	LICA	ICGC	VESTS	DEG_SPOP_SBC_1	0.3056
p.L82F	DO229024	LICA	ICGC	VESTS	DEG_SPOP_SBC_1	0.1667
p.C96Y	SIDM00901	Endometrial Carcinoma	GDSC	VESTS	DEG_SPOP_SBC_1	0.2222
p.C96Y	ACH-000940	Endometrial/Uterine Cancer	CCLE	VESTS	DEG_SPOP_SBC_1	0.2222
p.C96Y	AN3-CA	endometrium	COSMIC	VESTS	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P13611	Versican core protein	DEG_SPOP_SBC_1	2290:2294	VESTS	SPOP	0.6598	More...
P18583	Protein SON	DEG_SPOP_SBC_1	279:283	VESTS	SPOP	0.9537	More...
P41229	Lysine-specific demethylase 5C	DEG_SPOP_SBC_1	283:287	VESTS	SPOP	0.9432	More...
Q04656	Copper-transporting ATPase 1	DEG_SPOP_SBC_1	351:355	VESTS	SPOP	0.6792	More...
Q14693	Phosphatidate phosphatase LPIN1	DEG_SPOP_SBC_1	451:455	VESTS	SPOP	0.9287	More...
Q6UX34	Protein SNORC	DEG_SPOP_SBC_1	49:53	VESTS	SPOP	0.8482	More...
Q8IXF0	Neuronal PAS domain-containing protein 3	DEG_SPOP_SBC_1	245:249	VESTS	SPOP	0.9923	More...
Q8TEP8	Centrosomal protein of 192 kDa	DEG_SPOP_SBC_1	668:672	VESTS	SPOP	0.5574	More...
Q96H15	T-cell immunoglobulin and mucin domain-containing protein 4	DEG_SPOP_SBC_1	240:244	VESTS	SPOP	0.993	More...
Q9BY11	Protein kinase C and casein kinase substrate in neurons protein 1	DEG_SPOP_SBC_1	335:339	VESTS	SPOP	0.6175	More...
Q9NQW6	Anillin	DEG_SPOP_SBC_1	88:92	VESTS	SPOP	0.9904	More...
Q9Y4G2	Pleckstrin homology domain-containing family M member 1	DEG_SPOP_SBC_1	390:394	VESTS	SPOP	0.9903	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons