DegronMD

Uniprot ID: Q96H15

Source protein: T-cell immunoglobulin and mucin domain-containing protein 4

Source gene: TIMD4

Class: DEG_SPOP_SBC_1

Location: 240:244

E3 ligase: SPOP

DEGRON score: 0.993

ASA_SCORE: 76.06

COIL: 0.6992

CONS_SCORE: 0.345

DSS_SCORE: 0.399

HELIX: 0.0234

FCONS_SCORE: 0.8804

RIG_SCORE: 0.7218

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S244Y	TCGA-AJ-A3EK	UCEC	TCGA	VESTS	DEG_SPOP_SBC_1	0.712
p.S244Y	DO41584	UCEC	ICGC	VESTS	DEG_SPOP_SBC_1	0.712
p.V240A	DO229010	COCA	ICGC	VESTS	DEG_SPOP_SBC_1	0.5825
p.V240A	DO229013	COCA	ICGC	VESTS	DEG_SPOP_SBC_1	0.5825
p.V240A	DO229016	COCA	ICGC	VESTS	DEG_SPOP_SBC_1	0.5825
p.V240A	DO229003	COCA	ICGC	VESTS	DEG_SPOP_SBC_1	0.5825
p.V240A	DO229005	COCA	ICGC	VESTS	DEG_SPOP_SBC_1	0.5825
p.S239I	TCGA-92-8065	LUSC	TCGA	VESTS	DEG_SPOP_SBC_1	0.3056
p.S239I	DO27074	LUSC	ICGC	VESTS	DEG_SPOP_SBC_1	0.3056
p.A245T	TCGA-DM-A1D6	COAD	TCGA	VESTS	DEG_SPOP_SBC_1	0.3056
p.A245T	DO10686	COAD	ICGC	VESTS	DEG_SPOP_SBC_1	0.3056
p.D246E	ACH-000700	Lung Cancer	CCLE	VESTS	DEG_SPOP_SBC_1	0.2778
p.S236F	SIDM00444	Esophageal Carcinoma	GDSC	VESTS	DEG_SPOP_SBC_1	0.2222
p.S236F	OACM5-1	oesophagus	COSMIC	VESTS	DEG_SPOP_SBC_1	0.2222
p.L249R	TCGA-44-2659	LUAD	TCGA	VESTS	DEG_SPOP_SBC_1	0.1944
p.L249R	DO23744	LUAD	ICGC	VESTS	DEG_SPOP_SBC_1	0.1944
p.D235N	TCGA-W3-A825	SKCM	TCGA	VESTS	DEG_SPOP_SBC_1	0.1944
p.D235N	DO51272	SKCM	ICGC	VESTS	DEG_SPOP_SBC_1	0.1944
p.L250P	DO232832	NACA	ICGC	VESTS	DEG_SPOP_SBC_1	0.1667
p.S252F	TCGA-B5-A3FC	UCEC	TCGA	VESTS	DEG_SPOP_SBC_1	0.1111
p.S252F	DO41871	UCEC	ICGC	VESTS	DEG_SPOP_SBC_1	0.1111
p.L232F	TCGA-EE-A2MS	SKCM	TCGA	VESTS	DEG_SPOP_SBC_1	0.1111
p.L232F	DO37567	SKCM	ICGC	VESTS	DEG_SPOP_SBC_1	0.1111
p.T230A	TCGA-AX-A06F	UCEC	TCGA	VESTS	DEG_SPOP_SBC_1	0.0556
p.T230A	DO41752	UCEC	ICGC	VESTS	DEG_SPOP_SBC_1	0.0556

Showing 1 to 25 of 25 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NQW6	Anillin	DEG_SPOP_SBC_1	88:92	VESTS	SPOP	0.9904	More...
Q8TEP8	Centrosomal protein of 192 kDa	DEG_SPOP_SBC_1	668:672	VESTS	SPOP	0.5574	More...
Q04656	Copper-transporting ATPase 1	DEG_SPOP_SBC_1	351:355	VESTS	SPOP	0.6792	More...
P41229	Lysine-specific demethylase 5C	DEG_SPOP_SBC_1	283:287	VESTS	SPOP	0.9432	More...
Q8IXF0	Neuronal PAS domain-containing protein 3	DEG_SPOP_SBC_1	245:249	VESTS	SPOP	0.9923	More...
Q14693	Phosphatidate phosphatase LPIN1	DEG_SPOP_SBC_1	451:455	VESTS	SPOP	0.9287	More...
Q9Y4G2	Pleckstrin homology domain-containing family M member 1	DEG_SPOP_SBC_1	390:394	VESTS	SPOP	0.9903	More...
Q9BY11	Protein kinase C and casein kinase substrate in neurons protein 1	DEG_SPOP_SBC_1	335:339	VESTS	SPOP	0.6175	More...
Q6UX34	Protein SNORC	DEG_SPOP_SBC_1	49:53	VESTS	SPOP	0.8482	More...
P18583	Protein SON	DEG_SPOP_SBC_1	279:283	VESTS	SPOP	0.9537	More...
Q96H15	T-cell immunoglobulin and mucin domain-containing protein 4	DEG_SPOP_SBC_1	240:244	VESTS	SPOP	0.993	More...
P13611	Versican core protein	DEG_SPOP_SBC_1	2290:2294	VESTS	SPOP	0.6598	More...

Showing 1 to 12 of 12 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons